ATG14 — 72 ClinVar variants
All ClinVar germline ATG14 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 65 flagged for review →
4 Likely benign · 68 Uncertain significance
Full ATG14 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 65
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 60
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ATG14 p.Ala466Thr Uncertain significance Multiple submitters
- ATG14 p.Ala11Val Uncertain significance Single submitter
- ATG14 p.Ala228Gly Uncertain significance Single submitter
- ATG14 p.Ala306Val Uncertain significance Single submitter
- ATG14 p.Ala9Thr Uncertain significance Single submitter
- ATG14 p.Arg170Cys Uncertain significance Single submitter
- ATG14 p.Arg184Ile Uncertain significance Single submitter
- ATG14 p.Arg189His Uncertain significance Single submitter
- ATG14 p.Arg24Gln Uncertain significance Single submitter
- ATG14 p.Arg423Cys Uncertain significance Single submitter
- ATG14 p.Arg442Gln Uncertain significance Single submitter
- ATG14 p.Arg492His Uncertain significance Single submitter
- ATG14 p.Arg72Gly Uncertain significance Single submitter
- ATG14 p.Asn354Ile Uncertain significance Single submitter
- ATG14 p.Asp25Asn Uncertain significance Single submitter
- ATG14 p.Asp25Val Uncertain significance Single submitter
- ATG14 p.Asp28Gly Uncertain significance Single submitter
- ATG14 p.Asp421Asn Uncertain significance Single submitter
- ATG14 p.Cys330Phe Uncertain significance Single submitter
- ATG14 p.Gln370Lys Uncertain significance Single submitter
- ATG14 p.Glu209Lys Uncertain significance Single submitter
- ATG14 p.Glu224Gly Uncertain significance Single submitter
- ATG14 p.Glu403Gln Uncertain significance Single submitter
- ATG14 p.Glu427Lys Uncertain significance Single submitter
- ATG14 p.Gly130Glu Uncertain significance Single submitter
- ATG14 p.Gly173Arg Uncertain significance Single submitter
- ATG14 p.Gly18Glu Uncertain significance Single submitter
- ATG14 p.Gly18Trp Uncertain significance Single submitter
- ATG14 p.Gly6Arg Uncertain significance Single submitter
- ATG14 p.Gly8Arg Uncertain significance Single submitter
- ATG14 p.Ile181Val Uncertain significance Single submitter
- ATG14 p.Ile446Val Uncertain significance Single submitter
- ATG14 p.Leu123Phe Uncertain significance Single submitter
- ATG14 p.Leu85Val Uncertain significance Single submitter
- ATG14 p.Lys136Arg Uncertain significance Single submitter
- ATG14 p.Lys94Asn Uncertain significance Single submitter
- ATG14 p.Met100Val Uncertain significance Single submitter
- ATG14 p.Met118Leu Uncertain significance Single submitter
- ATG14 p.Met294Ile Uncertain significance Single submitter
- ATG14 p.Met294Val Uncertain significance Single submitter
- ATG14 p.Met379Leu Uncertain significance Single submitter
- ATG14 p.Pro15Arg Uncertain significance Single submitter
- ATG14 p.Pro218Leu Uncertain significance Single submitter
- ATG14 p.Pro21Leu Uncertain significance Single submitter
- ATG14 p.Pro4Ser Uncertain significance Single submitter
- ATG14 p.Ser115Phe Uncertain significance Single submitter
- ATG14 p.Ser281Ile Uncertain significance Single submitter
- ATG14 p.Ser416Pro Uncertain significance Single submitter
- ATG14 p.Ser5Arg Uncertain significance Single submitter
- ATG14 p.Ser61Gly Uncertain significance Single submitter
- ATG14 p.Ser83Asn Uncertain significance Single submitter
- ATG14 p.Ser87Ile Uncertain significance Single submitter
- ATG14 p.Thr106Ile Uncertain significance Single submitter
- ATG14 p.Thr126Ser Uncertain significance Single submitter
- ATG14 p.Thr213Ala Uncertain significance Single submitter
- ATG14 p.Thr489Ala Uncertain significance Single submitter
- ATG14 p.Tyr279Cys Uncertain significance Single submitter
- ATG14 p.Val424Gly Uncertain significance Single submitter
- ATG14 p.Val65Leu Uncertain significance Single submitter
- ATG14 p.Val96Ala Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All ATG14 variants
Likely benign 4
- p.Arg391= Single submitter
- p.Arg423His Single submitter
- p.Arg84Gln Single submitter
- p.Leu317= Single submitter
Uncertain significance 68
- p.Ala466Thr Multiple submitters ⚠
- p.Ala11Val Single submitter ⚠
- p.Ala228Gly Single submitter ⚠
- p.Ala306Val Single submitter ⚠
- p.Ala479Pro Single submitter ⚠
- p.Ala9Thr Single submitter ⚠
- p.Arg170Cys Single submitter ⚠
- p.Arg184Ile Single submitter ⚠
- p.Arg189His Single submitter ⚠
- p.Arg24Gln Single submitter ⚠
- p.Arg391Ser Single submitter ⚠
- p.Arg423Cys Single submitter ⚠
- p.Arg442Gln Single submitter ⚠
- p.Arg492His Single submitter ⚠
- p.Arg72Gly Single submitter ⚠
- p.Asn354Ile Single submitter ⚠
- p.Asp25Asn Single submitter ⚠
- p.Asp25Val Single submitter ⚠
- p.Asp28Gly Single submitter ⚠
- p.Asp421Asn Single submitter ⚠
- p.Cys330Phe Single submitter ⚠
- p.Gln370Lys Single submitter ⚠
- p.Glu209Lys Single submitter ⚠
- p.Glu224Gly Single submitter ⚠
- p.Glu403Gln Single submitter ⚠
- p.Glu427Lys Single submitter ⚠
- p.Gly130Glu Single submitter ⚠
- p.Gly173Arg Single submitter ⚠
- p.Gly18Glu Single submitter ⚠
- p.Gly18Trp Single submitter ⚠
- p.Gly432Asp Single submitter ⚠
- p.Gly6Arg Single submitter ⚠
- p.Gly8Arg Single submitter ⚠
- p.Ile181Val Single submitter ⚠
- p.Ile320Thr Single submitter
- p.Ile446Val Single submitter ⚠
- p.Leu123Phe Single submitter ⚠
- p.Leu36Pro Single submitter ⚠
- p.Leu85Val Single submitter ⚠
- p.Lys136Arg Single submitter ⚠
- p.Lys94Asn Single submitter ⚠
- p.Met100Val Single submitter ⚠
- p.Met118Leu Single submitter ⚠
- p.Met294Ile Single submitter ⚠
- p.Met294Val Single submitter ⚠
- p.Met379Leu Single submitter ⚠
- p.Phe407Ser Single submitter
- p.Pro15Arg Single submitter ⚠
- p.Pro218Leu Single submitter ⚠
- p.Pro21Leu Single submitter ⚠
- p.Pro299Ser Single submitter
- p.Pro4Ser Single submitter ⚠
- p.Ser115Phe Single submitter ⚠
- p.Ser281Ile Single submitter ⚠
- p.Ser304Gly Single submitter ⚠
- p.Ser416Pro Single submitter ⚠
- p.Ser5Arg Single submitter ⚠
- p.Ser61Gly Single submitter ⚠
- p.Ser83Asn Single submitter ⚠
- p.Ser87Ile Single submitter ⚠
- p.Thr106Ile Single submitter ⚠
- p.Thr126Ser Single submitter ⚠
- p.Thr213Ala Single submitter ⚠
- p.Thr489Ala Single submitter ⚠
- p.Tyr279Cys Single submitter ⚠
- p.Val424Gly Single submitter ⚠
- p.Val65Leu Single submitter ⚠
- p.Val96Ala Single submitter ⚠