ASCC2 — 110 ClinVar variants
All ClinVar germline ASCC2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 106 flagged for review →
4 Likely benign · 106 Uncertain significance
Full ASCC2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 106
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 64
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ASCC2 p.Ala26Val Uncertain significance Single submitter
- ASCC2 p.Ala414Ser Uncertain significance Single submitter
- ASCC2 p.Ala457Val Uncertain significance Single submitter
- ASCC2 p.Ala50Thr Uncertain significance Single submitter
- ASCC2 p.Ala735Val Uncertain significance Single submitter
- ASCC2 p.Ala738Gly Uncertain significance Single submitter
- ASCC2 p.Arg129His Uncertain significance Single submitter
- ASCC2 p.Arg586His Uncertain significance Single submitter
- ASCC2 p.Arg586Leu Uncertain significance Single submitter
- ASCC2 p.Arg58His Uncertain significance Single submitter
- ASCC2 p.Arg639His Uncertain significance Single submitter
- ASCC2 p.Arg715Gln Uncertain significance Single submitter
- ASCC2 p.Arg727Cys Uncertain significance Single submitter
- ASCC2 p.Arg727Pro Uncertain significance Single submitter
- ASCC2 p.Arg748His Uncertain significance Single submitter
- ASCC2 p.Asn172Asp Uncertain significance Single submitter
- ASCC2 p.Asn220Asp Uncertain significance Single submitter
- ASCC2 p.Asn446Ile Uncertain significance Single submitter
- ASCC2 p.Asp103Asn Uncertain significance Single submitter
- ASCC2 p.Asp274Asn Uncertain significance Single submitter
- ASCC2 p.Asp307Asn Uncertain significance Single submitter
- ASCC2 p.Asp407Ala Uncertain significance Single submitter
- ASCC2 p.Asp617Glu Uncertain significance Single submitter
- ASCC2 p.Asp621His Uncertain significance Single submitter
- ASCC2 p.Cys490Ser Uncertain significance Single submitter
- ASCC2 p.Gln31Arg Uncertain significance Single submitter
- ASCC2 p.Glu289Lys Uncertain significance Single submitter
- ASCC2 p.Glu348Lys Uncertain significance Single submitter
- ASCC2 p.Glu404Lys Uncertain significance Single submitter
- ASCC2 p.Glu421Lys Uncertain significance Single submitter
- ASCC2 p.Glu445Gly Uncertain significance Single submitter
- ASCC2 p.Glu567Lys Uncertain significance Single submitter
- ASCC2 p.Glu85Lys Uncertain significance Single submitter
- ASCC2 p.Gly105Glu Uncertain significance Single submitter
- ASCC2 p.Gly306Val Uncertain significance Single submitter
- ASCC2 p.Gly561Asp Uncertain significance Single submitter
- ASCC2 p.Gly561Ser Uncertain significance Single submitter
- ASCC2 p.Gly712Ser Uncertain significance Single submitter
- ASCC2 p.Ile637Phe Uncertain significance Single submitter
- ASCC2 p.Leu247Val Uncertain significance Single submitter
- ASCC2 p.Leu249Val Uncertain significance Single submitter
- ASCC2 p.Leu358Pro Uncertain significance Single submitter
- ASCC2 p.Leu380Pro Uncertain significance Single submitter
- ASCC2 p.Leu4Gln Uncertain significance Single submitter
- ASCC2 p.Lys137Arg Uncertain significance Single submitter
- ASCC2 p.Lys45Glu Uncertain significance Single submitter
- ASCC2 p.Lys577Arg Uncertain significance Single submitter
- ASCC2 p.Lys674Gln Uncertain significance Single submitter
- ASCC2 p.Met237Ile Uncertain significance Single submitter
- ASCC2 p.Met463Ile Uncertain significance Single submitter
- ASCC2 p.Phe37Val Uncertain significance Single submitter
- ASCC2 p.Phe83Ser Uncertain significance Single submitter
- ASCC2 p.Pro682Arg Uncertain significance Single submitter
- ASCC2 p.Pro714Ala Uncertain significance Single submitter
- ASCC2 p.Ser447Leu Uncertain significance Single submitter
- ASCC2 p.Ser604Arg Uncertain significance Single submitter
- ASCC2 p.Ser713Thr Uncertain significance Single submitter
- ASCC2 p.Ser93Phe Uncertain significance Single submitter
- ASCC2 p.Thr200Ala Uncertain significance Single submitter
- ASCC2 p.Trp257Gly Uncertain significance Single submitter
- ASCC2 p.Tyr97His Uncertain significance Single submitter
- ASCC2 p.Val406Met Uncertain significance Single submitter
- ASCC2 p.Val594Leu Uncertain significance Single submitter
- ASCC2 p.Val625Met Uncertain significance Single submitter
Predictors split 42
The independent predictors disagree with each other — read with care.
- ASCC2 p.Ala258Val Uncertain significance Single submitter
- ASCC2 p.Ala732Asp Uncertain significance Single submitter
- ASCC2 p.Arg121Gln Uncertain significance Single submitter
- ASCC2 p.Arg362Ser Uncertain significance Single submitter
- ASCC2 p.Arg365Trp Uncertain significance Single submitter
- ASCC2 p.Arg509Trp Uncertain significance Single submitter
- ASCC2 p.Arg519Cys Uncertain significance Single submitter
- ASCC2 p.Arg519His Uncertain significance Single submitter
- ASCC2 p.Arg536Cys Uncertain significance Single submitter
- ASCC2 p.Arg557Trp Uncertain significance Single submitter
- ASCC2 p.Arg565Gly Uncertain significance Single submitter
- ASCC2 p.Arg639Leu Uncertain significance Single submitter
- ASCC2 p.Arg639Ser Uncertain significance Single submitter
- ASCC2 p.Arg693His Uncertain significance Single submitter
- ASCC2 p.Arg721His Uncertain significance Single submitter
- ASCC2 p.Arg742Gln Uncertain significance Single submitter
- ASCC2 p.Asn520Ile Uncertain significance Single submitter
- ASCC2 p.Asp236Gly Uncertain significance Single submitter
- ASCC2 p.Asp481Tyr Uncertain significance Single submitter
- ASCC2 p.Asp518Glu Uncertain significance Single submitter
- ASCC2 p.Asp667Asn Uncertain significance Single submitter
- ASCC2 p.Asp67Asn Uncertain significance Single submitter
- ASCC2 p.Glu670Lys Uncertain significance Single submitter
- ASCC2 p.Glu726Gly Uncertain significance Single submitter
- ASCC2 p.Gly216Trp Uncertain significance Single submitter
- ASCC2 p.Gly712Cys Uncertain significance Single submitter
- ASCC2 p.Ile82Thr Uncertain significance Single submitter
- ASCC2 p.Leu370Phe Uncertain significance Single submitter
- ASCC2 p.Lys243Asn Uncertain significance Single submitter
- ASCC2 p.Met290Thr Uncertain significance Single submitter
- ASCC2 p.Phe205Leu Uncertain significance Single submitter
- ASCC2 p.Pro288Ala Uncertain significance Single submitter
- ASCC2 p.Pro529Ser Uncertain significance Single submitter
- ASCC2 p.Pro756Ala Uncertain significance Single submitter
- ASCC2 p.Ser338Thr Uncertain significance Single submitter
- ASCC2 p.Ser378Cys Uncertain significance Single submitter
- ASCC2 p.Ser378Gly Uncertain significance Single submitter
- ASCC2 p.Thr431Met Uncertain significance Single submitter
- ASCC2 p.Thr433Ile Uncertain significance Single submitter
- ASCC2 p.Thr643Ile Uncertain significance Single submitter
- ASCC2 p.Tyr496Cys Uncertain significance Single submitter
- ASCC2 p.Val592Met Uncertain significance Single submitter
All ASCC2 variants
Likely benign 4
- p.Arg703= Single submitter
- p.Asn520Ser Single submitter
- p.Lys562Arg Single submitter
- p.Thr564Ala Single submitter
Uncertain significance 106
- p.Ala258Val Single submitter ⚠
- p.Ala26Val Single submitter ⚠
- p.Ala414Ser Single submitter ⚠
- p.Ala457Val Single submitter ⚠
- p.Ala50Thr Single submitter ⚠
- p.Ala732Asp Single submitter ⚠
- p.Ala735Val Single submitter ⚠
- p.Ala738Gly Single submitter ⚠
- p.Arg121Gln Single submitter ⚠
- p.Arg129His Single submitter ⚠
- p.Arg362Ser Single submitter ⚠
- p.Arg365Trp Single submitter ⚠
- p.Arg509Trp Single submitter ⚠
- p.Arg519Cys Single submitter ⚠
- p.Arg519His Single submitter ⚠
- p.Arg536Cys Single submitter ⚠
- p.Arg557Trp Single submitter ⚠
- p.Arg565Gly Single submitter ⚠
- p.Arg586His Single submitter ⚠
- p.Arg586Leu Single submitter ⚠
- p.Arg58His Single submitter ⚠
- p.Arg639His Single submitter ⚠
- p.Arg639Leu Single submitter ⚠
- p.Arg639Ser Single submitter ⚠
- p.Arg693His Single submitter ⚠
- p.Arg715Gln Single submitter ⚠
- p.Arg721His Single submitter ⚠
- p.Arg727Cys Single submitter ⚠
- p.Arg727Pro Single submitter ⚠
- p.Arg742Gln Single submitter ⚠
- p.Arg748His Single submitter ⚠
- p.Asn172Asp Single submitter ⚠
- p.Asn220Asp Single submitter ⚠
- p.Asn446Ile Single submitter ⚠
- p.Asn520Ile Single submitter ⚠
- p.Asp103Asn Single submitter ⚠
- p.Asp236Gly Single submitter ⚠
- p.Asp274Asn Single submitter ⚠
- p.Asp307Asn Single submitter ⚠
- p.Asp407Ala Single submitter ⚠
- p.Asp481Tyr Single submitter ⚠
- p.Asp518Glu Single submitter ⚠
- p.Asp617Glu Single submitter ⚠
- p.Asp621His Single submitter ⚠
- p.Asp667Asn Single submitter ⚠
- p.Asp67Asn Single submitter ⚠
- p.Cys490Ser Single submitter ⚠
- p.Gln31Arg Single submitter ⚠
- p.Glu289Lys Single submitter ⚠
- p.Glu348Lys Single submitter ⚠
- p.Glu404Lys Single submitter ⚠
- p.Glu421Lys Single submitter ⚠
- p.Glu445Gly Single submitter ⚠
- p.Glu567Lys Single submitter ⚠
- p.Glu670Lys Single submitter ⚠
- p.Glu726Gly Single submitter ⚠
- p.Glu85Lys Single submitter ⚠
- p.Gly105Glu Single submitter ⚠
- p.Gly216Trp Single submitter ⚠
- p.Gly306Val Single submitter ⚠
- p.Gly561Asp Single submitter ⚠
- p.Gly561Ser Single submitter ⚠
- p.Gly712Cys Single submitter ⚠
- p.Gly712Ser Single submitter ⚠
- p.Ile637Phe Single submitter ⚠
- p.Ile82Thr Single submitter ⚠
- p.Leu247Val Single submitter ⚠
- p.Leu249Val Single submitter ⚠
- p.Leu358Pro Single submitter ⚠
- p.Leu370Phe Single submitter ⚠
- p.Leu380Pro Single submitter ⚠
- p.Leu4Gln Single submitter ⚠
- p.Lys137Arg Single submitter ⚠
- p.Lys243Asn Single submitter ⚠
- p.Lys45Glu Single submitter ⚠
- p.Lys577Arg Single submitter ⚠
- p.Lys674Gln Single submitter ⚠
- p.Met237Ile Single submitter ⚠
- p.Met290Thr Single submitter ⚠
- p.Met463Ile Single submitter ⚠
- p.Phe205Leu Single submitter ⚠
- p.Phe37Val Single submitter ⚠
- p.Phe83Ser Single submitter ⚠
- p.Pro288Ala Single submitter ⚠
- p.Pro529Ser Single submitter ⚠
- p.Pro682Arg Single submitter ⚠
- p.Pro714Ala Single submitter ⚠
- p.Pro756Ala Single submitter ⚠
- p.Ser338Thr Single submitter ⚠
- p.Ser378Cys Single submitter ⚠
- p.Ser378Gly Single submitter ⚠
- p.Ser447Leu Single submitter ⚠
- p.Ser604Arg Single submitter ⚠
- p.Ser713Thr Single submitter ⚠
- p.Ser93Phe Single submitter ⚠
- p.Thr200Ala Single submitter ⚠
- p.Thr431Met Single submitter ⚠
- p.Thr433Ile Single submitter ⚠
- p.Thr643Ile Single submitter ⚠
- p.Trp257Gly Single submitter ⚠
- p.Tyr496Cys Single submitter ⚠
- p.Tyr97His Single submitter ⚠
- p.Val406Met Single submitter ⚠
- p.Val592Met Single submitter ⚠
- p.Val594Leu Single submitter ⚠
- p.Val625Met Single submitter ⚠