ATF2 — 51 ClinVar variants
All ClinVar germline ATF2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →
2 Benign · 1 Likely benign · 48 Uncertain significance
Full ATF2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 48
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ATF2 p.Ala244Thr Uncertain significance Single submitter
- ATF2 p.Ala422Thr Uncertain significance Single submitter
- ATF2 p.Ala422Val Uncertain significance Single submitter
- ATF2 p.Ala469Val Uncertain significance Single submitter
- ATF2 p.Ala481Val Uncertain significance Single submitter
- ATF2 p.Arg250Gln Uncertain significance Single submitter
- ATF2 p.Arg343Trp Uncertain significance Single submitter
- ATF2 p.Asn173Ser Uncertain significance Single submitter
- ATF2 p.Asn362Lys Uncertain significance Single submitter
- ATF2 p.Asn461Ser Uncertain significance Single submitter
- ATF2 p.Asn94Lys Uncertain significance Single submitter
- ATF2 p.Asp22Tyr Uncertain significance Single submitter
- ATF2 p.Asp433Ala Uncertain significance Single submitter
- ATF2 p.Gln313Pro Uncertain significance Single submitter
- ATF2 p.Gly301Arg Uncertain significance Single submitter
- ATF2 p.His220Arg Uncertain significance Single submitter
- ATF2 p.His448Arg Uncertain significance Single submitter
- ATF2 p.Ile118Val Uncertain significance Single submitter
- ATF2 p.Lys426Gln Uncertain significance Single submitter
- ATF2 p.Lys468Asn Uncertain significance Single submitter
- ATF2 p.Lys4Arg Uncertain significance Single submitter
- ATF2 p.Pro139Leu Uncertain significance Single submitter
- ATF2 p.Pro141Ala Uncertain significance Single submitter
- ATF2 p.Pro232Arg Uncertain significance Single submitter
- ATF2 p.Pro243Ser Uncertain significance Single submitter
- ATF2 p.Pro259Ala Uncertain significance Single submitter
- ATF2 p.Pro312Leu Uncertain significance Single submitter
- ATF2 p.Ser396Asn Uncertain significance Single submitter
- ATF2 p.Ser438Thr Uncertain significance Single submitter
- ATF2 p.Ser442Thr Uncertain significance Single submitter
- ATF2 p.Thr322Ala Uncertain significance Single submitter
- ATF2 p.Thr449Ile Uncertain significance Single submitter
- ATF2 p.Thr459Ala Uncertain significance Single submitter
- ATF2 p.Thr466Ile Uncertain significance Single submitter
- ATF2 p.Val211Leu Uncertain significance Single submitter
- ATF2 p.Val463Ala Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- ATF2 p.Gln499Arg Uncertain significance Single submitter
- ATF2 p.Gly428Ser Uncertain significance Single submitter
- ATF2 p.His331Tyr Uncertain significance Single submitter
- ATF2 p.Met51Ile Uncertain significance Single submitter
- ATF2 p.Pro126Leu Uncertain significance Single submitter
- ATF2 p.Pro159Arg Uncertain significance Single submitter
- ATF2 p.Pro159His Uncertain significance Single submitter
- ATF2 p.Pro269Arg Uncertain significance Single submitter
- ATF2 p.Ser300Arg Uncertain significance Single submitter
- ATF2 p.Ser338Asn Uncertain significance Single submitter
- ATF2 p.Thr305Ile Uncertain significance Single submitter
- ATF2 p.Val255Leu Uncertain significance Single submitter
All ATF2 variants
Likely benign 1
- p.Gln501= Single submitter
Uncertain significance 48
- p.Ala244Thr Single submitter ⚠
- p.Ala422Thr Single submitter ⚠
- p.Ala422Val Single submitter ⚠
- p.Ala469Val Single submitter ⚠
- p.Ala481Val Single submitter ⚠
- p.Arg250Gln Single submitter ⚠
- p.Arg343Trp Single submitter ⚠
- p.Asn173Ser Single submitter ⚠
- p.Asn362Lys Single submitter ⚠
- p.Asn461Ser Single submitter ⚠
- p.Asn94Lys Single submitter ⚠
- p.Asp22Tyr Single submitter ⚠
- p.Asp433Ala Single submitter ⚠
- p.Gln313Pro Single submitter ⚠
- p.Gln499Arg Single submitter ⚠
- p.Gly301Arg Single submitter ⚠
- p.Gly428Ser Single submitter ⚠
- p.His220Arg Single submitter ⚠
- p.His331Tyr Single submitter ⚠
- p.His448Arg Single submitter ⚠
- p.Ile118Val Single submitter ⚠
- p.Lys426Gln Single submitter ⚠
- p.Lys468Asn Single submitter ⚠
- p.Lys4Arg Single submitter ⚠
- p.Met51Ile Single submitter ⚠
- p.Pro126Leu Single submitter ⚠
- p.Pro139Leu Single submitter ⚠
- p.Pro141Ala Single submitter ⚠
- p.Pro159Arg Single submitter ⚠
- p.Pro159His Single submitter ⚠
- p.Pro232Arg Single submitter ⚠
- p.Pro243Ser Single submitter ⚠
- p.Pro259Ala Single submitter ⚠
- p.Pro269Arg Single submitter ⚠
- p.Pro312Leu Single submitter ⚠
- p.Ser300Arg Single submitter ⚠
- p.Ser338Asn Single submitter ⚠
- p.Ser396Asn Single submitter ⚠
- p.Ser438Thr Single submitter ⚠
- p.Ser442Thr Single submitter ⚠
- p.Thr305Ile Single submitter ⚠
- p.Thr322Ala Single submitter ⚠
- p.Thr449Ile Single submitter ⚠
- p.Thr459Ala Single submitter ⚠
- p.Thr466Ile Single submitter ⚠
- p.Val211Leu Single submitter ⚠
- p.Val255Leu Single submitter ⚠
- p.Val463Ala Single submitter ⚠