ASB8 — 40 ClinVar variants
All ClinVar germline ASB8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
1 Likely benign · 39 Uncertain significance
Full ASB8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ASB8 p.Ala125Glu Uncertain significance Single submitter
- ASB8 p.Ala142Thr Uncertain significance Single submitter
- ASB8 p.Ala175Thr Uncertain significance Single submitter
- ASB8 p.Ala254Thr Uncertain significance Single submitter
- ASB8 p.Ala278Pro Uncertain significance Single submitter
- ASB8 p.Arg21Gly Uncertain significance Single submitter
- ASB8 p.Arg228Gln Uncertain significance Single submitter
- ASB8 p.Asn151Ser Uncertain significance Single submitter
- ASB8 p.Asn36Asp Uncertain significance Single submitter
- ASB8 p.Asp148Tyr Uncertain significance Single submitter
- ASB8 p.Asp269Asn Uncertain significance Single submitter
- ASB8 p.Asp46Tyr Uncertain significance Single submitter
- ASB8 p.Asp65Val Uncertain significance Single submitter
- ASB8 p.Gly200Ala Uncertain significance Single submitter
- ASB8 p.Gly43Arg Uncertain significance Single submitter
- ASB8 p.Gly52Cys Uncertain significance Single submitter
- ASB8 p.Leu122Phe Uncertain significance Single submitter
- ASB8 p.Leu264Pro Uncertain significance Single submitter
- ASB8 p.Lys203Arg Uncertain significance Single submitter
- ASB8 p.Met5Thr Uncertain significance Single submitter
- ASB8 p.Pro234Ala Uncertain significance Single submitter
- ASB8 p.Pro268Ser Uncertain significance Single submitter
- ASB8 p.Ser166Cys Uncertain significance Single submitter
- ASB8 p.Thr201Lys Uncertain significance Single submitter
- ASB8 p.Val258Leu Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- ASB8 p.Arg135Gln Uncertain significance Single submitter
- ASB8 p.Arg190His Uncertain significance Single submitter
- ASB8 p.Arg21Cys Uncertain significance Single submitter
- ASB8 p.Arg24Gln Uncertain significance Single submitter
- ASB8 p.Arg255Cys Uncertain significance Single submitter
- ASB8 p.Arg260Pro Uncertain significance Single submitter
- ASB8 p.Asn110Ile Uncertain significance Single submitter
- ASB8 p.Asn110Ser Uncertain significance Single submitter
- ASB8 p.Cys68Arg Uncertain significance Single submitter
- ASB8 p.Gly84Val Uncertain significance Single submitter
- ASB8 p.Ile12Thr Uncertain significance Single submitter
- ASB8 p.Leu243Val Uncertain significance Single submitter
- ASB8 p.Ser4Cys Uncertain significance Single submitter
- ASB8 p.Val63Met Uncertain significance Single submitter
All ASB8 variants
Likely benign 1
- p.Ala254Ser Single submitter
Uncertain significance 39
- p.Ala125Glu Single submitter ⚠
- p.Ala142Thr Single submitter ⚠
- p.Ala175Thr Single submitter ⚠
- p.Ala254Thr Single submitter ⚠
- p.Ala278Pro Single submitter ⚠
- p.Arg135Gln Single submitter ⚠
- p.Arg190His Single submitter ⚠
- p.Arg21Cys Single submitter ⚠
- p.Arg21Gly Single submitter ⚠
- p.Arg228Gln Single submitter ⚠
- p.Arg24Gln Single submitter ⚠
- p.Arg255Cys Single submitter ⚠
- p.Arg260Pro Single submitter ⚠
- p.Asn110Ile Single submitter ⚠
- p.Asn110Ser Single submitter ⚠
- p.Asn151Ser Single submitter ⚠
- p.Asn36Asp Single submitter ⚠
- p.Asp148Tyr Single submitter ⚠
- p.Asp269Asn Single submitter ⚠
- p.Asp46Tyr Single submitter ⚠
- p.Asp65Val Single submitter ⚠
- p.Cys68Arg Single submitter ⚠
- p.Gly200Ala Single submitter ⚠
- p.Gly43Arg Single submitter ⚠
- p.Gly52Cys Single submitter ⚠
- p.Gly84Val Single submitter ⚠
- p.Ile12Thr Single submitter ⚠
- p.Leu122Phe Single submitter ⚠
- p.Leu243Val Single submitter ⚠
- p.Leu264Pro Single submitter ⚠
- p.Lys203Arg Single submitter ⚠
- p.Met5Thr Single submitter ⚠
- p.Pro234Ala Single submitter ⚠
- p.Pro268Ser Single submitter ⚠
- p.Ser166Cys Single submitter ⚠
- p.Ser4Cys Single submitter ⚠
- p.Thr201Lys Single submitter ⚠
- p.Val258Leu Single submitter ⚠
- p.Val63Met Single submitter ⚠