ASB17 — 34 ClinVar variants
All ClinVar germline ASB17 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
34 Uncertain significance
Full ASB17 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ASB17 p.Ala65Thr Uncertain significance Single submitter
- ASB17 p.Arg286Cys Uncertain significance Single submitter
- ASB17 p.Arg46Lys Uncertain significance Single submitter
- ASB17 p.Asn128Lys Uncertain significance Single submitter
- ASB17 p.Asp197Glu Uncertain significance Single submitter
- ASB17 p.Asp59Asn Uncertain significance Single submitter
- ASB17 p.Cys42Tyr Uncertain significance Single submitter
- ASB17 p.Cys93Arg Uncertain significance Single submitter
- ASB17 p.Glu82Gln Uncertain significance Single submitter
- ASB17 p.Gly106Cys Uncertain significance Single submitter
- ASB17 p.His204Leu Uncertain significance Single submitter
- ASB17 p.His235Leu Uncertain significance Single submitter
- ASB17 p.Ile132Met Uncertain significance Single submitter
- ASB17 p.Ile18Val Uncertain significance Single submitter
- ASB17 p.Ile203Thr Uncertain significance Single submitter
- ASB17 p.Leu211Ser Uncertain significance Single submitter
- ASB17 p.Lys10Thr Uncertain significance Single submitter
- ASB17 p.Ser126Thr Uncertain significance Single submitter
- ASB17 p.Thr118Ile Uncertain significance Single submitter
- ASB17 p.Thr11Ile Uncertain significance Single submitter
- ASB17 p.Thr270Ser Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- ASB17 p.Asp64Glu Uncertain significance Single submitter
- ASB17 p.Cys260Ser Uncertain significance Single submitter
- ASB17 p.Glu255Lys Uncertain significance Single submitter
- ASB17 p.Ile185Thr Uncertain significance Single submitter
- ASB17 p.Ile47Phe Uncertain significance Single submitter
- ASB17 p.Leu60Ser Uncertain significance Single submitter
- ASB17 p.Pro138Leu Uncertain significance Single submitter
- ASB17 p.Ser143Arg Uncertain significance Single submitter
- ASB17 p.Thr263Ile Uncertain significance Single submitter
- ASB17 p.Tyr40Cys Uncertain significance Single submitter
- ASB17 p.Tyr43His Uncertain significance Single submitter
- ASB17 p.Val101Asp Uncertain significance Single submitter
- ASB17 p.Val217Ala Uncertain significance Single submitter
All ASB17 variants
Uncertain significance 34
- p.Ala65Thr Single submitter ⚠
- p.Arg286Cys Single submitter ⚠
- p.Arg46Lys Single submitter ⚠
- p.Asn128Lys Single submitter ⚠
- p.Asp197Glu Single submitter ⚠
- p.Asp59Asn Single submitter ⚠
- p.Asp64Glu Single submitter ⚠
- p.Cys260Ser Single submitter ⚠
- p.Cys42Tyr Single submitter ⚠
- p.Cys93Arg Single submitter ⚠
- p.Glu255Lys Single submitter ⚠
- p.Glu82Gln Single submitter ⚠
- p.Gly106Cys Single submitter ⚠
- p.His204Leu Single submitter ⚠
- p.His235Leu Single submitter ⚠
- p.Ile132Met Single submitter ⚠
- p.Ile185Thr Single submitter ⚠
- p.Ile18Val Single submitter ⚠
- p.Ile203Thr Single submitter ⚠
- p.Ile47Phe Single submitter ⚠
- p.Leu211Ser Single submitter ⚠
- p.Leu60Ser Single submitter ⚠
- p.Lys10Thr Single submitter ⚠
- p.Pro138Leu Single submitter ⚠
- p.Ser126Thr Single submitter ⚠
- p.Ser143Arg Single submitter ⚠
- p.Thr118Ile Single submitter ⚠
- p.Thr11Ile Single submitter ⚠
- p.Thr263Ile Single submitter ⚠
- p.Thr270Ser Single submitter ⚠
- p.Tyr40Cys Single submitter ⚠
- p.Tyr43His Single submitter ⚠
- p.Val101Asp Single submitter ⚠
- p.Val217Ala Single submitter ⚠