ATF1 — 36 ClinVar variants
All ClinVar germline ATF1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
2 Benign · 34 Uncertain significance
Full ATF1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ATF1 p.Arg244Gly Uncertain significance Single submitter
- ATF1 p.Arg61His Uncertain significance Single submitter
- ATF1 p.Arg77Gln Uncertain significance Single submitter
- ATF1 p.Asp46Asn Uncertain significance Single submitter
- ATF1 p.Asp82Asn Uncertain significance Single submitter
- ATF1 p.Glu257Lys Uncertain significance Single submitter
- ATF1 p.Gly56Arg Uncertain significance Single submitter
- ATF1 p.Ile48Thr Uncertain significance Single submitter
- ATF1 p.Leu190Pro Uncertain significance Single submitter
- ATF1 p.Lys69Glu Uncertain significance Single submitter
- ATF1 p.Lys6Glu Uncertain significance Single submitter
- ATF1 p.Met136Lys Uncertain significance Single submitter
- ATF1 p.Met136Val Uncertain significance Single submitter
- ATF1 p.Pro14Leu Uncertain significance Single submitter
- ATF1 p.Pro14Thr Uncertain significance Single submitter
- ATF1 p.Pro163Ser Uncertain significance Single submitter
- ATF1 p.Thr184Ile Uncertain significance Single submitter
- ATF1 p.Thr254Ile Uncertain significance Single submitter
- ATF1 p.Val238Met Uncertain significance Single submitter
- ATF1 p.Val97Ile Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- ATF1 p.Asn165Ser Uncertain significance Single submitter
- ATF1 p.Gln129His Uncertain significance Single submitter
- ATF1 p.Gly124Arg Uncertain significance Single submitter
- ATF1 p.Ile148Thr Uncertain significance Single submitter
- ATF1 p.Leu202Phe Uncertain significance Single submitter
- ATF1 p.Leu265Val Uncertain significance Single submitter
- ATF1 p.Lys53Asn Uncertain significance Single submitter
- ATF1 p.Met136Ile Uncertain significance Single submitter
- ATF1 p.Met176Ile Uncertain significance Single submitter
- ATF1 p.Met176Thr Uncertain significance Single submitter
- ATF1 p.Ser106Gly Uncertain significance Single submitter
- ATF1 p.Thr93Ile Uncertain significance Single submitter
- ATF1 p.Val92Ile Uncertain significance Single submitter
- ATF1 p.Val97Phe Uncertain significance Single submitter
All ATF1 variants
Benign 2
- p.Tyr109= Multiple submitters
- c.-6-4815T>G Single submitter
Uncertain significance 34
- p.Arg244Gly Single submitter ⚠
- p.Arg61His Single submitter ⚠
- p.Arg77Gln Single submitter ⚠
- p.Asn165Ser Single submitter ⚠
- p.Asp46Asn Single submitter ⚠
- p.Asp82Asn Single submitter ⚠
- p.Gln129His Single submitter ⚠
- p.Glu257Lys Single submitter ⚠
- p.Gly124Arg Single submitter ⚠
- p.Gly56Arg Single submitter ⚠
- p.Ile148Thr Single submitter ⚠
- p.Ile48Thr Single submitter ⚠
- p.Leu190Pro Single submitter ⚠
- p.Leu202Phe Single submitter ⚠
- p.Leu265Val Single submitter ⚠
- p.Lys53Asn Single submitter ⚠
- p.Lys69Glu Single submitter ⚠
- p.Lys6Glu Single submitter ⚠
- p.Met136Ile Single submitter ⚠
- p.Met136Lys Single submitter ⚠
- p.Met136Val Single submitter ⚠
- p.Met176Ile Single submitter ⚠
- p.Met176Thr Single submitter ⚠
- p.Pro14Leu Single submitter ⚠
- p.Pro14Thr Single submitter ⚠
- p.Pro163Ser Single submitter ⚠
- p.Ser106Gly Single submitter ⚠
- p.Thr184Ile Single submitter ⚠
- p.Thr254Ile Single submitter ⚠
- p.Thr93Ile Single submitter ⚠
- p.Val238Met Single submitter ⚠
- p.Val92Ile Single submitter ⚠
- p.Val97Ile Single submitter ⚠
- p.Val97Phe Single submitter ⚠