ARTN — 37 ClinVar variants
All ClinVar germline ARTN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
37 Uncertain significance
Full ARTN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ARTN p.Ala157Ser Uncertain significance Single submitter
- ARTN p.Ala59Gly Uncertain significance Single submitter
- ARTN p.Ala94Pro Uncertain significance Single submitter
- ARTN p.Arg116Gly Uncertain significance Single submitter
- ARTN p.Arg158Cys Uncertain significance Single submitter
- ARTN p.Asp162Gly Uncertain significance Single submitter
- ARTN p.Cys154Tyr Uncertain significance Single submitter
- ARTN p.Cys187Tyr Uncertain significance Single submitter
- ARTN p.Gln84Pro Uncertain significance Single submitter
- ARTN p.Glu143Asp Uncertain significance Single submitter
- ARTN p.Gly110Ala Uncertain significance Single submitter
- ARTN p.Gly110Ser Uncertain significance Single submitter
- ARTN p.Gly63Val Uncertain significance Single submitter
- ARTN p.Leu5Val Uncertain significance Single submitter
- ARTN p.Pro85Arg Uncertain significance Single submitter
- ARTN p.Ser113Gly Uncertain significance Single submitter
- ARTN p.Thr10Lys Uncertain significance Single submitter
- ARTN p.Thr10Met Uncertain significance Single submitter
- ARTN p.Val201Asp Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- ARTN p.Ala115Val Uncertain significance Single submitter
- ARTN p.Ala89Thr Uncertain significance Single submitter
- ARTN p.Arg140His Uncertain significance Single submitter
- ARTN p.Arg206Lys Uncertain significance Single submitter
- ARTN p.Arg46His Uncertain significance Single submitter
- ARTN p.Arg72His Uncertain significance Single submitter
- ARTN p.Leu174Pro Uncertain significance Single submitter
- ARTN p.Leu219Gln Uncertain significance Single submitter
- ARTN p.Pro100Thr Uncertain significance Single submitter
- ARTN p.Pro176Gln Uncertain significance Single submitter
- ARTN p.Pro55Leu Uncertain significance Single submitter
- ARTN p.Pro61Leu Uncertain significance Single submitter
- ARTN p.Pro66Gln Uncertain significance Single submitter
- ARTN p.Pro85Leu Uncertain significance Single submitter
- ARTN p.Pro90Ser Uncertain significance Single submitter
- ARTN p.Pro95Ser Uncertain significance Single submitter
- ARTN p.Ser35Asn Uncertain significance Single submitter
- ARTN p.Val196Ile Uncertain significance Single submitter
All ARTN variants
Uncertain significance 37
- p.Ala115Val Single submitter ⚠
- p.Ala157Ser Single submitter ⚠
- p.Ala59Gly Single submitter ⚠
- p.Ala89Thr Single submitter ⚠
- p.Ala94Pro Single submitter ⚠
- p.Arg116Gly Single submitter ⚠
- p.Arg140His Single submitter ⚠
- p.Arg158Cys Single submitter ⚠
- p.Arg206Lys Single submitter ⚠
- p.Arg46His Single submitter ⚠
- p.Arg72His Single submitter ⚠
- p.Asp162Gly Single submitter ⚠
- p.Cys154Tyr Single submitter ⚠
- p.Cys187Tyr Single submitter ⚠
- p.Gln84Pro Single submitter ⚠
- p.Glu143Asp Single submitter ⚠
- p.Gly110Ala Single submitter ⚠
- p.Gly110Ser Single submitter ⚠
- p.Gly63Val Single submitter ⚠
- p.Leu174Pro Single submitter ⚠
- p.Leu219Gln Single submitter ⚠
- p.Leu5Val Single submitter ⚠
- p.Pro100Thr Single submitter ⚠
- p.Pro176Gln Single submitter ⚠
- p.Pro55Leu Single submitter ⚠
- p.Pro61Leu Single submitter ⚠
- p.Pro66Gln Single submitter ⚠
- p.Pro85Arg Single submitter ⚠
- p.Pro85Leu Single submitter ⚠
- p.Pro90Ser Single submitter ⚠
- p.Pro95Ser Single submitter ⚠
- p.Ser113Gly Single submitter ⚠
- p.Ser35Asn Single submitter ⚠
- p.Thr10Lys Single submitter ⚠
- p.Thr10Met Single submitter ⚠
- p.Val196Ile Single submitter ⚠
- p.Val201Asp Single submitter ⚠