ATAD3C — 123 ClinVar variants
All ClinVar germline ATAD3C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 113 flagged for review →
1 Conflicting · 1 Benign · 11 Likely benign · 110 Uncertain significance
Full ATAD3C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 113
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 39
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ATAD3C p.Ala120Val Uncertain significance Single submitter
- ATAD3C p.Ala307Gly Uncertain significance Single submitter
- ATAD3C p.Ala307Val Uncertain significance Single submitter
- ATAD3C p.Ala91Glu Uncertain significance Single submitter
- ATAD3C p.Ala93Val Uncertain significance Single submitter
- ATAD3C p.Arg167Gln Uncertain significance Single submitter
- ATAD3C p.Arg327Trp Uncertain significance Single submitter
- ATAD3C p.Arg33Gln Uncertain significance Single submitter
- ATAD3C p.Arg395His Uncertain significance Single submitter
- ATAD3C p.Asp138Gly Uncertain significance Single submitter
- ATAD3C p.Cys279Tyr Uncertain significance Single submitter
- ATAD3C p.Gln12Arg Uncertain significance Single submitter
- ATAD3C p.Glu400Asp Uncertain significance Single submitter
- ATAD3C p.Glu400Gly Uncertain significance Single submitter
- ATAD3C p.Glu400Val Uncertain significance Single submitter
- ATAD3C p.Gly177Arg Uncertain significance Single submitter
- ATAD3C p.His280Tyr Uncertain significance Single submitter
- ATAD3C p.Ile288Val Uncertain significance Single submitter
- ATAD3C p.Ile99Val Uncertain significance Single submitter
- ATAD3C p.Lys164Arg Uncertain significance Single submitter
- ATAD3C p.Lys165Gln Uncertain significance Single submitter
- ATAD3C p.Lys326Asn Uncertain significance Single submitter
- ATAD3C p.Lys34Arg Uncertain significance Single submitter
- ATAD3C p.Lys354Asn Uncertain significance Single submitter
- ATAD3C p.Met159Ile Uncertain significance Single submitter
- ATAD3C p.Met312Thr Uncertain significance Single submitter
- ATAD3C p.Met379Ile Uncertain significance Single submitter
- ATAD3C p.Phe234Leu Uncertain significance Single submitter
- ATAD3C p.Phe298Leu Uncertain significance Single submitter
- ATAD3C p.Pro409His Uncertain significance Single submitter
- ATAD3C p.Thr15Met Uncertain significance Single submitter
- ATAD3C p.Thr265Met Uncertain significance Single submitter
- ATAD3C p.Thr45Ile Uncertain significance Single submitter
- ATAD3C p.Thr66Arg Uncertain significance Single submitter
- ATAD3C p.Thr79Ala Uncertain significance Single submitter
- ATAD3C p.Thr92Ile Uncertain significance Single submitter
- ATAD3C p.Val153Leu Uncertain significance Single submitter
- ATAD3C p.Val373Ile Uncertain significance Single submitter
- ATAD3C p.Val94Ala Uncertain significance Single submitter
Predictors split 74
The independent predictors disagree with each other — read with care.
- ATAD3C p.Ala101Thr Uncertain significance Single submitter
- ATAD3C p.Ala101Val Uncertain significance Single submitter
- ATAD3C p.Ala157Thr Uncertain significance Single submitter
- ATAD3C p.Ala240Thr Uncertain significance Single submitter
- ATAD3C p.Ala260Thr Uncertain significance Single submitter
- ATAD3C p.Ala277Thr Uncertain significance Single submitter
- ATAD3C p.Ala344Thr Uncertain significance Single submitter
- ATAD3C p.Ala356Thr Uncertain significance Single submitter
- ATAD3C p.Ala368Val Uncertain significance Single submitter
- ATAD3C p.Ala381Val Uncertain significance Single submitter
- ATAD3C p.Ala91Gly Uncertain significance Single submitter
- ATAD3C p.Arg102Trp Uncertain significance Single submitter
- ATAD3C p.Arg110Gly Uncertain significance Single submitter
- ATAD3C p.Arg114Cys Uncertain significance Single submitter
- ATAD3C p.Arg122Gln Likely benign Single submitter
- ATAD3C p.Arg122Gly Uncertain significance Single submitter
- ATAD3C p.Arg122Trp Uncertain significance Single submitter
- ATAD3C p.Arg130Gln Uncertain significance Single submitter
- ATAD3C p.Arg131Gln Uncertain significance Single submitter
- ATAD3C p.Arg135Gln Uncertain significance Single submitter
- ATAD3C p.Arg154Cys Conflicting Single submitter
- ATAD3C p.Arg167Trp Uncertain significance Single submitter
- ATAD3C p.Arg211Gln Uncertain significance Single submitter
- ATAD3C p.Arg211Trp Uncertain significance Single submitter
- ATAD3C p.Arg228Gln Uncertain significance Single submitter
- ATAD3C p.Arg228Trp Uncertain significance Single submitter
- ATAD3C p.Arg243Trp Uncertain significance Single submitter
- ATAD3C p.Arg264Cys Uncertain significance Single submitter
- ATAD3C p.Arg306Gln Uncertain significance Single submitter
- ATAD3C p.Arg308Cys Uncertain significance Single submitter
- ATAD3C p.Arg308His Uncertain significance Single submitter
- ATAD3C p.Arg33Trp Uncertain significance Single submitter
- ATAD3C p.Arg353Gln Uncertain significance Single submitter
- ATAD3C p.Arg68Gln Uncertain significance Single submitter
- ATAD3C p.Asn315Ile Uncertain significance Single submitter
- ATAD3C p.Asp285Tyr Uncertain significance Single submitter
- ATAD3C p.Asp293Gly Uncertain significance Single submitter
- ATAD3C p.Asp299Asn Uncertain significance Single submitter
- ATAD3C p.Gln35Pro Uncertain significance Single submitter
- ATAD3C p.Glu100Ala Uncertain significance Single submitter
- ATAD3C p.Glu100Gln Uncertain significance Single submitter
- ATAD3C p.Glu237Lys Uncertain significance Single submitter
- ATAD3C p.Glu252Lys Uncertain significance Single submitter
- ATAD3C p.Glu376Ala Uncertain significance Single submitter
- ATAD3C p.Glu376Lys Uncertain significance Single submitter
- ATAD3C p.Gly142Ala Uncertain significance Single submitter
- ATAD3C p.Gly180Ala Uncertain significance Single submitter
- ATAD3C p.Gly180Val Uncertain significance Single submitter
- ATAD3C p.Gly182Arg Uncertain significance Single submitter
- ATAD3C p.Gly213Asp Uncertain significance Single submitter
- ATAD3C p.Gly230Ser Uncertain significance Single submitter
- ATAD3C p.Ile288Thr Uncertain significance Single submitter
- ATAD3C p.Ile99Met Uncertain significance Single submitter
- ATAD3C p.Leu24Phe Uncertain significance Single submitter
- ATAD3C p.Leu397Arg Uncertain significance Single submitter
- ATAD3C p.Lys219Glu Uncertain significance Single submitter
- ATAD3C p.Lys23Glu Uncertain significance Single submitter
- ATAD3C p.Lys370Met Uncertain significance Single submitter
- ATAD3C p.Met209Val Uncertain significance Single submitter
- ATAD3C p.Met393Ile Uncertain significance Single submitter
- ATAD3C p.Phe272Cys Likely benign Single submitter
- ATAD3C p.Phe298Cys Uncertain significance Single submitter
- ATAD3C p.Pro147Arg Uncertain significance Single submitter
- ATAD3C p.Pro281Ser Uncertain significance Single submitter
- ATAD3C p.Ser107Phe Uncertain significance Single submitter
- ATAD3C p.Thr112Met Uncertain significance Single submitter
- ATAD3C p.Thr265Arg Uncertain significance Single submitter
- ATAD3C p.Thr72Lys Uncertain significance Single submitter
- ATAD3C p.Thr74Arg Uncertain significance Single submitter
- ATAD3C p.Thr79Met Uncertain significance Single submitter
- ATAD3C p.Tyr170Cys Uncertain significance Single submitter
- ATAD3C p.Val360Met Uncertain significance Single submitter
- ATAD3C p.Val383Ala Uncertain significance Single submitter
- ATAD3C p.Val65Gly Uncertain significance Single submitter
All ATAD3C variants
Conflicting classifications of pathogenicity 1
- p.Arg154Cys Single submitter ⚠
Benign 1
- p.Ala91Val Multiple submitters
Likely benign 11
- p.His172Asn Multiple submitters
- c.1090-8C>T Single submitter
- p.Arg122Gln Single submitter ⚠
- p.Arg338Lys Single submitter
- p.Cys352Gly Single submitter
- p.Gly399Arg Single submitter
- p.Ile163Thr Single submitter
- p.Ile50Asn Single submitter
- p.Lys271= Single submitter
- p.Lys354Glu Single submitter
- p.Phe272Cys Single submitter ⚠
Uncertain significance 110
- p.Ala101Thr Single submitter ⚠
- p.Ala101Val Single submitter ⚠
- p.Ala120Val Single submitter ⚠
- p.Ala157Thr Single submitter ⚠
- p.Ala240Thr Single submitter ⚠
- p.Ala260Thr Single submitter ⚠
- p.Ala277Thr Single submitter ⚠
- p.Ala307Gly Single submitter ⚠
- p.Ala307Val Single submitter ⚠
- p.Ala344Thr Single submitter ⚠
- p.Ala356Thr Single submitter ⚠
- p.Ala368Val Single submitter ⚠
- p.Ala381Val Single submitter ⚠
- p.Ala91Glu Single submitter ⚠
- p.Ala91Gly Single submitter ⚠
- p.Ala93Val Single submitter ⚠
- p.Arg102Trp Single submitter ⚠
- p.Arg110Gly Single submitter ⚠
- p.Arg114Cys Single submitter ⚠
- p.Arg122Gly Single submitter ⚠
- p.Arg122Trp Single submitter ⚠
- p.Arg130Gln Single submitter ⚠
- p.Arg131Gln Single submitter ⚠
- p.Arg135Gln Single submitter ⚠
- p.Arg167Gln Single submitter ⚠
- p.Arg167Trp Single submitter ⚠
- p.Arg211Gln Single submitter ⚠
- p.Arg211Trp Single submitter ⚠
- p.Arg228Gln Single submitter ⚠
- p.Arg228Trp Single submitter ⚠
- p.Arg243Trp Single submitter ⚠
- p.Arg264Cys Single submitter ⚠
- p.Arg306Gln Single submitter ⚠
- p.Arg308Cys Single submitter ⚠
- p.Arg308His Single submitter ⚠
- p.Arg327Trp Single submitter ⚠
- p.Arg33Gln Single submitter ⚠
- p.Arg33Trp Single submitter ⚠
- p.Arg353Gln Single submitter ⚠
- p.Arg395His Single submitter ⚠
- p.Arg68Gln Single submitter ⚠
- p.Asn315Ile Single submitter ⚠
- p.Asp138Gly Single submitter ⚠
- p.Asp285Tyr Single submitter ⚠
- p.Asp293Gly Single submitter ⚠
- p.Asp299Asn Single submitter ⚠
- p.Cys279Tyr Single submitter ⚠
- p.Gln12Arg Single submitter ⚠
- p.Gln35Pro Single submitter ⚠
- p.Glu100Ala Single submitter ⚠
- p.Glu100Gln Single submitter ⚠
- p.Glu237Lys Single submitter ⚠
- p.Glu252Lys Single submitter ⚠
- p.Glu376Ala Single submitter ⚠
- p.Glu376Lys Single submitter ⚠
- p.Glu400Asp Single submitter ⚠
- p.Glu400Gly Single submitter ⚠
- p.Glu400Val Single submitter ⚠
- p.Gly142Ala Single submitter ⚠
- p.Gly177Arg Single submitter ⚠
- p.Gly180Ala Single submitter ⚠
- p.Gly180Val Single submitter ⚠
- p.Gly182Arg Single submitter ⚠
- p.Gly213Asp Single submitter ⚠
- p.Gly230Ser Single submitter ⚠
- p.His280Tyr Single submitter ⚠
- p.Ile288Thr Single submitter ⚠
- p.Ile288Val Single submitter ⚠
- p.Ile99Met Single submitter ⚠
- p.Ile99Val Single submitter ⚠
- p.Leu24Phe Single submitter ⚠
- p.Leu397Arg Single submitter ⚠
- p.Lys164Arg Single submitter ⚠
- p.Lys165Gln Single submitter ⚠
- p.Lys219Glu Single submitter ⚠
- p.Lys23Glu Single submitter ⚠
- p.Lys326Asn Single submitter ⚠
- p.Lys34Arg Single submitter ⚠
- p.Lys354Asn Single submitter ⚠
- p.Lys370Met Single submitter ⚠
- p.Met159Ile Single submitter ⚠
- p.Met209Val Single submitter ⚠
- p.Met312Thr Single submitter ⚠
- p.Met379Ile Single submitter ⚠
- p.Met393Ile Single submitter ⚠
- p.Phe234Leu Single submitter ⚠
- p.Phe298Cys Single submitter ⚠
- p.Phe298Leu Single submitter ⚠
- p.Pro147Arg Single submitter ⚠
- p.Pro281Ser Single submitter ⚠
- p.Pro409His Single submitter ⚠
- p.Ser107Phe Single submitter ⚠
- p.Thr112Met Single submitter ⚠
- p.Thr15Met Single submitter ⚠
- p.Thr265Arg Single submitter ⚠
- p.Thr265Met Single submitter ⚠
- p.Thr45Ile Single submitter ⚠
- p.Thr66Arg Single submitter ⚠
- p.Thr72Lys Single submitter ⚠
- p.Thr74Arg Single submitter ⚠
- p.Thr79Ala Single submitter ⚠
- p.Thr79Met Single submitter ⚠
- p.Thr92Ile Single submitter ⚠
- p.Tyr170Cys Single submitter ⚠
- p.Val153Leu Single submitter ⚠
- p.Val360Met Single submitter ⚠
- p.Val373Ile Single submitter ⚠
- p.Val383Ala Single submitter ⚠
- p.Val65Gly Single submitter ⚠
- p.Val94Ala Single submitter ⚠