ASB6 — 76 ClinVar variants
All ClinVar germline ASB6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
7 Likely benign · 69 Uncertain significance
Full ASB6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ASB6 p.Ala167Thr Uncertain significance Single submitter
- ASB6 p.Ala286Thr Uncertain significance Single submitter
- ASB6 p.Ala43Ser Uncertain significance Single submitter
- ASB6 p.Ala72Thr Uncertain significance Single submitter
- ASB6 p.Ala84Val Uncertain significance Single submitter
- ASB6 p.Ala93Thr Uncertain significance Single submitter
- ASB6 p.Arg113Gln Uncertain significance Single submitter
- ASB6 p.Arg131Gln Uncertain significance Single submitter
- ASB6 p.Arg306Lys Uncertain significance Single submitter
- ASB6 p.Arg384Trp Uncertain significance Single submitter
- ASB6 p.Asn236Lys Uncertain significance Single submitter
- ASB6 p.Asn71Ser Uncertain significance Single submitter
- ASB6 p.Asn94Ser Uncertain significance Single submitter
- ASB6 p.Asp347Asn Uncertain significance Single submitter
- ASB6 p.Asp419Asn Uncertain significance Single submitter
- ASB6 p.Asp419Tyr Uncertain significance Single submitter
- ASB6 p.Cys313Ser Uncertain significance Single submitter
- ASB6 p.Gln367Glu Uncertain significance Single submitter
- ASB6 p.Glu356Gly Uncertain significance Single submitter
- ASB6 p.Gly227Arg Uncertain significance Single submitter
- ASB6 p.Gly415Ser Uncertain significance Single submitter
- ASB6 p.His108Tyr Uncertain significance Single submitter
- ASB6 p.His177Leu Uncertain significance Single submitter
- ASB6 p.Ile109Thr Uncertain significance Single submitter
- ASB6 p.Ile109Val Uncertain significance Single submitter
- ASB6 p.Ile302Val Uncertain significance Single submitter
- ASB6 p.Leu143Val Uncertain significance Single submitter
- ASB6 p.Leu401Gln Uncertain significance Single submitter
- ASB6 p.Lys208Glu Uncertain significance Single submitter
- ASB6 p.Lys325Glu Uncertain significance Single submitter
- ASB6 p.Met234Ile Uncertain significance Single submitter
- ASB6 p.Met234Val Uncertain significance Single submitter
- ASB6 p.Pro275Ser Uncertain significance Single submitter
- ASB6 p.Pro311Ser Uncertain significance Single submitter
- ASB6 p.Pro373Leu Uncertain significance Single submitter
- ASB6 p.Ser411Cys Uncertain significance Single submitter
- ASB6 p.Ser414Thr Uncertain significance Single submitter
- ASB6 p.Thr212Ile Uncertain significance Single submitter
Predictors split 31
The independent predictors disagree with each other — read with care.
- ASB6 p.Ala355Val Uncertain significance Single submitter
- ASB6 p.Ala77Val Uncertain significance Single submitter
- ASB6 p.Ala85Ser Uncertain significance Single submitter
- ASB6 p.Arg194His Uncertain significance Single submitter
- ASB6 p.Arg237Gly Uncertain significance Single submitter
- ASB6 p.Arg278Cys Uncertain significance Single submitter
- ASB6 p.Arg324Cys Uncertain significance Single submitter
- ASB6 p.Arg384Gln Uncertain significance Single submitter
- ASB6 p.Arg83Trp Uncertain significance Single submitter
- ASB6 p.Glu146Lys Uncertain significance Single submitter
- ASB6 p.Glu260Lys Uncertain significance Single submitter
- ASB6 p.Glu327Asp Uncertain significance Single submitter
- ASB6 p.Glu344Lys Uncertain significance Single submitter
- ASB6 p.Gly161Ala Uncertain significance Single submitter
- ASB6 p.Gly184Arg Uncertain significance Single submitter
- ASB6 p.Gly250Arg Uncertain significance Single submitter
- ASB6 p.Leu322Ile Uncertain significance Single submitter
- ASB6 p.Leu361Phe Uncertain significance Single submitter
- ASB6 p.Pro116Leu Uncertain significance Single submitter
- ASB6 p.Ser145Gly Uncertain significance Single submitter
- ASB6 p.Ser182Gly Uncertain significance Single submitter
- ASB6 p.Ser24Phe Uncertain significance Single submitter
- ASB6 p.Thr105Met Uncertain significance Single submitter
- ASB6 p.Thr314Met Uncertain significance Single submitter
- ASB6 p.Thr335Ile Uncertain significance Single submitter
- ASB6 p.Thr82Met Uncertain significance Single submitter
- ASB6 p.Val123Ala Uncertain significance Single submitter
- ASB6 p.Val203Ile Uncertain significance Single submitter
- ASB6 p.Val213Met Uncertain significance Single submitter
- ASB6 p.Val396Leu Uncertain significance Single submitter
- ASB6 p.Val87Ile Uncertain significance Single submitter
All ASB6 variants
Likely benign 7
- p.Val225= Multiple submitters
- p.Ala320Val Single submitter
- p.Arg244Gln Single submitter
- p.Glu230= Single submitter
- p.Ser182= Single submitter
- p.Thr190= Single submitter
- p.Thr215= Single submitter
Uncertain significance 69
- p.Ala167Thr Single submitter ⚠
- p.Ala286Thr Single submitter ⚠
- p.Ala355Val Single submitter ⚠
- p.Ala43Ser Single submitter ⚠
- p.Ala72Thr Single submitter ⚠
- p.Ala77Val Single submitter ⚠
- p.Ala84Val Single submitter ⚠
- p.Ala85Ser Single submitter ⚠
- p.Ala93Thr Single submitter ⚠
- p.Arg113Gln Single submitter ⚠
- p.Arg131Gln Single submitter ⚠
- p.Arg194His Single submitter ⚠
- p.Arg237Gly Single submitter ⚠
- p.Arg278Cys Single submitter ⚠
- p.Arg306Lys Single submitter ⚠
- p.Arg324Cys Single submitter ⚠
- p.Arg384Gln Single submitter ⚠
- p.Arg384Trp Single submitter ⚠
- p.Arg83Trp Single submitter ⚠
- p.Asn236Lys Single submitter ⚠
- p.Asn71Ser Single submitter ⚠
- p.Asn94Ser Single submitter ⚠
- p.Asp347Asn Single submitter ⚠
- p.Asp419Asn Single submitter ⚠
- p.Asp419Tyr Single submitter ⚠
- p.Cys313Ser Single submitter ⚠
- p.Gln367Glu Single submitter ⚠
- p.Glu146Lys Single submitter ⚠
- p.Glu260Lys Single submitter ⚠
- p.Glu327Asp Single submitter ⚠
- p.Glu344Lys Single submitter ⚠
- p.Glu356Gly Single submitter ⚠
- p.Gly161Ala Single submitter ⚠
- p.Gly184Arg Single submitter ⚠
- p.Gly227Arg Single submitter ⚠
- p.Gly250Arg Single submitter ⚠
- p.Gly415Ser Single submitter ⚠
- p.His108Tyr Single submitter ⚠
- p.His177Leu Single submitter ⚠
- p.Ile109Thr Single submitter ⚠
- p.Ile109Val Single submitter ⚠
- p.Ile302Val Single submitter ⚠
- p.Leu143Val Single submitter ⚠
- p.Leu322Ile Single submitter ⚠
- p.Leu361Phe Single submitter ⚠
- p.Leu401Gln Single submitter ⚠
- p.Lys208Glu Single submitter ⚠
- p.Lys325Glu Single submitter ⚠
- p.Met234Ile Single submitter ⚠
- p.Met234Val Single submitter ⚠
- p.Pro116Leu Single submitter ⚠
- p.Pro275Ser Single submitter ⚠
- p.Pro311Ser Single submitter ⚠
- p.Pro373Leu Single submitter ⚠
- p.Ser145Gly Single submitter ⚠
- p.Ser182Gly Single submitter ⚠
- p.Ser24Phe Single submitter ⚠
- p.Ser411Cys Single submitter ⚠
- p.Ser414Thr Single submitter ⚠
- p.Thr105Met Single submitter ⚠
- p.Thr212Ile Single submitter ⚠
- p.Thr314Met Single submitter ⚠
- p.Thr335Ile Single submitter ⚠
- p.Thr82Met Single submitter ⚠
- p.Val123Ala Single submitter ⚠
- p.Val203Ile Single submitter ⚠
- p.Val213Met Single submitter ⚠
- p.Val396Leu Single submitter ⚠
- p.Val87Ile Single submitter ⚠