ATF5 — 20 ClinVar variants
All ClinVar germline ATF5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 18 flagged for review →
2 Benign · 18 Uncertain significance
Full ATF5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 18
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ATF5 p.Ala102Gly Uncertain significance Single submitter
- ATF5 p.Ala35Thr Uncertain significance Single submitter
- ATF5 p.Arg253Trp Uncertain significance Single submitter
- ATF5 p.Gln193Pro Uncertain significance Single submitter
- ATF5 p.Glu110Gln Uncertain significance Single submitter
- ATF5 p.Leu143Pro Uncertain significance Single submitter
- ATF5 p.Pro85Ala Uncertain significance Single submitter
- ATF5 p.Tyr200Cys Uncertain significance Single submitter
- ATF5 p.Tyr40Ser Uncertain significance Single submitter
- ATF5 p.Val175Leu Uncertain significance Single submitter
- ATF5 p.Val264Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- ATF5 p.Glu110Gly Uncertain significance Single submitter
- ATF5 p.Gly45Val Uncertain significance Single submitter
- ATF5 p.Gly54Arg Uncertain significance Single submitter
- ATF5 p.Leu122Phe Uncertain significance Single submitter
- ATF5 p.Pro123Arg Uncertain significance Single submitter
- ATF5 p.Pro186Thr Uncertain significance Single submitter
- ATF5 p.Pro191Ala Uncertain significance Single submitter
All ATF5 variants
Uncertain significance 18
- p.Ala102Gly Single submitter ⚠
- p.Ala35Thr Single submitter ⚠
- p.Arg253Trp Single submitter ⚠
- p.Gln193Pro Single submitter ⚠
- p.Glu110Gln Single submitter ⚠
- p.Glu110Gly Single submitter ⚠
- p.Gly45Val Single submitter ⚠
- p.Gly54Arg Single submitter ⚠
- p.Leu122Phe Single submitter ⚠
- p.Leu143Pro Single submitter ⚠
- p.Pro123Arg Single submitter ⚠
- p.Pro186Thr Single submitter ⚠
- p.Pro191Ala Single submitter ⚠
- p.Pro85Ala Single submitter ⚠
- p.Tyr200Cys Single submitter ⚠
- p.Tyr40Ser Single submitter ⚠
- p.Val175Leu Single submitter ⚠
- p.Val264Ile Single submitter ⚠