ASPG — 102 ClinVar variants
All ClinVar germline ASPG variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 95 flagged for review →
1 Benign · 9 Likely benign · 92 Uncertain significance
Full ASPG gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 95
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ASPG p.Ala315Val Uncertain significance Single submitter
- ASPG p.Ala544Thr Uncertain significance Single submitter
- ASPG p.Arg192Gly Uncertain significance Single submitter
- ASPG p.Arg192Trp Uncertain significance Single submitter
- ASPG p.Arg368Leu Uncertain significance Single submitter
- ASPG p.Arg68Cys Uncertain significance Single submitter
- ASPG p.Asn375His Uncertain significance Single submitter
- ASPG p.Asp413Ala Uncertain significance Single submitter
- ASPG p.Asp431Gly Uncertain significance Single submitter
- ASPG p.Cys198Ser Uncertain significance Single submitter
- ASPG p.Cys296Arg Uncertain significance Single submitter
- ASPG p.Gln177Arg Uncertain significance Single submitter
- ASPG p.Gln554Arg Uncertain significance Single submitter
- ASPG p.Glu105Gln Uncertain significance Single submitter
- ASPG p.Glu266Gln Uncertain significance Single submitter
- ASPG p.Glu448Gln Uncertain significance Single submitter
- ASPG p.Gly380Arg Uncertain significance Single submitter
- ASPG p.Gly561Ala Uncertain significance Single submitter
- ASPG p.Gly572Asp Uncertain significance Single submitter
- ASPG p.His147Tyr Uncertain significance Single submitter
- ASPG p.Ile483Met Uncertain significance Single submitter
- ASPG p.Leu205Pro Uncertain significance Single submitter
- ASPG p.Phe45Tyr Uncertain significance Single submitter
- ASPG p.Pro480Leu Uncertain significance Single submitter
- ASPG p.Pro65Leu Uncertain significance Single submitter
- ASPG p.Ser151Arg Uncertain significance Single submitter
- ASPG p.Ser425Arg Uncertain significance Single submitter
- ASPG p.Thr19Pro Uncertain significance Single submitter
- ASPG p.Thr462Ile Uncertain significance Single submitter
- ASPG p.Trp150Arg Uncertain significance Single submitter
- ASPG p.Tyr167Phe Uncertain significance Single submitter
Predictors split 64
The independent predictors disagree with each other — read with care.
- ASPG p.Ala315Gly Uncertain significance Single submitter
- ASPG p.Ala332Val Uncertain significance Single submitter
- ASPG p.Ala442Thr Uncertain significance Single submitter
- ASPG p.Ala4Thr Uncertain significance Single submitter
- ASPG p.Ala537Ser Uncertain significance Single submitter
- ASPG p.Ala53Pro Uncertain significance Single submitter
- ASPG p.Ala559Val Uncertain significance Single submitter
- ASPG p.Arg10Gly Uncertain significance Single submitter
- ASPG p.Arg154Gly Uncertain significance Single submitter
- ASPG p.Arg154His Uncertain significance Single submitter
- ASPG p.Arg182Trp Uncertain significance Single submitter
- ASPG p.Arg220Trp Uncertain significance Single submitter
- ASPG p.Arg253Gly Uncertain significance Single submitter
- ASPG p.Arg253Trp Uncertain significance Single submitter
- ASPG p.Arg289Cys Uncertain significance Single submitter
- ASPG p.Arg357Trp Uncertain significance Single submitter
- ASPG p.Arg369Trp Uncertain significance Single submitter
- ASPG p.Arg397Trp Uncertain significance Single submitter
- ASPG p.Arg443Gln Uncertain significance Single submitter
- ASPG p.Arg443Trp Uncertain significance Single submitter
- ASPG p.Arg476Gln Uncertain significance Single submitter
- ASPG p.Arg487Trp Uncertain significance Single submitter
- ASPG p.Asn295Ser Uncertain significance Single submitter
- ASPG p.Asn546Ser Uncertain significance Single submitter
- ASPG p.Asp152Asn Uncertain significance Single submitter
- ASPG p.Asp426Glu Uncertain significance Single submitter
- ASPG p.Asp459Tyr Uncertain significance Single submitter
- ASPG p.Asp513Asn Uncertain significance Single submitter
- ASPG p.Glu105Lys Likely benign Single submitter
- ASPG p.Glu288Lys Likely benign Single submitter
- ASPG p.Glu48Asp Uncertain significance Single submitter
- ASPG p.Gly239Ser Uncertain significance Single submitter
- ASPG p.Gly290Ser Uncertain significance Single submitter
- ASPG p.Gly311Asp Uncertain significance Single submitter
- ASPG p.Gly318Arg Uncertain significance Single submitter
- ASPG p.Gly467Ser Uncertain significance Single submitter
- ASPG p.Gly490Arg Uncertain significance Single submitter
- ASPG p.Gly55Ser Uncertain significance Single submitter
- ASPG p.His108Arg Uncertain significance Single submitter
- ASPG p.His298Tyr Uncertain significance Single submitter
- ASPG p.Leu218Met Uncertain significance Single submitter
- ASPG p.Leu372Met Uncertain significance Single submitter
- ASPG p.Leu377Pro Uncertain significance Single submitter
- ASPG p.Leu384Pro Uncertain significance Single submitter
- ASPG p.Leu82Val Uncertain significance Single submitter
- ASPG p.Lys135Gln Uncertain significance Single submitter
- ASPG p.Met234Lys Uncertain significance Single submitter
- ASPG p.Met88Val Uncertain significance Single submitter
- ASPG p.Phe83Ser Uncertain significance Single submitter
- ASPG p.Pro258Arg Uncertain significance Single submitter
- ASPG p.Pro277His Uncertain significance Single submitter
- ASPG p.Pro341Leu Uncertain significance Single submitter
- ASPG p.Pro567Leu Uncertain significance Single submitter
- ASPG p.Ser124Leu Uncertain significance Single submitter
- ASPG p.Thr376Met Uncertain significance Single submitter
- ASPG p.Tyr107Cys Uncertain significance Single submitter
- ASPG p.Tyr15Cys Uncertain significance Single submitter
- ASPG p.Tyr532His Uncertain significance Single submitter
- ASPG p.Val263Met Likely benign Single submitter
- ASPG p.Val319Phe Uncertain significance Single submitter
- ASPG p.Val381Ala Uncertain significance Single submitter
- ASPG p.Val460Leu Uncertain significance Single submitter
- ASPG p.Val460Met Uncertain significance Single submitter
- ASPG p.Val76Met Uncertain significance Single submitter
All ASPG variants
Benign 1
- p.Asp223= Multiple submitters
Likely benign 9
- p.Arg284Gln Single submitter
- p.Arg52Gln Single submitter
- p.Arg54His Single submitter
- p.Glu105Lys Single submitter ⚠
- p.Glu288Lys Single submitter ⚠
- p.Gly224Arg Single submitter
- p.Gly380= Single submitter
- p.Pro7Ser Single submitter
- p.Val263Met Single submitter ⚠
Uncertain significance 92
- p.Ala315Gly Single submitter ⚠
- p.Ala315Val Single submitter ⚠
- p.Ala332Val Single submitter ⚠
- p.Ala442Thr Single submitter ⚠
- p.Ala4Thr Single submitter ⚠
- p.Ala537Ser Single submitter ⚠
- p.Ala53Pro Single submitter ⚠
- p.Ala544Thr Single submitter ⚠
- p.Ala559Val Single submitter ⚠
- p.Arg10Gly Single submitter ⚠
- p.Arg154Gly Single submitter ⚠
- p.Arg154His Single submitter ⚠
- p.Arg182Trp Single submitter ⚠
- p.Arg192Gly Single submitter ⚠
- p.Arg192Trp Single submitter ⚠
- p.Arg220Trp Single submitter ⚠
- p.Arg253Gly Single submitter ⚠
- p.Arg253Trp Single submitter ⚠
- p.Arg289Cys Single submitter ⚠
- p.Arg357Trp Single submitter ⚠
- p.Arg368Leu Single submitter ⚠
- p.Arg369Trp Single submitter ⚠
- p.Arg397Trp Single submitter ⚠
- p.Arg443Gln Single submitter ⚠
- p.Arg443Trp Single submitter ⚠
- p.Arg476Gln Single submitter ⚠
- p.Arg487Trp Single submitter ⚠
- p.Arg68Cys Single submitter ⚠
- p.Asn295Ser Single submitter ⚠
- p.Asn375His Single submitter ⚠
- p.Asn546Ser Single submitter ⚠
- p.Asp152Asn Single submitter ⚠
- p.Asp413Ala Single submitter ⚠
- p.Asp426Glu Single submitter ⚠
- p.Asp431Gly Single submitter ⚠
- p.Asp459Tyr Single submitter ⚠
- p.Asp513Asn Single submitter ⚠
- p.Cys198Ser Single submitter ⚠
- p.Cys296Arg Single submitter ⚠
- p.Gln177Arg Single submitter ⚠
- p.Gln554Arg Single submitter ⚠
- p.Glu105Gln Single submitter ⚠
- p.Glu266Gln Single submitter ⚠
- p.Glu448Gln Single submitter ⚠
- p.Glu48Asp Single submitter ⚠
- p.Gly239Ser Single submitter ⚠
- p.Gly290Ser Single submitter ⚠
- p.Gly311Asp Single submitter ⚠
- p.Gly318Arg Single submitter ⚠
- p.Gly380Arg Single submitter ⚠
- p.Gly467Ser Single submitter ⚠
- p.Gly490Arg Single submitter ⚠
- p.Gly55Ser Single submitter ⚠
- p.Gly561Ala Single submitter ⚠
- p.Gly572Asp Single submitter ⚠
- p.His108Arg Single submitter ⚠
- p.His147Tyr Single submitter ⚠
- p.His298Tyr Single submitter ⚠
- p.Ile483Met Single submitter ⚠
- p.Leu205Pro Single submitter ⚠
- p.Leu218Met Single submitter ⚠
- p.Leu372Met Single submitter ⚠
- p.Leu377Pro Single submitter ⚠
- p.Leu384Pro Single submitter ⚠
- p.Leu82Val Single submitter ⚠
- p.Lys135Gln Single submitter ⚠
- p.Met234Lys Single submitter ⚠
- p.Met88Val Single submitter ⚠
- p.Phe45Tyr Single submitter ⚠
- p.Phe83Ser Single submitter ⚠
- p.Pro258Arg Single submitter ⚠
- p.Pro277His Single submitter ⚠
- p.Pro341Leu Single submitter ⚠
- p.Pro480Leu Single submitter ⚠
- p.Pro567Leu Single submitter ⚠
- p.Pro65Leu Single submitter ⚠
- p.Ser124Leu Single submitter ⚠
- p.Ser151Arg Single submitter ⚠
- p.Ser425Arg Single submitter ⚠
- p.Thr19Pro Single submitter ⚠
- p.Thr376Met Single submitter ⚠
- p.Thr462Ile Single submitter ⚠
- p.Trp150Arg Single submitter ⚠
- p.Tyr107Cys Single submitter ⚠
- p.Tyr15Cys Single submitter ⚠
- p.Tyr167Phe Single submitter ⚠
- p.Tyr532His Single submitter ⚠
- p.Val319Phe Single submitter ⚠
- p.Val381Ala Single submitter ⚠
- p.Val460Leu Single submitter ⚠
- p.Val460Met Single submitter ⚠
- p.Val76Met Single submitter ⚠