ASCL2 — 38 ClinVar variants
All ClinVar germline ASCL2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 38 flagged for review →
38 Uncertain significance
Full ASCL2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 38
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ASCL2 p.Ala111Val Uncertain significance Single submitter
- ASCL2 p.Ala124Gly Uncertain significance Single submitter
- ASCL2 p.Ala21Thr Uncertain significance Single submitter
- ASCL2 p.Ala43Ser Uncertain significance Single submitter
- ASCL2 p.Ala49Thr Uncertain significance Single submitter
- ASCL2 p.Ala95Gly Uncertain significance Single submitter
- ASCL2 p.Arg100Ser Uncertain significance Single submitter
- ASCL2 p.Arg23Gln Uncertain significance Single submitter
- ASCL2 p.Asn56Ser Uncertain significance Single submitter
- ASCL2 p.Asp185Glu Uncertain significance Single submitter
- ASCL2 p.Glu157Gly Uncertain significance Single submitter
- ASCL2 p.Gly192Cys Uncertain significance Single submitter
- ASCL2 p.Gly46Ala Uncertain significance Single submitter
- ASCL2 p.Pro11Ser Uncertain significance Single submitter
- ASCL2 p.Pro11Thr Uncertain significance Single submitter
- ASCL2 p.Pro133Gln Uncertain significance Single submitter
- ASCL2 p.Pro138Leu Uncertain significance Single submitter
- ASCL2 p.Pro143Leu Uncertain significance Single submitter
- ASCL2 p.Pro17Thr Uncertain significance Single submitter
- ASCL2 p.Pro26Arg Uncertain significance Single submitter
- ASCL2 p.Pro78Ser Uncertain significance Single submitter
- ASCL2 p.Pro7Ser Uncertain significance Single submitter
- ASCL2 p.Ser144Phe Uncertain significance Single submitter
- ASCL2 p.Ser188Arg Uncertain significance Single submitter
- ASCL2 p.Ser35Arg Uncertain significance Single submitter
- ASCL2 p.Thr45Ile Uncertain significance Single submitter
- ASCL2 p.Val18Ile Uncertain significance Single submitter
- ASCL2 p.Val63Met Uncertain significance Single submitter
- ASCL2 p.Val89Leu Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- ASCL2 p.Ala50Gly Uncertain significance Single submitter
- ASCL2 p.Gln103Glu Uncertain significance Single submitter
- ASCL2 p.Glu180Gly Uncertain significance Single submitter
- ASCL2 p.His76Gln Uncertain significance Single submitter
- ASCL2 p.His79Gln Uncertain significance Single submitter
- ASCL2 p.Ser170Asn Uncertain significance Single submitter
- ASCL2 p.Ser170Cys Uncertain significance Single submitter
- ASCL2 p.Ser170Ile Uncertain significance Single submitter
- ASCL2 p.Trp189Cys Uncertain significance Single submitter
All ASCL2 variants
Uncertain significance 38
- p.Ala111Val Single submitter ⚠
- p.Ala124Gly Single submitter ⚠
- p.Ala21Thr Single submitter ⚠
- p.Ala43Ser Single submitter ⚠
- p.Ala49Thr Single submitter ⚠
- p.Ala50Gly Single submitter ⚠
- p.Ala95Gly Single submitter ⚠
- p.Arg100Ser Single submitter ⚠
- p.Arg23Gln Single submitter ⚠
- p.Asn56Ser Single submitter ⚠
- p.Asp185Glu Single submitter ⚠
- p.Gln103Glu Single submitter ⚠
- p.Glu157Gly Single submitter ⚠
- p.Glu180Gly Single submitter ⚠
- p.Gly192Cys Single submitter ⚠
- p.Gly46Ala Single submitter ⚠
- p.His76Gln Single submitter ⚠
- p.His79Gln Single submitter ⚠
- p.Pro11Ser Single submitter ⚠
- p.Pro11Thr Single submitter ⚠
- p.Pro133Gln Single submitter ⚠
- p.Pro138Leu Single submitter ⚠
- p.Pro143Leu Single submitter ⚠
- p.Pro17Thr Single submitter ⚠
- p.Pro26Arg Single submitter ⚠
- p.Pro78Ser Single submitter ⚠
- p.Pro7Ser Single submitter ⚠
- p.Ser144Phe Single submitter ⚠
- p.Ser170Asn Single submitter ⚠
- p.Ser170Cys Single submitter ⚠
- p.Ser170Ile Single submitter ⚠
- p.Ser188Arg Single submitter ⚠
- p.Ser35Arg Single submitter ⚠
- p.Thr45Ile Single submitter ⚠
- p.Trp189Cys Single submitter ⚠
- p.Val18Ile Single submitter ⚠
- p.Val63Met Single submitter ⚠
- p.Val89Leu Single submitter ⚠