ATF7IP2 — 113 ClinVar variants
All ClinVar germline ATF7IP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 99 flagged for review →
14 Likely benign · 99 Uncertain significance
Full ATF7IP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 99
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 75
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ATF7IP2 p.Ala134Ser Uncertain significance Single submitter
- ATF7IP2 p.Ala161Gly Uncertain significance Single submitter
- ATF7IP2 p.Ala161Thr Uncertain significance Single submitter
- ATF7IP2 p.Ala361Thr Uncertain significance Single submitter
- ATF7IP2 p.Ala366Val Uncertain significance Single submitter
- ATF7IP2 p.Ala540Ser Uncertain significance Single submitter
- ATF7IP2 p.Ala74Val Uncertain significance Single submitter
- ATF7IP2 p.Arg128Ile Uncertain significance Single submitter
- ATF7IP2 p.Arg23Gln Uncertain significance Single submitter
- ATF7IP2 p.Arg664Gln Uncertain significance Single submitter
- ATF7IP2 p.Asn206Ser Uncertain significance Single submitter
- ATF7IP2 p.Asn242Asp Uncertain significance Single submitter
- ATF7IP2 p.Asn261Asp Uncertain significance Single submitter
- ATF7IP2 p.Asn261Ile Uncertain significance Single submitter
- ATF7IP2 p.Asn293Asp Uncertain significance Single submitter
- ATF7IP2 p.Asn465Ser Uncertain significance Single submitter
- ATF7IP2 p.Asn484Ser Uncertain significance Single submitter
- ATF7IP2 p.Asn532Asp Uncertain significance Single submitter
- ATF7IP2 p.Asn621Asp Uncertain significance Single submitter
- ATF7IP2 p.Asp78His Uncertain significance Single submitter
- ATF7IP2 p.Cys254Tyr Uncertain significance Single submitter
- ATF7IP2 p.Cys308Tyr Uncertain significance Single submitter
- ATF7IP2 p.Gln214Leu Uncertain significance Single submitter
- ATF7IP2 p.Gln444Lys Uncertain significance Single submitter
- ATF7IP2 p.Gln541His Uncertain significance Single submitter
- ATF7IP2 p.Glu157Gly Uncertain significance Single submitter
- ATF7IP2 p.Glu358Lys Uncertain significance Single submitter
- ATF7IP2 p.Glu403Asp Uncertain significance Single submitter
- ATF7IP2 p.Glu535Lys Uncertain significance Single submitter
- ATF7IP2 p.Gly225Ser Uncertain significance Single submitter
- ATF7IP2 p.His158Tyr Uncertain significance Single submitter
- ATF7IP2 p.His200Arg Uncertain significance Single submitter
- ATF7IP2 p.His210Gln Uncertain significance Single submitter
- ATF7IP2 p.His280Arg Uncertain significance Single submitter
- ATF7IP2 p.Ile248Phe Uncertain significance Single submitter
- ATF7IP2 p.Ile332Thr Uncertain significance Single submitter
- ATF7IP2 p.Ile360Thr Uncertain significance Single submitter
- ATF7IP2 p.Ile438Met Uncertain significance Single submitter
- ATF7IP2 p.Ile58Val Uncertain significance Single submitter
- ATF7IP2 p.Ile598Val Uncertain significance Single submitter
- ATF7IP2 p.Ile632Ser Uncertain significance Single submitter
- ATF7IP2 p.Leu38Pro Uncertain significance Single submitter
- ATF7IP2 p.Lys350Asn Uncertain significance Single submitter
- ATF7IP2 p.Lys363Asn Uncertain significance Single submitter
- ATF7IP2 p.Lys534Arg Uncertain significance Single submitter
- ATF7IP2 p.Lys600Arg Uncertain significance Single submitter
- ATF7IP2 p.Met18Val Uncertain significance Single submitter
- ATF7IP2 p.Met286Ile Uncertain significance Single submitter
- ATF7IP2 p.Met297Leu Uncertain significance Single submitter
- ATF7IP2 p.Met297Lys Uncertain significance Single submitter
- ATF7IP2 p.Met297Val Uncertain significance Single submitter
- ATF7IP2 p.Met390Ile Uncertain significance Single submitter
- ATF7IP2 p.Met390Thr Uncertain significance Single submitter
- ATF7IP2 p.Phe677Ile Uncertain significance Single submitter
- ATF7IP2 p.Pro489Ser Uncertain significance Single submitter
- ATF7IP2 p.Pro4Thr Uncertain significance Single submitter
- ATF7IP2 p.Pro575Thr Uncertain significance Single submitter
- ATF7IP2 p.Pro98Ala Uncertain significance Single submitter
- ATF7IP2 p.Ser115Leu Uncertain significance Single submitter
- ATF7IP2 p.Ser421Pro Uncertain significance Single submitter
- ATF7IP2 p.Ser48Asn Uncertain significance Single submitter
- ATF7IP2 p.Ser502Cys Uncertain significance Single submitter
- ATF7IP2 p.Ser527Leu Uncertain significance Single submitter
- ATF7IP2 p.Ser533Leu Uncertain significance Single submitter
- ATF7IP2 p.Thr40Arg Uncertain significance Single submitter
- ATF7IP2 p.Thr468Ser Uncertain significance Single submitter
- ATF7IP2 p.Thr475Ala Uncertain significance Single submitter
- ATF7IP2 p.Thr481Pro Uncertain significance Single submitter
- ATF7IP2 p.Val113Asp Uncertain significance Single submitter
- ATF7IP2 p.Val198Ile Uncertain significance Single submitter
- ATF7IP2 p.Val236Leu Uncertain significance Single submitter
- ATF7IP2 p.Val321Ile Uncertain significance Single submitter
- ATF7IP2 p.Val448Ile Uncertain significance Single submitter
- ATF7IP2 p.Val546Ala Uncertain significance Single submitter
- ATF7IP2 p.Val99Leu Uncertain significance Single submitter
Predictors split 24
The independent predictors disagree with each other — read with care.
- ATF7IP2 p.Arg23Trp Uncertain significance Single submitter
- ATF7IP2 p.Arg313Gly Uncertain significance Single submitter
- ATF7IP2 p.Arg585Trp Uncertain significance Single submitter
- ATF7IP2 p.Arg9Trp Uncertain significance Single submitter
- ATF7IP2 p.Asn424His Uncertain significance Single submitter
- ATF7IP2 p.Asp223His Uncertain significance Single submitter
- ATF7IP2 p.Asp568His Uncertain significance Single submitter
- ATF7IP2 p.Glu27Lys Uncertain significance Single submitter
- ATF7IP2 p.Glu509Gln Uncertain significance Single submitter
- ATF7IP2 p.Glu535Gly Uncertain significance Single submitter
- ATF7IP2 p.Ile11Thr Uncertain significance Single submitter
- ATF7IP2 p.Leu466Met Uncertain significance Single submitter
- ATF7IP2 p.Leu553Pro Uncertain significance Single submitter
- ATF7IP2 p.Leu556Pro Uncertain significance Single submitter
- ATF7IP2 p.Lys604Asn Uncertain significance Single submitter
- ATF7IP2 p.Phe337Leu Uncertain significance Single submitter
- ATF7IP2 p.Pro579Arg Uncertain significance Single submitter
- ATF7IP2 p.Ser187Gly Uncertain significance Single submitter
- ATF7IP2 p.Ser79Cys Uncertain significance Single submitter
- ATF7IP2 p.Thr315Ile Uncertain significance Single submitter
- ATF7IP2 p.Thr61Met Uncertain significance Single submitter
- ATF7IP2 p.Val189Met Uncertain significance Single submitter
- ATF7IP2 p.Val26Gly Uncertain significance Single submitter
- ATF7IP2 p.Val656Ile Uncertain significance Single submitter
All ATF7IP2 variants
Likely benign 14
- p.Asn487Ser Single submitter
- p.Asp252Asn Single submitter
- p.Ile418Val Single submitter
- p.Ile503Val Single submitter
- p.Ile84Val Single submitter
- p.Pro69His Single submitter
- p.Ser187Asn Single submitter
- p.Ser215Asn Single submitter
- p.Ser44Asn Single submitter
- p.Thr131Ile Single submitter
- p.Thr240Ile Single submitter
- p.Thr377= Single submitter
- p.Thr59Ser Single submitter
- p.Val151Ile Single submitter
Uncertain significance 99
- p.Ala134Ser Single submitter ⚠
- p.Ala161Gly Single submitter ⚠
- p.Ala161Thr Single submitter ⚠
- p.Ala361Thr Single submitter ⚠
- p.Ala366Val Single submitter ⚠
- p.Ala540Ser Single submitter ⚠
- p.Ala74Val Single submitter ⚠
- p.Arg128Ile Single submitter ⚠
- p.Arg23Gln Single submitter ⚠
- p.Arg23Trp Single submitter ⚠
- p.Arg313Gly Single submitter ⚠
- p.Arg585Trp Single submitter ⚠
- p.Arg664Gln Single submitter ⚠
- p.Arg9Trp Single submitter ⚠
- p.Asn206Ser Single submitter ⚠
- p.Asn242Asp Single submitter ⚠
- p.Asn261Asp Single submitter ⚠
- p.Asn261Ile Single submitter ⚠
- p.Asn293Asp Single submitter ⚠
- p.Asn424His Single submitter ⚠
- p.Asn465Ser Single submitter ⚠
- p.Asn484Ser Single submitter ⚠
- p.Asn532Asp Single submitter ⚠
- p.Asn621Asp Single submitter ⚠
- p.Asp223His Single submitter ⚠
- p.Asp568His Single submitter ⚠
- p.Asp78His Single submitter ⚠
- p.Cys254Tyr Single submitter ⚠
- p.Cys308Tyr Single submitter ⚠
- p.Gln214Leu Single submitter ⚠
- p.Gln444Lys Single submitter ⚠
- p.Gln541His Single submitter ⚠
- p.Glu157Gly Single submitter ⚠
- p.Glu27Lys Single submitter ⚠
- p.Glu358Lys Single submitter ⚠
- p.Glu403Asp Single submitter ⚠
- p.Glu509Gln Single submitter ⚠
- p.Glu535Gly Single submitter ⚠
- p.Glu535Lys Single submitter ⚠
- p.Gly225Ser Single submitter ⚠
- p.His158Tyr Single submitter ⚠
- p.His200Arg Single submitter ⚠
- p.His210Gln Single submitter ⚠
- p.His280Arg Single submitter ⚠
- p.Ile11Thr Single submitter ⚠
- p.Ile248Phe Single submitter ⚠
- p.Ile332Thr Single submitter ⚠
- p.Ile360Thr Single submitter ⚠
- p.Ile438Met Single submitter ⚠
- p.Ile58Val Single submitter ⚠
- p.Ile598Val Single submitter ⚠
- p.Ile632Ser Single submitter ⚠
- p.Leu38Pro Single submitter ⚠
- p.Leu466Met Single submitter ⚠
- p.Leu553Pro Single submitter ⚠
- p.Leu556Pro Single submitter ⚠
- p.Lys350Asn Single submitter ⚠
- p.Lys363Asn Single submitter ⚠
- p.Lys534Arg Single submitter ⚠
- p.Lys600Arg Single submitter ⚠
- p.Lys604Asn Single submitter ⚠
- p.Met18Val Single submitter ⚠
- p.Met286Ile Single submitter ⚠
- p.Met297Leu Single submitter ⚠
- p.Met297Lys Single submitter ⚠
- p.Met297Val Single submitter ⚠
- p.Met390Ile Single submitter ⚠
- p.Met390Thr Single submitter ⚠
- p.Phe337Leu Single submitter ⚠
- p.Phe677Ile Single submitter ⚠
- p.Pro489Ser Single submitter ⚠
- p.Pro4Thr Single submitter ⚠
- p.Pro575Thr Single submitter ⚠
- p.Pro579Arg Single submitter ⚠
- p.Pro98Ala Single submitter ⚠
- p.Ser115Leu Single submitter ⚠
- p.Ser187Gly Single submitter ⚠
- p.Ser421Pro Single submitter ⚠
- p.Ser48Asn Single submitter ⚠
- p.Ser502Cys Single submitter ⚠
- p.Ser527Leu Single submitter ⚠
- p.Ser533Leu Single submitter ⚠
- p.Ser79Cys Single submitter ⚠
- p.Thr315Ile Single submitter ⚠
- p.Thr40Arg Single submitter ⚠
- p.Thr468Ser Single submitter ⚠
- p.Thr475Ala Single submitter ⚠
- p.Thr481Pro Single submitter ⚠
- p.Thr61Met Single submitter ⚠
- p.Val113Asp Single submitter ⚠
- p.Val189Met Single submitter ⚠
- p.Val198Ile Single submitter ⚠
- p.Val236Leu Single submitter ⚠
- p.Val26Gly Single submitter ⚠
- p.Val321Ile Single submitter ⚠
- p.Val448Ile Single submitter ⚠
- p.Val546Ala Single submitter ⚠
- p.Val656Ile Single submitter ⚠
- p.Val99Leu Single submitter ⚠