ASGR1 — 40 ClinVar variants
All ClinVar germline ASGR1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
2 Likely benign · 38 Uncertain significance
Full ASGR1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ASGR1 p.Asp186Glu Uncertain significance Single submitter
- ASGR1 p.Asp216Ala Uncertain significance Single submitter
- ASGR1 p.Asp243Gly Uncertain significance Single submitter
- ASGR1 p.Asp254Glu Uncertain significance Single submitter
- ASGR1 p.Cys269Phe Uncertain significance Single submitter
- ASGR1 p.Gln112Lys Uncertain significance Single submitter
- ASGR1 p.Gln113Leu Uncertain significance Single submitter
- ASGR1 p.Gln129Arg Uncertain significance Single submitter
- ASGR1 p.Gln145Arg Uncertain significance Single submitter
- ASGR1 p.Gln6Glu Uncertain significance Single submitter
- ASGR1 p.Gly146Arg Uncertain significance Single submitter
- ASGR1 p.Gly24Ala Uncertain significance Single submitter
- ASGR1 p.His126Leu Uncertain significance Single submitter
- ASGR1 p.His203Asn Uncertain significance Single submitter
- ASGR1 p.Ile59Met Uncertain significance Single submitter
- ASGR1 p.Lys103Asn Uncertain significance Single submitter
- ASGR1 p.Pro241Arg Uncertain significance Single submitter
- ASGR1 p.Pro28Ser Uncertain significance Single submitter
- ASGR1 p.Ser104Leu Uncertain significance Single submitter
- ASGR1 p.Thr227Ser Uncertain significance Single submitter
- ASGR1 p.Thr279Ala Uncertain significance Single submitter
- ASGR1 p.Val156Leu Uncertain significance Single submitter
- ASGR1 p.Val192Ile Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- ASGR1 p.Arg183Gln Likely benign Single submitter
- ASGR1 p.Arg183Gly Uncertain significance Single submitter
- ASGR1 p.Arg274Leu Uncertain significance Single submitter
- ASGR1 p.Asp133Val Uncertain significance Single submitter
- ASGR1 p.Asp243Tyr Uncertain significance Single submitter
- ASGR1 p.Glu230Lys Uncertain significance Single submitter
- ASGR1 p.Gly250Arg Uncertain significance Single submitter
- ASGR1 p.His161Gln Uncertain significance Single submitter
- ASGR1 p.Leu290Phe Uncertain significance Single submitter
- ASGR1 p.Leu91Phe Uncertain significance Single submitter
- ASGR1 p.Phe130Leu Uncertain significance Single submitter
- ASGR1 p.Pro155Ser Uncertain significance Single submitter
- ASGR1 p.Ser121Tyr Uncertain significance Single submitter
- ASGR1 p.Ser194Pro Uncertain significance Single submitter
- ASGR1 p.Ser45Cys Uncertain significance Single submitter
- ASGR1 p.Ser64Tyr Uncertain significance Single submitter
All ASGR1 variants
Likely benign 2
- p.Arg183Gln Single submitter ⚠
- p.Ile205Met Single submitter
Uncertain significance 38
- p.Arg183Gly Single submitter ⚠
- p.Arg274Leu Single submitter ⚠
- p.Asp133Val Single submitter ⚠
- p.Asp186Glu Single submitter ⚠
- p.Asp216Ala Single submitter ⚠
- p.Asp243Gly Single submitter ⚠
- p.Asp243Tyr Single submitter ⚠
- p.Asp254Glu Single submitter ⚠
- p.Cys269Phe Single submitter ⚠
- p.Gln112Lys Single submitter ⚠
- p.Gln113Leu Single submitter ⚠
- p.Gln129Arg Single submitter ⚠
- p.Gln145Arg Single submitter ⚠
- p.Gln6Glu Single submitter ⚠
- p.Glu230Lys Single submitter ⚠
- p.Gly146Arg Single submitter ⚠
- p.Gly24Ala Single submitter ⚠
- p.Gly250Arg Single submitter ⚠
- p.His126Leu Single submitter ⚠
- p.His161Gln Single submitter ⚠
- p.His203Asn Single submitter ⚠
- p.Ile59Met Single submitter ⚠
- p.Leu290Phe Single submitter ⚠
- p.Leu91Phe Single submitter ⚠
- p.Lys103Asn Single submitter ⚠
- p.Phe130Leu Single submitter ⚠
- p.Pro155Ser Single submitter ⚠
- p.Pro241Arg Single submitter ⚠
- p.Pro28Ser Single submitter ⚠
- p.Ser104Leu Single submitter ⚠
- p.Ser121Tyr Single submitter ⚠
- p.Ser194Pro Single submitter ⚠
- p.Ser45Cys Single submitter ⚠
- p.Ser64Tyr Single submitter ⚠
- p.Thr227Ser Single submitter ⚠
- p.Thr279Ala Single submitter ⚠
- p.Val156Leu Single submitter ⚠
- p.Val192Ile Single submitter ⚠