ASB11 — 47 ClinVar variants
All ClinVar germline ASB11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
2 Benign · 4 Likely benign · 41 Uncertain significance
Full ASB11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ASB11 p.Arg256His Uncertain significance Multiple submitters
- ASB11 p.Ala259Gly Uncertain significance Single submitter
- ASB11 p.Arg292Leu Uncertain significance Single submitter
- ASB11 p.Arg77Leu Uncertain significance Single submitter
- ASB11 p.Asp3Gly Uncertain significance Single submitter
- ASB11 p.Cys146Arg Uncertain significance Single submitter
- ASB11 p.Cys291Arg Uncertain significance Single submitter
- ASB11 p.Gly197Arg Uncertain significance Single submitter
- ASB11 p.Pro5Leu Uncertain significance Single submitter
- ASB11 p.Thr20Met Uncertain significance Single submitter
- ASB11 p.Thr230Ser Uncertain significance Single submitter
- ASB11 p.Val41Ile Uncertain significance Single submitter
- ASB11 p.Val99Leu Uncertain significance Single submitter
Predictors split 29
The independent predictors disagree with each other — read with care.
- ASB11 p.Arg208Trp Benign Multiple submitters
- ASB11 p.Asp249Asn Benign Multiple submitters
- ASB11 p.Ala114Gly Uncertain significance Single submitter
- ASB11 p.Ala145Thr Uncertain significance Single submitter
- ASB11 p.Ala268Val Uncertain significance Single submitter
- ASB11 p.Arg281Cys Uncertain significance Single submitter
- ASB11 p.Arg292Cys Uncertain significance Single submitter
- ASB11 p.Arg296Trp Uncertain significance Single submitter
- ASB11 p.Asn148Ile Uncertain significance Single submitter
- ASB11 p.Asn258Thr Uncertain significance Single submitter
- ASB11 p.Gln158Leu Uncertain significance Single submitter
- ASB11 p.Glu177Gln Uncertain significance Single submitter
- ASB11 p.Glu177Lys Uncertain significance Single submitter
- ASB11 p.Glu317Lys Uncertain significance Single submitter
- ASB11 p.Gly154Arg Uncertain significance Single submitter
- ASB11 p.Gly43Glu Uncertain significance Single submitter
- ASB11 p.Leu163Pro Uncertain significance Single submitter
- ASB11 p.Leu183Met Uncertain significance Single submitter
- ASB11 p.Leu290Phe Uncertain significance Single submitter
- ASB11 p.Leu320Phe Uncertain significance Single submitter
- ASB11 p.Phe14Leu Uncertain significance Single submitter
- ASB11 p.Phe18Leu Uncertain significance Single submitter
- ASB11 p.Pro68Ser Uncertain significance Single submitter
- ASB11 p.Ser141Gly Uncertain significance Single submitter
- ASB11 p.Ser165Leu Likely benign Single submitter
- ASB11 p.Tyr322Cys Uncertain significance Single submitter
- ASB11 p.Tyr39Cys Uncertain significance Single submitter
- ASB11 p.Val127Met Uncertain significance Single submitter
- ASB11 p.Val274Met Uncertain significance Single submitter
All ASB11 variants
Benign 2
- p.Arg208Trp Multiple submitters ⚠
- p.Asp249Asn Multiple submitters ⚠
Likely benign 4
- c.847+6C>A Single submitter
- p.Arg256Leu Single submitter
- p.Leu228= Single submitter
- p.Ser165Leu Single submitter ⚠
Uncertain significance 41
- p.Arg256His Multiple submitters ⚠
- p.Ala114Gly Single submitter ⚠
- p.Ala145Thr Single submitter ⚠
- p.Ala259Gly Single submitter ⚠
- p.Ala268Val Single submitter ⚠
- p.Arg281Cys Single submitter ⚠
- p.Arg292Cys Single submitter ⚠
- p.Arg292Leu Single submitter ⚠
- p.Arg296Trp Single submitter ⚠
- p.Arg77Leu Single submitter ⚠
- p.Asn148Ile Single submitter ⚠
- p.Asn258Thr Single submitter ⚠
- p.Asp3Gly Single submitter ⚠
- p.Cys146Arg Single submitter ⚠
- p.Cys291Arg Single submitter ⚠
- p.Gln158Leu Single submitter ⚠
- p.Glu177Gln Single submitter ⚠
- p.Glu177Lys Single submitter ⚠
- p.Glu317Lys Single submitter ⚠
- p.Gly154Arg Single submitter ⚠
- p.Gly197Arg Single submitter ⚠
- p.Gly43Glu Single submitter ⚠
- p.Leu102= Single submitter
- p.Leu163Pro Single submitter ⚠
- p.Leu183Met Single submitter ⚠
- p.Leu290Phe Single submitter ⚠
- p.Leu320Phe Single submitter ⚠
- p.Phe14Leu Single submitter ⚠
- p.Phe18Leu Single submitter ⚠
- p.Pro5Leu Single submitter ⚠
- p.Pro68Ser Single submitter ⚠
- p.Ser141Gly Single submitter ⚠
- p.Thr20Met Single submitter ⚠
- p.Thr230Ser Single submitter ⚠
- p.Tyr322Cys Single submitter ⚠
- p.Tyr39Cys Single submitter ⚠
- p.Val127Met Single submitter ⚠
- p.Val274Met Single submitter ⚠
- p.Val41Ile Single submitter ⚠
- p.Val99Leu Single submitter ⚠
- p.Ile96fs No assertion criteria