ASIC3 — 123 ClinVar variants
All ClinVar germline ASIC3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 103 flagged for review →
2 Benign · 14 Likely benign · 107 Uncertain significance
Full ASIC3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 103
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 51
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ASIC3 p.Ala120Thr Uncertain significance Single submitter
- ASIC3 p.Ala147Val Uncertain significance Single submitter
- ASIC3 p.Ala325Thr Uncertain significance Single submitter
- ASIC3 p.Ala351Pro Uncertain significance Single submitter
- ASIC3 p.Ala365Val Uncertain significance Single submitter
- ASIC3 p.Ala394Pro Uncertain significance Single submitter
- ASIC3 p.Arg152Cys Uncertain significance Single submitter
- ASIC3 p.Arg182Gln Uncertain significance Single submitter
- ASIC3 p.Arg18His Uncertain significance Single submitter
- ASIC3 p.Arg238Gly Uncertain significance Single submitter
- ASIC3 p.Arg495Gly Uncertain significance Single submitter
- ASIC3 p.Arg523His Uncertain significance Single submitter
- ASIC3 p.Arg523Leu Uncertain significance Single submitter
- ASIC3 p.Arg79Gln Uncertain significance Single submitter
- ASIC3 p.Asp215Gly Uncertain significance Single submitter
- ASIC3 p.Asp251Asn Uncertain significance Single submitter
- ASIC3 p.Cys328Trp Uncertain significance Single submitter
- ASIC3 p.Cys512Phe Uncertain significance Single submitter
- ASIC3 p.Gln268Arg Uncertain significance Single submitter
- ASIC3 p.Gln345His Uncertain significance Single submitter
- ASIC3 p.Glu294Gly Uncertain significance Single submitter
- ASIC3 p.Glu9Lys Uncertain significance Single submitter
- ASIC3 p.Gly111Arg Uncertain significance Single submitter
- ASIC3 p.Gly504Asp Uncertain significance Single submitter
- ASIC3 p.Leu162Val Uncertain significance Single submitter
- ASIC3 p.Leu312Pro Uncertain significance Single submitter
- ASIC3 p.Leu527Arg Uncertain significance Single submitter
- ASIC3 p.Leu91Pro Uncertain significance Single submitter
- ASIC3 p.Lys361Gln Uncertain significance Single submitter
- ASIC3 p.Lys361Thr Uncertain significance Single submitter
- ASIC3 p.Met44Ile Uncertain significance Single submitter
- ASIC3 p.Phe70Leu Uncertain significance Single submitter
- ASIC3 p.Phe86Leu Uncertain significance Single submitter
- ASIC3 p.Pro232Leu Uncertain significance Single submitter
- ASIC3 p.Pro259Leu Uncertain significance Single submitter
- ASIC3 p.Pro289Leu Uncertain significance Single submitter
- ASIC3 p.Pro308Ala Uncertain significance Single submitter
- ASIC3 p.Pro367Ser Uncertain significance Single submitter
- ASIC3 p.Pro510Leu Uncertain significance Single submitter
- ASIC3 p.Pro87Leu Uncertain significance Single submitter
- ASIC3 p.Ser15Leu Uncertain significance Single submitter
- ASIC3 p.Ser25Leu Uncertain significance Single submitter
- ASIC3 p.Ser493Asn Uncertain significance Single submitter
- ASIC3 p.Thr201Ser Uncertain significance Single submitter
- ASIC3 p.Thr515Asn Uncertain significance Single submitter
- ASIC3 p.Trp279Cys Uncertain significance Single submitter
- ASIC3 p.Tyr150His Uncertain significance Single submitter
- ASIC3 p.Tyr347Cys Uncertain significance Single submitter
- ASIC3 p.Tyr375His Uncertain significance Single submitter
- ASIC3 p.Val339Met Uncertain significance Single submitter
- ASIC3 p.Val341Ala Uncertain significance Single submitter
Predictors split 52
The independent predictors disagree with each other — read with care.
- ASIC3 p.Ala110Ser Uncertain significance Single submitter
- ASIC3 p.Ala124Thr Uncertain significance Single submitter
- ASIC3 p.Ala193Asp Uncertain significance Single submitter
- ASIC3 p.Ala390Val Uncertain significance Single submitter
- ASIC3 p.Ala46Val Uncertain significance Single submitter
- ASIC3 p.Arg127His Benign Single submitter
- ASIC3 p.Arg127Leu Uncertain significance Single submitter
- ASIC3 p.Arg12Gln Uncertain significance Single submitter
- ASIC3 p.Arg165Cys Uncertain significance Single submitter
- ASIC3 p.Arg165His Uncertain significance Single submitter
- ASIC3 p.Arg167Cys Uncertain significance Single submitter
- ASIC3 p.Arg182Trp Uncertain significance Single submitter
- ASIC3 p.Arg326Leu Uncertain significance Single submitter
- ASIC3 p.Arg331Gly Uncertain significance Single submitter
- ASIC3 p.Arg383Trp Uncertain significance Single submitter
- ASIC3 p.Arg387Cys Uncertain significance Single submitter
- ASIC3 p.Arg391Cys Uncertain significance Single submitter
- ASIC3 p.Arg391Leu Uncertain significance Single submitter
- ASIC3 p.Arg41His Uncertain significance Single submitter
- ASIC3 p.Arg42Pro Uncertain significance Single submitter
- ASIC3 p.Arg523Cys Likely benign Single submitter
- ASIC3 p.Arg65Cys Uncertain significance Single submitter
- ASIC3 p.Arg83Gly Uncertain significance Single submitter
- ASIC3 p.Asp251Gly Uncertain significance Single submitter
- ASIC3 p.Asp356Gly Uncertain significance Single submitter
- ASIC3 p.Gln217Arg Uncertain significance Single submitter
- ASIC3 p.Gln240Glu Uncertain significance Single submitter
- ASIC3 p.Gly130Ser Uncertain significance Single submitter
- ASIC3 p.Gly137Ser Uncertain significance Single submitter
- ASIC3 p.Gly314Glu Uncertain significance Single submitter
- ASIC3 p.His108Arg Uncertain significance Single submitter
- ASIC3 p.Ile237Met Uncertain significance Single submitter
- ASIC3 p.Ile438Thr Uncertain significance Single submitter
- ASIC3 p.Leu117Pro Uncertain significance Single submitter
- ASIC3 p.Leu359Pro Uncertain significance Single submitter
- ASIC3 p.Met160Thr Uncertain significance Single submitter
- ASIC3 p.Met213Val Uncertain significance Single submitter
- ASIC3 p.Phe233Ser Uncertain significance Single submitter
- ASIC3 p.Pro104Ser Uncertain significance Single submitter
- ASIC3 p.Pro135Leu Uncertain significance Single submitter
- ASIC3 p.Ser25Ala Uncertain significance Single submitter
- ASIC3 p.Ser25Pro Uncertain significance Single submitter
- ASIC3 p.Ser305Gly Uncertain significance Single submitter
- ASIC3 p.Ser343Arg Uncertain significance Single submitter
- ASIC3 p.Ser372Arg Uncertain significance Single submitter
- ASIC3 p.Thr103Met Uncertain significance Single submitter
- ASIC3 p.Thr181Ser Uncertain significance Single submitter
- ASIC3 p.Val19Met Uncertain significance Single submitter
- ASIC3 p.Val216Met Uncertain significance Single submitter
- ASIC3 p.Val257Ala Likely benign Single submitter
- ASIC3 p.Val257Leu Uncertain significance Single submitter
- ASIC3 p.Val32Ile Uncertain significance Single submitter
All ASIC3 variants
Benign 2
- p.Pro289Ser Multiple submitters
- p.Arg127His Single submitter ⚠
Likely benign 14
- c.814-5C>A Single submitter
- c.*19C>T Single submitter
- c.*20G>A Single submitter
- p.Ala513= Single submitter
- p.Ala520Thr Single submitter
- p.Arg523Cys Single submitter ⚠
- p.Asp281= Single submitter
- p.Leu527= Single submitter
- p.Pro308Leu Single submitter
- p.Thr311Ser Single submitter
- p.Thr4Pro Single submitter
- p.Thr515Ser Single submitter
- p.Val257Ala Single submitter ⚠
- p.Val528Ile Single submitter
Uncertain significance 107
- c.1518-4G>A Single submitter
- c.*27C>T Single submitter
- c.*3C>A Single submitter
- c.*3C>T Single submitter
- p.Ala110Ser Single submitter ⚠
- p.Ala120Thr Single submitter ⚠
- p.Ala124Thr Single submitter ⚠
- p.Ala147Val Single submitter ⚠
- p.Ala193Asp Single submitter ⚠
- p.Ala325Thr Single submitter ⚠
- p.Ala351Pro Single submitter ⚠
- p.Ala365Val Single submitter ⚠
- p.Ala390Val Single submitter ⚠
- p.Ala394Pro Single submitter ⚠
- p.Ala46Val Single submitter ⚠
- p.Ala520= Single submitter
- p.Arg127Leu Single submitter ⚠
- p.Arg12Gln Single submitter ⚠
- p.Arg152Cys Single submitter ⚠
- p.Arg165Cys Single submitter ⚠
- p.Arg165His Single submitter ⚠
- p.Arg167Cys Single submitter ⚠
- p.Arg182Gln Single submitter ⚠
- p.Arg182Trp Single submitter ⚠
- p.Arg18His Single submitter ⚠
- p.Arg238Gly Single submitter ⚠
- p.Arg326Leu Single submitter ⚠
- p.Arg331Gly Single submitter ⚠
- p.Arg383Trp Single submitter ⚠
- p.Arg387Cys Single submitter ⚠
- p.Arg391Cys Single submitter ⚠
- p.Arg391Leu Single submitter ⚠
- p.Arg41His Single submitter ⚠
- p.Arg42Pro Single submitter ⚠
- p.Arg495Gly Single submitter ⚠
- p.Arg523His Single submitter ⚠
- p.Arg523Leu Single submitter ⚠
- p.Arg65Cys Single submitter ⚠
- p.Arg79Gln Single submitter ⚠
- p.Arg79Ter Single submitter
- p.Arg83Gly Single submitter ⚠
- p.Asp215Gly Single submitter ⚠
- p.Asp251Asn Single submitter ⚠
- p.Asp251Gly Single submitter ⚠
- p.Asp356Gly Single submitter ⚠
- p.Cys328Trp Single submitter ⚠
- p.Cys512Phe Single submitter ⚠
- p.Gln217Arg Single submitter ⚠
- p.Gln240Glu Single submitter ⚠
- p.Gln268Arg Single submitter ⚠
- p.Gln345His Single submitter ⚠
- p.Glu294Gly Single submitter ⚠
- p.Glu9Lys Single submitter ⚠
- p.Gly111Arg Single submitter ⚠
- p.Gly130Ser Single submitter ⚠
- p.Gly137Ser Single submitter ⚠
- p.Gly314Glu Single submitter ⚠
- p.Gly504Asp Single submitter ⚠
- p.His108Arg Single submitter ⚠
- p.Ile237Met Single submitter ⚠
- p.Ile438Thr Single submitter ⚠
- p.Leu117Pro Single submitter ⚠
- p.Leu162Val Single submitter ⚠
- p.Leu312Pro Single submitter ⚠
- p.Leu359Pro Single submitter ⚠
- p.Leu527Arg Single submitter ⚠
- p.Leu91Pro Single submitter ⚠
- p.Lys361Gln Single submitter ⚠
- p.Lys361Thr Single submitter ⚠
- p.Met160Thr Single submitter ⚠
- p.Met213Val Single submitter ⚠
- p.Met44Ile Single submitter ⚠
- p.Phe233Ser Single submitter ⚠
- p.Phe70Leu Single submitter ⚠
- p.Phe86Leu Single submitter ⚠
- p.Pro104Ser Single submitter ⚠
- p.Pro135Leu Single submitter ⚠
- p.Pro232Leu Single submitter ⚠
- p.Pro259Leu Single submitter ⚠
- p.Pro289Leu Single submitter ⚠
- p.Pro308Ala Single submitter ⚠
- p.Pro367Ser Single submitter ⚠
- p.Pro510Leu Single submitter ⚠
- p.Pro87Leu Single submitter ⚠
- p.Ser15Leu Single submitter ⚠
- p.Ser25Ala Single submitter ⚠
- p.Ser25Leu Single submitter ⚠
- p.Ser25Pro Single submitter ⚠
- p.Ser305Gly Single submitter ⚠
- p.Ser343Arg Single submitter ⚠
- p.Ser372Arg Single submitter ⚠
- p.Ser493Asn Single submitter ⚠
- p.Thr103Met Single submitter ⚠
- p.Thr181Ser Single submitter ⚠
- p.Thr201Ser Single submitter ⚠
- p.Thr515Asn Single submitter ⚠
- p.Trp279Cys Single submitter ⚠
- p.Tyr150fs Single submitter
- p.Tyr150His Single submitter ⚠
- p.Tyr347Cys Single submitter ⚠
- p.Tyr375His Single submitter ⚠
- p.Val19Met Single submitter ⚠
- p.Val216Met Single submitter ⚠
- p.Val257Leu Single submitter ⚠
- p.Val32Ile Single submitter ⚠
- p.Val339Met Single submitter ⚠
- p.Val341Ala Single submitter ⚠