ASB16 — 114 ClinVar variants
All ClinVar germline ASB16 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 106 flagged for review →
1 Conflicting · 8 Likely benign · 105 Uncertain significance
Full ASB16 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 106
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ASB16 p.Ala200Pro Uncertain significance Single submitter
- ASB16 p.Ala396Thr Uncertain significance Single submitter
- ASB16 p.Ala415Thr Uncertain significance Single submitter
- ASB16 p.Arg121Gln Uncertain significance Single submitter
- ASB16 p.Arg121Pro Uncertain significance Single submitter
- ASB16 p.Arg140Cys Uncertain significance Single submitter
- ASB16 p.Arg220Cys Uncertain significance Single submitter
- ASB16 p.Arg261Gly Uncertain significance Single submitter
- ASB16 p.Arg268Leu Uncertain significance Single submitter
- ASB16 p.Arg28Gln Uncertain significance Single submitter
- ASB16 p.Arg305Gly Uncertain significance Single submitter
- ASB16 p.Arg37Gln Uncertain significance Single submitter
- ASB16 p.Arg420Gly Uncertain significance Single submitter
- ASB16 p.Arg422Gly Uncertain significance Single submitter
- ASB16 p.Arg426His Uncertain significance Single submitter
- ASB16 p.Arg433Gly Uncertain significance Single submitter
- ASB16 p.Arg433Trp Uncertain significance Single submitter
- ASB16 p.Arg447His Uncertain significance Single submitter
- ASB16 p.Arg46Gln Uncertain significance Single submitter
- ASB16 p.Arg48Gln Uncertain significance Single submitter
- ASB16 p.Arg57Gln Uncertain significance Single submitter
- ASB16 p.Asn333Ser Uncertain significance Single submitter
- ASB16 p.Asp442Glu Uncertain significance Single submitter
- ASB16 p.Cys403Tyr Uncertain significance Single submitter
- ASB16 p.Glu136Asp Uncertain significance Single submitter
- ASB16 p.Glu175Asp Uncertain significance Single submitter
- ASB16 p.Glu223Ala Uncertain significance Single submitter
- ASB16 p.Glu24Gln Uncertain significance Single submitter
- ASB16 p.Gly142Arg Uncertain significance Single submitter
- ASB16 p.Gly258Arg Uncertain significance Single submitter
- ASB16 p.Gly298Asp Uncertain significance Single submitter
- ASB16 p.His225Gln Uncertain significance Single submitter
- ASB16 p.Ile86Val Uncertain significance Single submitter
- ASB16 p.Leu228Pro Uncertain significance Single submitter
- ASB16 p.Leu247Gln Uncertain significance Single submitter
- ASB16 p.Leu325Pro Uncertain significance Single submitter
- ASB16 p.Leu356Pro Uncertain significance Single submitter
- ASB16 p.Met12Ile Uncertain significance Single submitter
- ASB16 p.Met85Thr Uncertain significance Single submitter
- ASB16 p.Phe340Ser Uncertain significance Single submitter
- ASB16 p.Pro320Ser Uncertain significance Single submitter
- ASB16 p.Pro438Arg Uncertain significance Single submitter
- ASB16 p.Pro7Leu Uncertain significance Single submitter
- ASB16 p.Trp22Arg Uncertain significance Single submitter
- ASB16 p.Val328Leu Uncertain significance Single submitter
Predictors split 60
The independent predictors disagree with each other — read with care.
- ASB16 p.Ala200Thr Uncertain significance Single submitter
- ASB16 p.Ala219Val Uncertain significance Single submitter
- ASB16 p.Ala252Pro Uncertain significance Single submitter
- ASB16 p.Ala254Thr Uncertain significance Single submitter
- ASB16 p.Ala273Gly Uncertain significance Single submitter
- ASB16 p.Ala291Thr Uncertain significance Single submitter
- ASB16 p.Ala310Thr Uncertain significance Single submitter
- ASB16 p.Ala316Val Uncertain significance Single submitter
- ASB16 p.Ala31Val Uncertain significance Single submitter
- ASB16 p.Ala360Ser Uncertain significance Single submitter
- ASB16 p.Ala360Thr Uncertain significance Single submitter
- ASB16 p.Ala415Gly Uncertain significance Single submitter
- ASB16 p.Ala415Val Uncertain significance Single submitter
- ASB16 p.Ala82Val Uncertain significance Single submitter
- ASB16 p.Ala83Thr Uncertain significance Single submitter
- ASB16 p.Arg128Gly Uncertain significance Single submitter
- ASB16 p.Arg144Cys Uncertain significance Single submitter
- ASB16 p.Arg144His Uncertain significance Single submitter
- ASB16 p.Arg268Cys Uncertain significance Single submitter
- ASB16 p.Arg284Cys Uncertain significance Single submitter
- ASB16 p.Arg29Trp Uncertain significance Single submitter
- ASB16 p.Arg37Trp Uncertain significance Single submitter
- ASB16 p.Arg39His Uncertain significance Single submitter
- ASB16 p.Arg416Gln Uncertain significance Single submitter
- ASB16 p.Arg420His Uncertain significance Single submitter
- ASB16 p.Arg422Trp Uncertain significance Single submitter
- ASB16 p.Arg426Cys Uncertain significance Single submitter
- ASB16 p.Arg433Pro Uncertain significance Single submitter
- ASB16 p.Arg46Trp Uncertain significance Single submitter
- ASB16 p.Asn294Asp Uncertain significance Single submitter
- ASB16 p.Asn314His Uncertain significance Single submitter
- ASB16 p.Asn314Ser Uncertain significance Single submitter
- ASB16 p.Asp276Asn Uncertain significance Single submitter
- ASB16 p.Cys359Gly Uncertain significance Single submitter
- ASB16 p.Glu175Lys Uncertain significance Single submitter
- ASB16 p.Glu187Lys Uncertain significance Single submitter
- ASB16 p.Glu272Gln Uncertain significance Single submitter
- ASB16 p.Glu301Lys Uncertain significance Single submitter
- ASB16 p.Glu337Lys Uncertain significance Single submitter
- ASB16 p.Gly101Glu Uncertain significance Single submitter
- ASB16 p.Gly143Cys Uncertain significance Single submitter
- ASB16 p.Gly166Arg Uncertain significance Single submitter
- ASB16 p.Gly317Asp Uncertain significance Single submitter
- ASB16 p.His225Pro Uncertain significance Single submitter
- ASB16 p.His413Tyr Uncertain significance Single submitter
- ASB16 p.Leu180Val Uncertain significance Single submitter
- ASB16 p.Leu299Pro Uncertain significance Single submitter
- ASB16 p.Met321Thr Uncertain significance Single submitter
- ASB16 p.Phe77Leu Uncertain significance Single submitter
- ASB16 p.Pro114Ser Uncertain significance Single submitter
- ASB16 p.Pro350Leu Uncertain significance Single submitter
- ASB16 p.Ser97Leu Uncertain significance Single submitter
- ASB16 p.Thr106Asn Uncertain significance Single submitter
- ASB16 p.Thr184Met Uncertain significance Single submitter
- ASB16 p.Thr212Met Uncertain significance Single submitter
- ASB16 p.Thr286Met Uncertain significance Single submitter
- ASB16 p.Thr319Lys Uncertain significance Single submitter
- ASB16 p.Thr432Ile Uncertain significance Single submitter
- ASB16 p.Val236Gly Uncertain significance Single submitter
- ASB16 p.Val386Met Uncertain significance Single submitter
All ASB16 variants
Conflicting classifications of pathogenicity 1
- p.Arg352His Single submitter ⚠
Likely benign 8
- p.Ala145Thr Single submitter
- p.Ala266Val Single submitter
- p.Ala31= Single submitter
- p.Ala324= Single submitter
- p.Arg28= Single submitter
- p.Arg30Gln Single submitter
- p.Leu180= Single submitter
- p.Leu387= Single submitter
Uncertain significance 105
- p.Ala200Pro Single submitter ⚠
- p.Ala200Thr Single submitter ⚠
- p.Ala219Val Single submitter ⚠
- p.Ala252Pro Single submitter ⚠
- p.Ala254Thr Single submitter ⚠
- p.Ala273Gly Single submitter ⚠
- p.Ala291Thr Single submitter ⚠
- p.Ala310Thr Single submitter ⚠
- p.Ala316Val Single submitter ⚠
- p.Ala31Val Single submitter ⚠
- p.Ala360Ser Single submitter ⚠
- p.Ala360Thr Single submitter ⚠
- p.Ala396Thr Single submitter ⚠
- p.Ala415Gly Single submitter ⚠
- p.Ala415Thr Single submitter ⚠
- p.Ala415Val Single submitter ⚠
- p.Ala82Val Single submitter ⚠
- p.Ala83Thr Single submitter ⚠
- p.Arg121Gln Single submitter ⚠
- p.Arg121Pro Single submitter ⚠
- p.Arg128Gly Single submitter ⚠
- p.Arg140Cys Single submitter ⚠
- p.Arg144Cys Single submitter ⚠
- p.Arg144His Single submitter ⚠
- p.Arg220Cys Single submitter ⚠
- p.Arg261Gly Single submitter ⚠
- p.Arg268Cys Single submitter ⚠
- p.Arg268Leu Single submitter ⚠
- p.Arg284Cys Single submitter ⚠
- p.Arg28Gln Single submitter ⚠
- p.Arg29Trp Single submitter ⚠
- p.Arg305Gly Single submitter ⚠
- p.Arg37Gln Single submitter ⚠
- p.Arg37Trp Single submitter ⚠
- p.Arg39His Single submitter ⚠
- p.Arg416Gln Single submitter ⚠
- p.Arg420Gly Single submitter ⚠
- p.Arg420His Single submitter ⚠
- p.Arg422Gly Single submitter ⚠
- p.Arg422Trp Single submitter ⚠
- p.Arg426Cys Single submitter ⚠
- p.Arg426His Single submitter ⚠
- p.Arg433Gly Single submitter ⚠
- p.Arg433Pro Single submitter ⚠
- p.Arg433Trp Single submitter ⚠
- p.Arg447His Single submitter ⚠
- p.Arg46Gln Single submitter ⚠
- p.Arg46Trp Single submitter ⚠
- p.Arg48Gln Single submitter ⚠
- p.Arg57Gln Single submitter ⚠
- p.Asn294Asp Single submitter ⚠
- p.Asn314His Single submitter ⚠
- p.Asn314Ser Single submitter ⚠
- p.Asn333Ser Single submitter ⚠
- p.Asp276Asn Single submitter ⚠
- p.Asp442Glu Single submitter ⚠
- p.Cys359Gly Single submitter ⚠
- p.Cys403Tyr Single submitter ⚠
- p.Glu136Asp Single submitter ⚠
- p.Glu175Asp Single submitter ⚠
- p.Glu175Lys Single submitter ⚠
- p.Glu187Lys Single submitter ⚠
- p.Glu223Ala Single submitter ⚠
- p.Glu24Gln Single submitter ⚠
- p.Glu272Gln Single submitter ⚠
- p.Glu301Lys Single submitter ⚠
- p.Glu337Lys Single submitter ⚠
- p.Gly101Glu Single submitter ⚠
- p.Gly142Arg Single submitter ⚠
- p.Gly143Cys Single submitter ⚠
- p.Gly166Arg Single submitter ⚠
- p.Gly258Arg Single submitter ⚠
- p.Gly298Asp Single submitter ⚠
- p.Gly317Asp Single submitter ⚠
- p.His225Gln Single submitter ⚠
- p.His225Pro Single submitter ⚠
- p.His413Tyr Single submitter ⚠
- p.Ile86Val Single submitter ⚠
- p.Leu180Val Single submitter ⚠
- p.Leu228Pro Single submitter ⚠
- p.Leu247Gln Single submitter ⚠
- p.Leu299Pro Single submitter ⚠
- p.Leu325Pro Single submitter ⚠
- p.Leu356Pro Single submitter ⚠
- p.Met12Ile Single submitter ⚠
- p.Met321Thr Single submitter ⚠
- p.Met85Thr Single submitter ⚠
- p.Phe340Ser Single submitter ⚠
- p.Phe77Leu Single submitter ⚠
- p.Pro114Ser Single submitter ⚠
- p.Pro320Ser Single submitter ⚠
- p.Pro350Leu Single submitter ⚠
- p.Pro438Arg Single submitter ⚠
- p.Pro7Leu Single submitter ⚠
- p.Ser97Leu Single submitter ⚠
- p.Thr106Asn Single submitter ⚠
- p.Thr184Met Single submitter ⚠
- p.Thr212Met Single submitter ⚠
- p.Thr286Met Single submitter ⚠
- p.Thr319Lys Single submitter ⚠
- p.Thr432Ile Single submitter ⚠
- p.Trp22Arg Single submitter ⚠
- p.Val236Gly Single submitter ⚠
- p.Val328Leu Single submitter ⚠
- p.Val386Met Single submitter ⚠