ASB5 — 53 ClinVar variants
All ClinVar germline ASB5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 52 flagged for review →
1 Likely benign · 52 Uncertain significance
Full ASB5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 52
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ASB5 p.Ala175Thr Uncertain significance Single submitter
- ASB5 p.Ala51Pro Uncertain significance Single submitter
- ASB5 p.Ala85Thr Uncertain significance Single submitter
- ASB5 p.Asn142Lys Uncertain significance Single submitter
- ASB5 p.Asn16Ser Uncertain significance Single submitter
- ASB5 p.Asn263Ile Uncertain significance Single submitter
- ASB5 p.Gln63Pro Uncertain significance Single submitter
- ASB5 p.Gly126Glu Uncertain significance Single submitter
- ASB5 p.Gly224Asp Uncertain significance Single submitter
- ASB5 p.Gly256Val Uncertain significance Single submitter
- ASB5 p.Gly93Val Uncertain significance Single submitter
- ASB5 p.His286Tyr Uncertain significance Single submitter
- ASB5 p.Ile270Arg Uncertain significance Single submitter
- ASB5 p.Leu220Phe Uncertain significance Single submitter
- ASB5 p.Leu22Phe Uncertain significance Single submitter
- ASB5 p.Leu299Pro Uncertain significance Single submitter
- ASB5 p.Leu89Ser Uncertain significance Single submitter
- ASB5 p.Leu90Ser Uncertain significance Single submitter
- ASB5 p.Lys219Thr Uncertain significance Single submitter
- ASB5 p.Lys28Arg Uncertain significance Single submitter
- ASB5 p.Lys49Gln Uncertain significance Single submitter
- ASB5 p.Phe325Tyr Uncertain significance Single submitter
- ASB5 p.Ser150Arg Uncertain significance Single submitter
- ASB5 p.Ser244Pro Uncertain significance Single submitter
- ASB5 p.Ser72Thr Uncertain significance Single submitter
- ASB5 p.Thr133Met Uncertain significance Single submitter
- ASB5 p.Thr235Ile Uncertain significance Single submitter
- ASB5 p.Tyr232His Uncertain significance Single submitter
- ASB5 p.Tyr294His Uncertain significance Single submitter
- ASB5 p.Tyr94His Uncertain significance Single submitter
- ASB5 p.Val272Ala Uncertain significance Single submitter
- ASB5 p.Val3Ala Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- ASB5 p.Ala176Ser Uncertain significance Single submitter
- ASB5 p.Ala69Val Uncertain significance Single submitter
- ASB5 p.Ala77Ser Uncertain significance Single submitter
- ASB5 p.Arg302Gln Uncertain significance Single submitter
- ASB5 p.Asn142Ser Uncertain significance Single submitter
- ASB5 p.Glu124Val Uncertain significance Single submitter
- ASB5 p.Glu153Gly Uncertain significance Single submitter
- ASB5 p.Gly136Ser Uncertain significance Single submitter
- ASB5 p.Gly93Ser Uncertain significance Single submitter
- ASB5 p.Ile134Thr Uncertain significance Single submitter
- ASB5 p.Ile43Arg Uncertain significance Single submitter
- ASB5 p.Leu205Val Uncertain significance Single submitter
- ASB5 p.Leu296Val Uncertain significance Single submitter
- ASB5 p.Leu312Arg Uncertain significance Single submitter
- ASB5 p.Leu83Phe Uncertain significance Single submitter
- ASB5 p.Lys231Glu Uncertain significance Single submitter
- ASB5 p.Thr320Met Uncertain significance Single submitter
- ASB5 p.Val227Ile Uncertain significance Single submitter
- ASB5 p.Val44Ala Uncertain significance Single submitter
- ASB5 p.Val96Ile Uncertain significance Single submitter
All ASB5 variants
Likely benign 1
- p.Ile259Thr Single submitter
Uncertain significance 52
- p.Ala175Thr Single submitter ⚠
- p.Ala176Ser Single submitter ⚠
- p.Ala51Pro Single submitter ⚠
- p.Ala69Val Single submitter ⚠
- p.Ala77Ser Single submitter ⚠
- p.Ala85Thr Single submitter ⚠
- p.Arg302Gln Single submitter ⚠
- p.Asn142Lys Single submitter ⚠
- p.Asn142Ser Single submitter ⚠
- p.Asn16Ser Single submitter ⚠
- p.Asn263Ile Single submitter ⚠
- p.Gln63Pro Single submitter ⚠
- p.Glu124Val Single submitter ⚠
- p.Glu153Gly Single submitter ⚠
- p.Gly126Glu Single submitter ⚠
- p.Gly136Ser Single submitter ⚠
- p.Gly224Asp Single submitter ⚠
- p.Gly256Val Single submitter ⚠
- p.Gly93Ser Single submitter ⚠
- p.Gly93Val Single submitter ⚠
- p.His286Tyr Single submitter ⚠
- p.Ile134Thr Single submitter ⚠
- p.Ile270Arg Single submitter ⚠
- p.Ile43Arg Single submitter ⚠
- p.Leu205Val Single submitter ⚠
- p.Leu220Phe Single submitter ⚠
- p.Leu22Phe Single submitter ⚠
- p.Leu296Val Single submitter ⚠
- p.Leu299Pro Single submitter ⚠
- p.Leu312Arg Single submitter ⚠
- p.Leu83Phe Single submitter ⚠
- p.Leu89Ser Single submitter ⚠
- p.Leu90Ser Single submitter ⚠
- p.Lys219Thr Single submitter ⚠
- p.Lys231Glu Single submitter ⚠
- p.Lys28Arg Single submitter ⚠
- p.Lys49Gln Single submitter ⚠
- p.Phe325Tyr Single submitter ⚠
- p.Ser150Arg Single submitter ⚠
- p.Ser244Pro Single submitter ⚠
- p.Ser72Thr Single submitter ⚠
- p.Thr133Met Single submitter ⚠
- p.Thr235Ile Single submitter ⚠
- p.Thr320Met Single submitter ⚠
- p.Tyr232His Single submitter ⚠
- p.Tyr294His Single submitter ⚠
- p.Tyr94His Single submitter ⚠
- p.Val227Ile Single submitter ⚠
- p.Val272Ala Single submitter ⚠
- p.Val3Ala Single submitter ⚠
- p.Val44Ala Single submitter ⚠
- p.Val96Ile Single submitter ⚠