ATF3 — 26 ClinVar variants
All ClinVar germline ATF3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 18 flagged for review →
2 Benign · 6 Likely benign · 18 Uncertain significance
Full ATF3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 18
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ATF3 p.Ser12Pro Uncertain significance Multiple submitters
- ATF3 p.Ala82Val Uncertain significance Single submitter
- ATF3 p.Asp69Asn Uncertain significance Single submitter
- ATF3 p.Glu32Lys Uncertain significance Single submitter
- ATF3 p.Ile171Thr Uncertain significance Single submitter
- ATF3 p.Leu146Phe Uncertain significance Single submitter
- ATF3 p.Pro26Ser Uncertain significance Single submitter
- ATF3 p.Thr66Ser Uncertain significance Single submitter
- ATF3 p.Val20Ile Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- ATF3 p.Asn168Ile Uncertain significance Single submitter
- ATF3 p.Gln115Glu Uncertain significance Single submitter
- ATF3 p.Glu80Lys Uncertain significance Single submitter
- ATF3 p.Leu54Phe Uncertain significance Single submitter
- ATF3 p.Lys136Glu Uncertain significance Single submitter
- ATF3 p.Lys42Glu Uncertain significance Single submitter
- ATF3 p.Ser24Cys Uncertain significance Single submitter
- ATF3 p.Ser24Phe Uncertain significance Single submitter
- ATF3 p.Thr38Met Uncertain significance Single submitter
All ATF3 variants
Likely benign 6
Uncertain significance 18
- p.Ser12Pro Multiple submitters ⚠
- p.Ala82Val Single submitter ⚠
- p.Asn168Ile Single submitter ⚠
- p.Asp69Asn Single submitter ⚠
- p.Gln115Glu Single submitter ⚠
- p.Glu32Lys Single submitter ⚠
- p.Glu80Lys Single submitter ⚠
- p.Ile171Thr Single submitter ⚠
- p.Leu146Phe Single submitter ⚠
- p.Leu54Phe Single submitter ⚠
- p.Lys136Glu Single submitter ⚠
- p.Lys42Glu Single submitter ⚠
- p.Pro26Ser Single submitter ⚠
- p.Ser24Cys Single submitter ⚠
- p.Ser24Phe Single submitter ⚠
- p.Thr38Met Single submitter ⚠
- p.Thr66Ser Single submitter ⚠
- p.Val20Ile Single submitter ⚠