ASB15 — 85 ClinVar variants
All ClinVar germline ASB15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 81 flagged for review →
4 Likely benign · 81 Uncertain significance
Full ASB15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 81
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 53
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ASB15 p.Ala194Thr Uncertain significance Single submitter
- ASB15 p.Ala250Thr Uncertain significance Single submitter
- ASB15 p.Ala558Val Uncertain significance Single submitter
- ASB15 p.Ala568Pro Uncertain significance Single submitter
- ASB15 p.Ala72Ser Uncertain significance Single submitter
- ASB15 p.Ala72Val Uncertain significance Single submitter
- ASB15 p.Arg274Gly Uncertain significance Single submitter
- ASB15 p.Arg417His Uncertain significance Single submitter
- ASB15 p.Arg522Ser Uncertain significance Single submitter
- ASB15 p.Arg542Trp Uncertain significance Single submitter
- ASB15 p.Asn167Asp Uncertain significance Single submitter
- ASB15 p.Asn391Ser Uncertain significance Single submitter
- ASB15 p.Asn479Lys Uncertain significance Single submitter
- ASB15 p.Asp171Asn Uncertain significance Single submitter
- ASB15 p.Asp348Asn Uncertain significance Single submitter
- ASB15 p.Asp348Glu Uncertain significance Single submitter
- ASB15 p.Cys511Arg Uncertain significance Single submitter
- ASB15 p.Cys535Tyr Uncertain significance Single submitter
- ASB15 p.Gln319His Uncertain significance Single submitter
- ASB15 p.Glu105Asp Uncertain significance Single submitter
- ASB15 p.Glu132Lys Uncertain significance Single submitter
- ASB15 p.Glu286Lys Uncertain significance Single submitter
- ASB15 p.Gly122Asp Uncertain significance Single submitter
- ASB15 p.Gly201Ser Uncertain significance Single submitter
- ASB15 p.Gly221Val Uncertain significance Single submitter
- ASB15 p.Gly287Arg Uncertain significance Single submitter
- ASB15 p.Gly373Val Uncertain significance Single submitter
- ASB15 p.Gly439Ala Uncertain significance Single submitter
- ASB15 p.Gly76Arg Uncertain significance Single submitter
- ASB15 p.His11Tyr Uncertain significance Single submitter
- ASB15 p.Ile164Val Uncertain significance Single submitter
- ASB15 p.Ile192Leu Uncertain significance Single submitter
- ASB15 p.Ile463Thr Uncertain significance Single submitter
- ASB15 p.Ile573Val Uncertain significance Single submitter
- ASB15 p.Leu247Gln Uncertain significance Single submitter
- ASB15 p.Leu326Val Uncertain significance Single submitter
- ASB15 p.Leu337Val Uncertain significance Single submitter
- ASB15 p.Leu40Val Uncertain significance Single submitter
- ASB15 p.Lys143Glu Uncertain significance Single submitter
- ASB15 p.Lys306Glu Uncertain significance Single submitter
- ASB15 p.Lys351Asn Uncertain significance Single submitter
- ASB15 p.Lys477Arg Uncertain significance Single submitter
- ASB15 p.Met444Ile Uncertain significance Single submitter
- ASB15 p.Phe458Ser Uncertain significance Single submitter
- ASB15 p.Pro279Ser Uncertain significance Single submitter
- ASB15 p.Ser473Pro Uncertain significance Single submitter
- ASB15 p.Thr30Ile Uncertain significance Single submitter
- ASB15 p.Trp524Arg Uncertain significance Single submitter
- ASB15 p.Val124Met Uncertain significance Single submitter
- ASB15 p.Val386Ala Uncertain significance Single submitter
- ASB15 p.Val388Ala Uncertain significance Single submitter
- ASB15 p.Val396Ala Uncertain significance Single submitter
- ASB15 p.Val396Phe Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- ASB15 p.Ala315Gly Uncertain significance Single submitter
- ASB15 p.Ala372Thr Uncertain significance Single submitter
- ASB15 p.Arg189Gln Uncertain significance Single submitter
- ASB15 p.Arg282Gln Uncertain significance Single submitter
- ASB15 p.Arg528Cys Uncertain significance Single submitter
- ASB15 p.Asn360Asp Uncertain significance Single submitter
- ASB15 p.Asn407Ser Uncertain significance Single submitter
- ASB15 p.Asp171Gly Uncertain significance Single submitter
- ASB15 p.Asp503Asn Uncertain significance Single submitter
- ASB15 p.Glu105Gly Uncertain significance Single submitter
- ASB15 p.Gly200Arg Uncertain significance Single submitter
- ASB15 p.His222Arg Uncertain significance Single submitter
- ASB15 p.Ile150Thr Uncertain significance Single submitter
- ASB15 p.Ile342Asn Uncertain significance Single submitter
- ASB15 p.Ile342Thr Uncertain significance Single submitter
- ASB15 p.Leu398Val Uncertain significance Single submitter
- ASB15 p.Leu435Phe Uncertain significance Single submitter
- ASB15 p.Leu59Phe Uncertain significance Single submitter
- ASB15 p.Met69Ile Uncertain significance Single submitter
- ASB15 p.Phe458Leu Uncertain significance Single submitter
- ASB15 p.Ser300Pro Uncertain significance Single submitter
- ASB15 p.Thr13Lys Uncertain significance Single submitter
- ASB15 p.Thr146Ser Uncertain significance Single submitter
- ASB15 p.Thr366Ala Uncertain significance Single submitter
- ASB15 p.Val119Leu Uncertain significance Single submitter
- ASB15 p.Val236Met Uncertain significance Single submitter
- ASB15 p.Val358Ile Uncertain significance Single submitter
- ASB15 p.Val494Leu Uncertain significance Single submitter
All ASB15 variants
Likely benign 4
- p.Arg305Gln Single submitter
- p.Asn382= Single submitter
- p.Leu237Phe Single submitter
- p.Val560Met Single submitter
Uncertain significance 81
- p.Ala194Thr Single submitter ⚠
- p.Ala250Thr Single submitter ⚠
- p.Ala315Gly Single submitter ⚠
- p.Ala372Thr Single submitter ⚠
- p.Ala558Val Single submitter ⚠
- p.Ala568Pro Single submitter ⚠
- p.Ala72Ser Single submitter ⚠
- p.Ala72Val Single submitter ⚠
- p.Arg189Gln Single submitter ⚠
- p.Arg274Gly Single submitter ⚠
- p.Arg282Gln Single submitter ⚠
- p.Arg417His Single submitter ⚠
- p.Arg522Ser Single submitter ⚠
- p.Arg528Cys Single submitter ⚠
- p.Arg542Trp Single submitter ⚠
- p.Asn167Asp Single submitter ⚠
- p.Asn360Asp Single submitter ⚠
- p.Asn391Ser Single submitter ⚠
- p.Asn407Ser Single submitter ⚠
- p.Asn479Lys Single submitter ⚠
- p.Asp171Asn Single submitter ⚠
- p.Asp171Gly Single submitter ⚠
- p.Asp348Asn Single submitter ⚠
- p.Asp348Glu Single submitter ⚠
- p.Asp503Asn Single submitter ⚠
- p.Cys511Arg Single submitter ⚠
- p.Cys535Tyr Single submitter ⚠
- p.Gln319His Single submitter ⚠
- p.Glu105Asp Single submitter ⚠
- p.Glu105Gly Single submitter ⚠
- p.Glu132Lys Single submitter ⚠
- p.Glu286Lys Single submitter ⚠
- p.Gly122Asp Single submitter ⚠
- p.Gly200Arg Single submitter ⚠
- p.Gly201Ser Single submitter ⚠
- p.Gly221Val Single submitter ⚠
- p.Gly287Arg Single submitter ⚠
- p.Gly373Val Single submitter ⚠
- p.Gly439Ala Single submitter ⚠
- p.Gly76Arg Single submitter ⚠
- p.His11Tyr Single submitter ⚠
- p.His222Arg Single submitter ⚠
- p.Ile150Thr Single submitter ⚠
- p.Ile164Val Single submitter ⚠
- p.Ile192Leu Single submitter ⚠
- p.Ile342Asn Single submitter ⚠
- p.Ile342Thr Single submitter ⚠
- p.Ile463Thr Single submitter ⚠
- p.Ile573Val Single submitter ⚠
- p.Leu247Gln Single submitter ⚠
- p.Leu326Val Single submitter ⚠
- p.Leu337Val Single submitter ⚠
- p.Leu398Val Single submitter ⚠
- p.Leu40Val Single submitter ⚠
- p.Leu435Phe Single submitter ⚠
- p.Leu59Phe Single submitter ⚠
- p.Lys143Glu Single submitter ⚠
- p.Lys306Glu Single submitter ⚠
- p.Lys351Asn Single submitter ⚠
- p.Lys477Arg Single submitter ⚠
- p.Met444Ile Single submitter ⚠
- p.Met69Ile Single submitter ⚠
- p.Phe458Leu Single submitter ⚠
- p.Phe458Ser Single submitter ⚠
- p.Pro279Ser Single submitter ⚠
- p.Ser300Pro Single submitter ⚠
- p.Ser473Pro Single submitter ⚠
- p.Thr13Lys Single submitter ⚠
- p.Thr146Ser Single submitter ⚠
- p.Thr30Ile Single submitter ⚠
- p.Thr366Ala Single submitter ⚠
- p.Trp524Arg Single submitter ⚠
- p.Val119Leu Single submitter ⚠
- p.Val124Met Single submitter ⚠
- p.Val236Met Single submitter ⚠
- p.Val358Ile Single submitter ⚠
- p.Val386Ala Single submitter ⚠
- p.Val388Ala Single submitter ⚠
- p.Val396Ala Single submitter ⚠
- p.Val396Phe Single submitter ⚠
- p.Val494Leu Single submitter ⚠