ASF1A — 16 ClinVar variants
All ClinVar germline ASF1A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 15 flagged for review →
1 Likely benign · 15 Uncertain significance
Full ASF1A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 15
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ASF1A p.Ala182Val Uncertain significance Single submitter
- ASF1A p.Asp162Gly Uncertain significance Single submitter
- ASF1A p.Gln171Arg Uncertain significance Single submitter
- ASF1A p.Gly185Glu Uncertain significance Single submitter
- ASF1A p.His200Pro Uncertain significance Single submitter
- ASF1A p.Leu174Val Uncertain significance Single submitter
- ASF1A p.Pro144Ser Uncertain significance Single submitter
- ASF1A p.Ser16Cys Uncertain significance Single submitter
- ASF1A p.Val195Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- ASF1A p.Ala67Ser Uncertain significance Single submitter
- ASF1A p.Asn8Ser Uncertain significance Single submitter
- ASF1A p.Glu29Asp Uncertain significance Single submitter
- ASF1A p.Leu122Phe Uncertain significance Single submitter
- ASF1A p.Ser166Asn Uncertain significance Single submitter
- ASF1A p.Thr157Ile Uncertain significance Single submitter
All ASF1A variants
Likely benign 1
- p.Thr118= Single submitter
Uncertain significance 15
- p.Ala182Val Single submitter ⚠
- p.Ala67Ser Single submitter ⚠
- p.Asn8Ser Single submitter ⚠
- p.Asp162Gly Single submitter ⚠
- p.Gln171Arg Single submitter ⚠
- p.Glu29Asp Single submitter ⚠
- p.Gly185Glu Single submitter ⚠
- p.His200Pro Single submitter ⚠
- p.Leu122Phe Single submitter ⚠
- p.Leu174Val Single submitter ⚠
- p.Pro144Ser Single submitter ⚠
- p.Ser166Asn Single submitter ⚠
- p.Ser16Cys Single submitter ⚠
- p.Thr157Ile Single submitter ⚠
- p.Val195Ile Single submitter ⚠