ASGR2 — 47 ClinVar variants
All ClinVar germline ASGR2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
2 Benign · 4 Likely benign · 41 Uncertain significance
Full ASGR2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ASGR2 c.241+11C>A Uncertain significance Single submitter
- ASGR2 p.Ala108Thr Uncertain significance Single submitter
- ASGR2 p.Arg169Lys Uncertain significance Single submitter
- ASGR2 p.Arg248Lys Uncertain significance Single submitter
- ASGR2 p.Asn227Ser Uncertain significance Single submitter
- ASGR2 p.Gln168Arg Uncertain significance Single submitter
- ASGR2 p.Gln9Arg Uncertain significance Single submitter
- ASGR2 p.Glu266Lys Uncertain significance Single submitter
- ASGR2 p.Ile120Met Uncertain significance Single submitter
- ASGR2 p.Leu61Val Uncertain significance Single submitter
- ASGR2 p.Phe5Cys Uncertain significance Single submitter
- ASGR2 p.Pro38Thr Uncertain significance Single submitter
- ASGR2 p.Thr302Pro Uncertain significance Single submitter
- ASGR2 p.Val116Met Uncertain significance Single submitter
- ASGR2 p.Val150Met Uncertain significance Single submitter
- ASGR2 p.Val177Met Uncertain significance Single submitter
- ASGR2 p.Val72Glu Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- ASGR2 p.Ala108Pro Uncertain significance Single submitter
- ASGR2 p.Arg153Cys Uncertain significance Single submitter
- ASGR2 p.Arg292Cys Uncertain significance Single submitter
- ASGR2 p.Arg52Cys Uncertain significance Single submitter
- ASGR2 p.Arg52His Uncertain significance Single submitter
- ASGR2 p.Arg89Trp Uncertain significance Single submitter
- ASGR2 p.Asp234Asn Uncertain significance Single submitter
- ASGR2 p.Asp260Gly Uncertain significance Single submitter
- ASGR2 p.Asp279Gly Uncertain significance Single submitter
- ASGR2 p.Asp284Gly Uncertain significance Single submitter
- ASGR2 p.Gln180His Uncertain significance Single submitter
- ASGR2 p.Glu197Lys Uncertain significance Single submitter
- ASGR2 p.Glu271Gln Uncertain significance Single submitter
- ASGR2 p.Glu271Lys Uncertain significance Single submitter
- ASGR2 p.Gly237Arg Uncertain significance Single submitter
- ASGR2 p.Gly264Arg Uncertain significance Single submitter
- ASGR2 p.Leu64Pro Uncertain significance Single submitter
- ASGR2 p.Pro278Leu Uncertain significance Single submitter
- ASGR2 p.Pro48Leu Uncertain significance Single submitter
- ASGR2 p.Ser100Leu Uncertain significance Single submitter
- ASGR2 p.Ser96Gly Uncertain significance Single submitter
- ASGR2 p.Thr104Met Likely benign Single submitter
- ASGR2 p.Thr223Met Uncertain significance Single submitter
- ASGR2 p.Thr228Ile Uncertain significance Single submitter
- ASGR2 p.Val256Gly Uncertain significance Single submitter
All ASGR2 variants
Likely benign 4
- p.Asn37Asp Single submitter
- p.Gly124Glu Single submitter
- p.Thr104Met Single submitter ⚠
- p.Val155Leu Single submitter
Uncertain significance 41
- c.241+11C>A Single submitter ⚠
- p.Ala108Pro Single submitter ⚠
- p.Ala108Thr Single submitter ⚠
- p.Arg153Cys Single submitter ⚠
- p.Arg169Lys Single submitter ⚠
- p.Arg248Lys Single submitter ⚠
- p.Arg292Cys Single submitter ⚠
- p.Arg52Cys Single submitter ⚠
- p.Arg52His Single submitter ⚠
- p.Arg89Trp Single submitter ⚠
- p.Asn227Ser Single submitter ⚠
- p.Asp234Asn Single submitter ⚠
- p.Asp260Gly Single submitter ⚠
- p.Asp279Gly Single submitter ⚠
- p.Asp284Gly Single submitter ⚠
- p.Gln168Arg Single submitter ⚠
- p.Gln180His Single submitter ⚠
- p.Gln9Arg Single submitter ⚠
- p.Glu197Lys Single submitter ⚠
- p.Glu266Lys Single submitter ⚠
- p.Glu271Gln Single submitter ⚠
- p.Glu271Lys Single submitter ⚠
- p.Gly237Arg Single submitter ⚠
- p.Gly264Arg Single submitter ⚠
- p.Ile120Met Single submitter ⚠
- p.Leu61Val Single submitter ⚠
- p.Leu64Pro Single submitter ⚠
- p.Phe5Cys Single submitter ⚠
- p.Pro278Leu Single submitter ⚠
- p.Pro38Thr Single submitter ⚠
- p.Pro48Leu Single submitter ⚠
- p.Ser100Leu Single submitter ⚠
- p.Ser96Gly Single submitter ⚠
- p.Thr223Met Single submitter ⚠
- p.Thr228Ile Single submitter ⚠
- p.Thr302Pro Single submitter ⚠
- p.Val116Met Single submitter ⚠
- p.Val150Met Single submitter ⚠
- p.Val177Met Single submitter ⚠
- p.Val256Gly Single submitter ⚠
- p.Val72Glu Single submitter ⚠