ASF1B — 36 ClinVar variants
All ClinVar germline ASF1B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
1 Likely benign · 35 Uncertain significance
Full ASF1B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ASF1B p.Ala76Thr Uncertain significance Single submitter
- ASF1B p.Arg137Gln Uncertain significance Single submitter
- ASF1B p.Arg145Leu Uncertain significance Single submitter
- ASF1B p.Arg145Trp Uncertain significance Single submitter
- ASF1B p.Arg23Leu Uncertain significance Single submitter
- ASF1B p.Gly110Ser Uncertain significance Single submitter
- ASF1B p.Gly46Asp Uncertain significance Single submitter
- ASF1B p.Gly63Ser Uncertain significance Single submitter
- ASF1B p.His19Gln Uncertain significance Single submitter
- ASF1B p.His19Tyr Uncertain significance Single submitter
- ASF1B p.Ile202Val Uncertain significance Single submitter
- ASF1B p.Lys3Arg Uncertain significance Single submitter
- ASF1B p.Met71Thr Uncertain significance Single submitter
- ASF1B p.Pro144Ser Uncertain significance Single submitter
- ASF1B p.Ser20Thr Uncertain significance Single submitter
- ASF1B p.Thr100Ala Uncertain significance Single submitter
- ASF1B p.Val65Met Uncertain significance Single submitter
- ASF1B p.Val6Met Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- ASF1B p.Arg123Cys Uncertain significance Single submitter
- ASF1B p.Arg123His Uncertain significance Single submitter
- ASF1B p.Asp154Asn Uncertain significance Single submitter
- ASF1B p.Asp154Gly Uncertain significance Single submitter
- ASF1B p.Asp158Val Uncertain significance Single submitter
- ASF1B p.Asp36Asn Uncertain significance Single submitter
- ASF1B p.Asp77Asn Uncertain significance Single submitter
- ASF1B p.Glu51Asp Uncertain significance Single submitter
- ASF1B p.Ile84Leu Uncertain significance Single submitter
- ASF1B p.Leu176Phe Uncertain significance Single submitter
- ASF1B p.Leu83Val Uncertain significance Single submitter
- ASF1B p.Pro126Leu Uncertain significance Single submitter
- ASF1B p.Pro130Ala Uncertain significance Single submitter
- ASF1B p.Ser5Leu Uncertain significance Single submitter
- ASF1B p.Val113Ile Uncertain significance Single submitter
- ASF1B p.Val73Leu Uncertain significance Single submitter
- ASF1B p.Val90Met Uncertain significance Single submitter
All ASF1B variants
Likely benign 1
- p.Met157Thr Single submitter
Uncertain significance 35
- p.Ala76Thr Single submitter ⚠
- p.Arg123Cys Single submitter ⚠
- p.Arg123His Single submitter ⚠
- p.Arg137Gln Single submitter ⚠
- p.Arg145Leu Single submitter ⚠
- p.Arg145Trp Single submitter ⚠
- p.Arg23Leu Single submitter ⚠
- p.Asp154Asn Single submitter ⚠
- p.Asp154Gly Single submitter ⚠
- p.Asp158Val Single submitter ⚠
- p.Asp36Asn Single submitter ⚠
- p.Asp77Asn Single submitter ⚠
- p.Glu51Asp Single submitter ⚠
- p.Gly110Ser Single submitter ⚠
- p.Gly46Asp Single submitter ⚠
- p.Gly63Ser Single submitter ⚠
- p.His19Gln Single submitter ⚠
- p.His19Tyr Single submitter ⚠
- p.Ile202Val Single submitter ⚠
- p.Ile84Leu Single submitter ⚠
- p.Leu176Phe Single submitter ⚠
- p.Leu83Val Single submitter ⚠
- p.Lys3Arg Single submitter ⚠
- p.Met71Thr Single submitter ⚠
- p.Pro126Leu Single submitter ⚠
- p.Pro130Ala Single submitter ⚠
- p.Pro144Ser Single submitter ⚠
- p.Ser20Thr Single submitter ⚠
- p.Ser5Leu Single submitter ⚠
- p.Thr100Ala Single submitter ⚠
- p.Val113Ile Single submitter ⚠
- p.Val65Met Single submitter ⚠
- p.Val6Met Single submitter ⚠
- p.Val73Leu Single submitter ⚠
- p.Val90Met Single submitter ⚠