ATG101 — 30 ClinVar variants
All ClinVar germline ATG101 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
1 Likely benign · 29 Uncertain significance
Full ATG101 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ATG101 p.Ala130Ser Uncertain significance Single submitter
- ATG101 p.Arg109His Uncertain significance Single submitter
- ATG101 p.Arg183Gln Uncertain significance Single submitter
- ATG101 p.Arg209Cys Uncertain significance Single submitter
- ATG101 p.Arg32Cys Uncertain significance Single submitter
- ATG101 p.Arg77His Uncertain significance Single submitter
- ATG101 p.Ile153Val Uncertain significance Single submitter
- ATG101 p.Leu8Arg Uncertain significance Single submitter
- ATG101 p.Lys78Arg Uncertain significance Single submitter
- ATG101 p.Met21Leu Uncertain significance Single submitter
- ATG101 p.Met21Thr Uncertain significance Single submitter
- ATG101 p.Met98Val Uncertain significance Single submitter
- ATG101 p.Ser113Ala Uncertain significance Single submitter
- ATG101 p.Thr27Met Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- ATG101 p.Arg15Trp Uncertain significance Single submitter
- ATG101 p.Arg183Trp Uncertain significance Single submitter
- ATG101 p.Arg66His Uncertain significance Single submitter
- ATG101 p.Arg88Cys Uncertain significance Single submitter
- ATG101 p.Gln16Glu Uncertain significance Single submitter
- ATG101 p.Glu6Asp Uncertain significance Single submitter
- ATG101 p.Glu82Ala Uncertain significance Single submitter
- ATG101 p.Glu9Gln Uncertain significance Single submitter
- ATG101 p.Lys106Arg Uncertain significance Single submitter
- ATG101 p.Lys167Arg Uncertain significance Single submitter
- ATG101 p.Met159Leu Uncertain significance Single submitter
- ATG101 p.Phe62Leu Uncertain significance Single submitter
- ATG101 p.Thr133Met Uncertain significance Single submitter
- ATG101 p.Val50Met Uncertain significance Single submitter
- ATG101 p.Val7Gly Uncertain significance Single submitter
All ATG101 variants
Likely benign 1
- p.Leu8= Single submitter
Uncertain significance 29
- p.Ala130Ser Single submitter ⚠
- p.Arg109His Single submitter ⚠
- p.Arg15Trp Single submitter ⚠
- p.Arg183Gln Single submitter ⚠
- p.Arg183Trp Single submitter ⚠
- p.Arg209Cys Single submitter ⚠
- p.Arg32Cys Single submitter ⚠
- p.Arg66His Single submitter ⚠
- p.Arg77His Single submitter ⚠
- p.Arg88Cys Single submitter ⚠
- p.Gln16Glu Single submitter ⚠
- p.Glu6Asp Single submitter ⚠
- p.Glu82Ala Single submitter ⚠
- p.Glu9Gln Single submitter ⚠
- p.Ile153Val Single submitter ⚠
- p.Leu8Arg Single submitter ⚠
- p.Lys106Arg Single submitter ⚠
- p.Lys167Arg Single submitter ⚠
- p.Lys78Arg Single submitter ⚠
- p.Met159Leu Single submitter ⚠
- p.Met21Leu Single submitter ⚠
- p.Met21Thr Single submitter ⚠
- p.Met98Val Single submitter ⚠
- p.Phe62Leu Single submitter ⚠
- p.Ser113Ala Single submitter ⚠
- p.Thr133Met Single submitter ⚠
- p.Thr27Met Single submitter ⚠
- p.Val50Met Single submitter ⚠
- p.Val7Gly Single submitter ⚠