ASB18 — 93 ClinVar variants
All ClinVar germline ASB18 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 92 flagged for review →
1 Likely benign · 92 Uncertain significance
Full ASB18 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 92
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ASB18 p.Ala134Thr Uncertain significance Single submitter
- ASB18 p.Ala321Gly Uncertain significance Single submitter
- ASB18 p.Ala45Ser Uncertain significance Single submitter
- ASB18 p.Arg241His Uncertain significance Single submitter
- ASB18 p.Arg264Trp Uncertain significance Single submitter
- ASB18 p.Arg310Cys Uncertain significance Single submitter
- ASB18 p.Arg347His Uncertain significance Single submitter
- ASB18 p.Asp232His Uncertain significance Single submitter
- ASB18 p.Asp323Ala Uncertain significance Single submitter
- ASB18 p.Asp72Asn Uncertain significance Single submitter
- ASB18 p.Cys167Tyr Uncertain significance Single submitter
- ASB18 p.Cys192Arg Uncertain significance Single submitter
- ASB18 p.Cys200Tyr Uncertain significance Single submitter
- ASB18 p.Gln462Arg Uncertain significance Single submitter
- ASB18 p.Glu206Ala Uncertain significance Single submitter
- ASB18 p.Glu291Gln Uncertain significance Single submitter
- ASB18 p.Gly199Arg Uncertain significance Single submitter
- ASB18 p.Gly215Ala Uncertain significance Single submitter
- ASB18 p.Gly326Trp Uncertain significance Single submitter
- ASB18 p.Gly65Ser Uncertain significance Single submitter
- ASB18 p.His426Arg Uncertain significance Single submitter
- ASB18 p.Ile399Val Uncertain significance Single submitter
- ASB18 p.Leu189Pro Uncertain significance Single submitter
- ASB18 p.Leu223Arg Uncertain significance Single submitter
- ASB18 p.Leu313Gln Uncertain significance Single submitter
- ASB18 p.Leu341Arg Uncertain significance Single submitter
- ASB18 p.Lys367Arg Uncertain significance Single submitter
- ASB18 p.Lys75Arg Uncertain significance Single submitter
- ASB18 p.Met66Thr Uncertain significance Single submitter
- ASB18 p.Pro42Ser Uncertain significance Single submitter
- ASB18 p.Ser149Arg Uncertain significance Single submitter
- ASB18 p.Ser59Leu Uncertain significance Single submitter
- ASB18 p.Thr113Asn Uncertain significance Single submitter
- ASB18 p.Thr217Arg Uncertain significance Single submitter
- ASB18 p.Thr217Pro Uncertain significance Single submitter
- ASB18 p.Tyr116Asn Uncertain significance Single submitter
- ASB18 p.Val375Leu Uncertain significance Single submitter
- ASB18 p.Val88Leu Uncertain significance Single submitter
Predictors split 54
The independent predictors disagree with each other — read with care.
- ASB18 p.Ala127Thr Uncertain significance Single submitter
- ASB18 p.Ala166Pro Uncertain significance Single submitter
- ASB18 p.Ala187Glu Uncertain significance Single submitter
- ASB18 p.Ala196Thr Uncertain significance Single submitter
- ASB18 p.Ala288Gly Uncertain significance Single submitter
- ASB18 p.Ala317Thr Uncertain significance Single submitter
- ASB18 p.Arg118Cys Uncertain significance Single submitter
- ASB18 p.Arg118Leu Uncertain significance Single submitter
- ASB18 p.Arg193Gly Uncertain significance Single submitter
- ASB18 p.Arg193Leu Uncertain significance Single submitter
- ASB18 p.Arg213His Uncertain significance Single submitter
- ASB18 p.Arg219Trp Uncertain significance Single submitter
- ASB18 p.Arg236Leu Uncertain significance Single submitter
- ASB18 p.Arg289Cys Uncertain significance Single submitter
- ASB18 p.Arg332Gly Uncertain significance Single submitter
- ASB18 p.Arg429His Uncertain significance Single submitter
- ASB18 p.Arg433Cys Uncertain significance Single submitter
- ASB18 p.Arg433His Uncertain significance Single submitter
- ASB18 p.Arg434Gly Uncertain significance Single submitter
- ASB18 p.Arg439Thr Uncertain significance Single submitter
- ASB18 p.Asn86Ile Uncertain significance Single submitter
- ASB18 p.Asp147Tyr Uncertain significance Single submitter
- ASB18 p.Asp177Asn Uncertain significance Single submitter
- ASB18 p.Asp220Asn Uncertain significance Single submitter
- ASB18 p.Asp287Asn Uncertain significance Single submitter
- ASB18 p.Glu233Lys Uncertain significance Single submitter
- ASB18 p.Gly162Glu Uncertain significance Single submitter
- ASB18 p.Gly208Trp Uncertain significance Single submitter
- ASB18 p.Gly216Ser Uncertain significance Single submitter
- ASB18 p.Gly463Ser Uncertain significance Single submitter
- ASB18 p.His174Tyr Uncertain significance Single submitter
- ASB18 p.His426Tyr Uncertain significance Single submitter
- ASB18 p.Leu156Pro Uncertain significance Single submitter
- ASB18 p.Leu311Phe Uncertain significance Single submitter
- ASB18 p.Leu313Arg Uncertain significance Single submitter
- ASB18 p.Leu35Phe Uncertain significance Single submitter
- ASB18 p.Leu391Phe Uncertain significance Single submitter
- ASB18 p.Phe89Ser Uncertain significance Single submitter
- ASB18 p.Pro146Gln Uncertain significance Single submitter
- ASB18 p.Pro345Leu Uncertain significance Single submitter
- ASB18 p.Pro366Leu Uncertain significance Single submitter
- ASB18 p.Pro400Leu Uncertain significance Single submitter
- ASB18 p.Pro421Leu Uncertain significance Single submitter
- ASB18 p.Pro461Ser Uncertain significance Single submitter
- ASB18 p.Ser295Arg Uncertain significance Single submitter
- ASB18 p.Ser357Phe Uncertain significance Single submitter
- ASB18 p.Ser413Phe Uncertain significance Single submitter
- ASB18 p.Thr133Asn Uncertain significance Single submitter
- ASB18 p.Thr165Asn Uncertain significance Single submitter
- ASB18 p.Thr217Met Uncertain significance Single submitter
- ASB18 p.Thr254Met Uncertain significance Single submitter
- ASB18 p.Val225Glu Uncertain significance Single submitter
- ASB18 p.Val43Gly Uncertain significance Single submitter
- ASB18 p.Gly283Arg Uncertain significance No assertion criteria
All ASB18 variants
Likely benign 1
- p.Asn13Ser Single submitter
Uncertain significance 92
- p.Ala127Thr Single submitter ⚠
- p.Ala134Thr Single submitter ⚠
- p.Ala166Pro Single submitter ⚠
- p.Ala187Glu Single submitter ⚠
- p.Ala196Thr Single submitter ⚠
- p.Ala288Gly Single submitter ⚠
- p.Ala317Thr Single submitter ⚠
- p.Ala321Gly Single submitter ⚠
- p.Ala45Ser Single submitter ⚠
- p.Arg118Cys Single submitter ⚠
- p.Arg118Leu Single submitter ⚠
- p.Arg193Gly Single submitter ⚠
- p.Arg193Leu Single submitter ⚠
- p.Arg213His Single submitter ⚠
- p.Arg219Trp Single submitter ⚠
- p.Arg236Leu Single submitter ⚠
- p.Arg241His Single submitter ⚠
- p.Arg264Trp Single submitter ⚠
- p.Arg289Cys Single submitter ⚠
- p.Arg310Cys Single submitter ⚠
- p.Arg332Gly Single submitter ⚠
- p.Arg347His Single submitter ⚠
- p.Arg429His Single submitter ⚠
- p.Arg433Cys Single submitter ⚠
- p.Arg433His Single submitter ⚠
- p.Arg434Gly Single submitter ⚠
- p.Arg439Thr Single submitter ⚠
- p.Asn86Ile Single submitter ⚠
- p.Asp147Tyr Single submitter ⚠
- p.Asp177Asn Single submitter ⚠
- p.Asp220Asn Single submitter ⚠
- p.Asp232His Single submitter ⚠
- p.Asp287Asn Single submitter ⚠
- p.Asp323Ala Single submitter ⚠
- p.Asp72Asn Single submitter ⚠
- p.Cys167Tyr Single submitter ⚠
- p.Cys192Arg Single submitter ⚠
- p.Cys200Tyr Single submitter ⚠
- p.Gln462Arg Single submitter ⚠
- p.Glu206Ala Single submitter ⚠
- p.Glu233Lys Single submitter ⚠
- p.Glu291Gln Single submitter ⚠
- p.Gly162Glu Single submitter ⚠
- p.Gly199Arg Single submitter ⚠
- p.Gly208Trp Single submitter ⚠
- p.Gly215Ala Single submitter ⚠
- p.Gly216Ser Single submitter ⚠
- p.Gly326Trp Single submitter ⚠
- p.Gly463Ser Single submitter ⚠
- p.Gly65Ser Single submitter ⚠
- p.His174Tyr Single submitter ⚠
- p.His426Arg Single submitter ⚠
- p.His426Tyr Single submitter ⚠
- p.Ile399Val Single submitter ⚠
- p.Leu156Pro Single submitter ⚠
- p.Leu189Pro Single submitter ⚠
- p.Leu223Arg Single submitter ⚠
- p.Leu311Phe Single submitter ⚠
- p.Leu313Arg Single submitter ⚠
- p.Leu313Gln Single submitter ⚠
- p.Leu341Arg Single submitter ⚠
- p.Leu35Phe Single submitter ⚠
- p.Leu391Phe Single submitter ⚠
- p.Lys367Arg Single submitter ⚠
- p.Lys75Arg Single submitter ⚠
- p.Met66Thr Single submitter ⚠
- p.Phe89Ser Single submitter ⚠
- p.Pro146Gln Single submitter ⚠
- p.Pro345Leu Single submitter ⚠
- p.Pro366Leu Single submitter ⚠
- p.Pro400Leu Single submitter ⚠
- p.Pro421Leu Single submitter ⚠
- p.Pro42Ser Single submitter ⚠
- p.Pro461Ser Single submitter ⚠
- p.Ser149Arg Single submitter ⚠
- p.Ser295Arg Single submitter ⚠
- p.Ser357Phe Single submitter ⚠
- p.Ser413Phe Single submitter ⚠
- p.Ser59Leu Single submitter ⚠
- p.Thr113Asn Single submitter ⚠
- p.Thr133Asn Single submitter ⚠
- p.Thr165Asn Single submitter ⚠
- p.Thr217Arg Single submitter ⚠
- p.Thr217Met Single submitter ⚠
- p.Thr217Pro Single submitter ⚠
- p.Thr254Met Single submitter ⚠
- p.Tyr116Asn Single submitter ⚠
- p.Val225Glu Single submitter ⚠
- p.Val375Leu Single submitter ⚠
- p.Val43Gly Single submitter ⚠
- p.Val88Leu Single submitter ⚠
- p.Gly283Arg No assertion criteria ⚠