ATF4 — 89 ClinVar variants
All ClinVar germline ATF4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 78 flagged for review →
10 Benign · 4 Likely benign · 75 Uncertain significance
Full ATF4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 78
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 52
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ATF4 p.Ala202Pro Uncertain significance Single submitter
- ATF4 p.Ala256Gly Uncertain significance Single submitter
- ATF4 p.Ala301Val Uncertain significance Single submitter
- ATF4 p.Ala305Val Uncertain significance Single submitter
- ATF4 p.Ala328Val Uncertain significance Single submitter
- ATF4 p.Ala78Val Uncertain significance Single submitter
- ATF4 p.Asn217Ser Uncertain significance Single submitter
- ATF4 p.Asn288Ser Uncertain significance Single submitter
- ATF4 p.Asp110Gly Uncertain significance Single submitter
- ATF4 p.Asp187Gly Uncertain significance Single submitter
- ATF4 p.Asp196Asn Uncertain significance Single submitter
- ATF4 p.Asp262Asn Uncertain significance Single submitter
- ATF4 p.Asp262Tyr Uncertain significance Single submitter
- ATF4 p.Asp52Glu Uncertain significance Single submitter
- ATF4 p.Gln136Lys Uncertain significance Single submitter
- ATF4 p.Gln161Lys Uncertain significance Single submitter
- ATF4 p.Glu266Gln Uncertain significance Single submitter
- ATF4 p.Gly168Arg Uncertain significance Single submitter
- ATF4 p.Gly308Ser Uncertain significance Single submitter
- ATF4 p.Gly32Asp Uncertain significance Single submitter
- ATF4 p.Gly57Asp Uncertain significance Single submitter
- ATF4 p.His43Pro Uncertain significance Single submitter
- ATF4 p.His47Tyr Uncertain significance Single submitter
- ATF4 p.Ile102Val Uncertain significance Single submitter
- ATF4 p.Ile141Val Uncertain significance Single submitter
- ATF4 p.Leu105Val Uncertain significance Single submitter
- ATF4 p.Leu163Phe Uncertain significance Single submitter
- ATF4 p.Leu16Ser Uncertain significance Single submitter
- ATF4 p.Leu229Val Uncertain significance Single submitter
- ATF4 p.Leu278Val Uncertain significance Single submitter
- ATF4 p.Leu320Val Uncertain significance Single submitter
- ATF4 p.Lys299Arg Uncertain significance Single submitter
- ATF4 p.Met268Ile Uncertain significance Single submitter
- ATF4 p.Met268Thr Uncertain significance Single submitter
- ATF4 p.Phe49Val Uncertain significance Single submitter
- ATF4 p.Phe79Cys Uncertain significance Single submitter
- ATF4 p.Pro125Ser Uncertain significance Single submitter
- ATF4 p.Pro134Leu Uncertain significance Single submitter
- ATF4 p.Pro162Ser Uncertain significance Single submitter
- ATF4 p.Pro205Ser Uncertain significance Single submitter
- ATF4 p.Pro249Ser Uncertain significance Single submitter
- ATF4 p.Pro258Leu Uncertain significance Single submitter
- ATF4 p.Pro351Leu Uncertain significance Single submitter
- ATF4 p.Pro351Ser Uncertain significance Single submitter
- ATF4 p.Ser147Gly Uncertain significance Single submitter
- ATF4 p.Ser172Pro Uncertain significance Single submitter
- ATF4 p.Ser255Phe Uncertain significance Single submitter
- ATF4 p.Ser30Asn Uncertain significance Single submitter
- ATF4 p.Ser8Gly Uncertain significance Single submitter
- ATF4 p.Thr189Pro Uncertain significance Single submitter
- ATF4 p.Thr213Ile Uncertain significance Single submitter
- ATF4 p.Val169Ile Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- ATF4 p.Glu322Asp Benign Multiple submitters
- ATF4 p.Glu3Lys Benign Multiple submitters
- ATF4 p.Ile208Met Likely benign Multiple submitters
- ATF4 p.Ala199Val Uncertain significance Single submitter
- ATF4 p.Arg257Cys Uncertain significance Single submitter
- ATF4 p.Arg342Cys Uncertain significance Single submitter
- ATF4 p.Asp118Ala Uncertain significance Single submitter
- ATF4 p.Asp121Val Uncertain significance Single submitter
- ATF4 p.Asp279Val Uncertain significance Single submitter
- ATF4 p.Asp83Val Uncertain significance Single submitter
- ATF4 p.Glu312Lys Uncertain significance Single submitter
- ATF4 p.Glu60Lys Uncertain significance Single submitter
- ATF4 p.Gly66Arg Uncertain significance Single submitter
- ATF4 p.Leu116Trp Uncertain significance Single submitter
- ATF4 p.Leu122Phe Uncertain significance Single submitter
- ATF4 p.Leu25Trp Uncertain significance Single submitter
- ATF4 p.Lys194Gln Uncertain significance Single submitter
- ATF4 p.Lys274Arg Uncertain significance Single submitter
- ATF4 p.Pro134His Uncertain significance Single submitter
- ATF4 p.Pro162Leu Uncertain significance Single submitter
- ATF4 p.Ser235Gly Uncertain significance Single submitter
- ATF4 p.Ser248Phe Uncertain significance Single submitter
- ATF4 p.Ser58Phe Uncertain significance Single submitter
- ATF4 p.Ser71Phe Uncertain significance Single submitter
- ATF4 p.Ser80Phe Uncertain significance Single submitter
- ATF4 p.Thr307Ile Uncertain significance Single submitter
All ATF4 variants
Benign 10
- p.Ala324Val Multiple submitters
- p.Asn131= Multiple submitters
- p.Glu322Asp Multiple submitters ⚠
- p.Glu3Lys Multiple submitters ⚠
- p.Pro258Ala Multiple submitters
- p.Tyr200= Multiple submitters
- p.Val201Ile Multiple submitters
- p.Pro135Leu Single submitter
- p.Ser166= Single submitter
- p.Ser80= Single submitter
Likely benign 4
- p.Ile208Met Multiple submitters ⚠
- p.Thr137Ser Multiple submitters
- p.Arg193= Single submitter
- p.Glu304= Single submitter
Uncertain significance 75
- p.Ala199Val Single submitter ⚠
- p.Ala202Pro Single submitter ⚠
- p.Ala256Gly Single submitter ⚠
- p.Ala301Val Single submitter ⚠
- p.Ala305Val Single submitter ⚠
- p.Ala328Val Single submitter ⚠
- p.Ala78Val Single submitter ⚠
- p.Arg257Cys Single submitter ⚠
- p.Arg342Cys Single submitter ⚠
- p.Asn217Ser Single submitter ⚠
- p.Asn288Ser Single submitter ⚠
- p.Asp110Gly Single submitter ⚠
- p.Asp118Ala Single submitter ⚠
- p.Asp121Val Single submitter ⚠
- p.Asp187Gly Single submitter ⚠
- p.Asp196Asn Single submitter ⚠
- p.Asp262Asn Single submitter ⚠
- p.Asp262Tyr Single submitter ⚠
- p.Asp279Val Single submitter ⚠
- p.Asp52Glu Single submitter ⚠
- p.Asp83Val Single submitter ⚠
- p.Gln136Lys Single submitter ⚠
- p.Gln161Lys Single submitter ⚠
- p.Glu266Gln Single submitter ⚠
- p.Glu312Lys Single submitter ⚠
- p.Glu60Lys Single submitter ⚠
- p.Gly168Arg Single submitter ⚠
- p.Gly308Ser Single submitter ⚠
- p.Gly32Asp Single submitter ⚠
- p.Gly57Asp Single submitter ⚠
- p.Gly66Arg Single submitter ⚠
- p.His43Pro Single submitter ⚠
- p.His47Tyr Single submitter ⚠
- p.Ile102Val Single submitter ⚠
- p.Ile141Val Single submitter ⚠
- p.Leu105Val Single submitter ⚠
- p.Leu116Trp Single submitter ⚠
- p.Leu122Phe Single submitter ⚠
- p.Leu163Phe Single submitter ⚠
- p.Leu16Ser Single submitter ⚠
- p.Leu229Val Single submitter ⚠
- p.Leu25Trp Single submitter ⚠
- p.Leu278Val Single submitter ⚠
- p.Leu320Val Single submitter ⚠
- p.Lys194Gln Single submitter ⚠
- p.Lys274Arg Single submitter ⚠
- p.Lys299Arg Single submitter ⚠
- p.Met268Ile Single submitter ⚠
- p.Met268Thr Single submitter ⚠
- p.Phe49Val Single submitter ⚠
- p.Phe79Cys Single submitter ⚠
- p.Pro125Ser Single submitter ⚠
- p.Pro134His Single submitter ⚠
- p.Pro134Leu Single submitter ⚠
- p.Pro162Leu Single submitter ⚠
- p.Pro162Ser Single submitter ⚠
- p.Pro205Ser Single submitter ⚠
- p.Pro249Ser Single submitter ⚠
- p.Pro258Leu Single submitter ⚠
- p.Pro351Leu Single submitter ⚠
- p.Pro351Ser Single submitter ⚠
- p.Ser147Gly Single submitter ⚠
- p.Ser172Pro Single submitter ⚠
- p.Ser235Gly Single submitter ⚠
- p.Ser248Phe Single submitter ⚠
- p.Ser255Phe Single submitter ⚠
- p.Ser30Asn Single submitter ⚠
- p.Ser58Phe Single submitter ⚠
- p.Ser71Phe Single submitter ⚠
- p.Ser80Phe Single submitter ⚠
- p.Ser8Gly Single submitter ⚠
- p.Thr189Pro Single submitter ⚠
- p.Thr213Ile Single submitter ⚠
- p.Thr307Ile Single submitter ⚠
- p.Val169Ile Single submitter ⚠