ATG16L2 — 85 ClinVar variants
All ClinVar germline ATG16L2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 77 flagged for review →
1 Benign · 8 Likely benign · 76 Uncertain significance
Full ATG16L2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 77
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ATG16L2 p.Ala165Glu Uncertain significance Single submitter
- ATG16L2 p.Ala188Gly Uncertain significance Single submitter
- ATG16L2 p.Ala219Val Uncertain significance Single submitter
- ATG16L2 p.Ala277Pro Uncertain significance Single submitter
- ATG16L2 p.Arg13Cys Uncertain significance Single submitter
- ATG16L2 p.Arg250Gly Uncertain significance Single submitter
- ATG16L2 p.Arg323Gln Uncertain significance Single submitter
- ATG16L2 p.Arg442Cys Uncertain significance Single submitter
- ATG16L2 p.Arg442His Uncertain significance Single submitter
- ATG16L2 p.Arg444Gln Uncertain significance Single submitter
- ATG16L2 p.Arg90Ser Uncertain significance Single submitter
- ATG16L2 p.Asn461Ser Uncertain significance Single submitter
- ATG16L2 p.Asn524Ser Uncertain significance Single submitter
- ATG16L2 p.Cys267Arg Uncertain significance Single submitter
- ATG16L2 p.Gln152Arg Uncertain significance Single submitter
- ATG16L2 p.Gln405Arg Uncertain significance Single submitter
- ATG16L2 p.Gln70Arg Uncertain significance Single submitter
- ATG16L2 p.Gly410Glu Uncertain significance Single submitter
- ATG16L2 p.Gly452Ser Uncertain significance Single submitter
- ATG16L2 p.Gly603Arg Uncertain significance Single submitter
- ATG16L2 p.His335Tyr Uncertain significance Single submitter
- ATG16L2 p.His494Gln Uncertain significance Single submitter
- ATG16L2 p.His69Arg Uncertain significance Single submitter
- ATG16L2 p.Ile305Met Uncertain significance Single submitter
- ATG16L2 p.Ile305Thr Uncertain significance Single submitter
- ATG16L2 p.Ile476Phe Uncertain significance Single submitter
- ATG16L2 p.Leu195Pro Uncertain significance Single submitter
- ATG16L2 p.Leu208Val Uncertain significance Single submitter
- ATG16L2 p.Leu225Pro Uncertain significance Single submitter
- ATG16L2 p.Leu284Pro Uncertain significance Single submitter
- ATG16L2 p.Leu418Pro Uncertain significance Single submitter
- ATG16L2 p.Lys199Asn Uncertain significance Single submitter
- ATG16L2 p.Lys227Glu Uncertain significance Single submitter
- ATG16L2 p.Pro59Leu Uncertain significance Single submitter
- ATG16L2 p.Pro7Ala Uncertain significance Single submitter
- ATG16L2 p.Ser123Leu Uncertain significance Single submitter
- ATG16L2 p.Thr433Met Uncertain significance Single submitter
- ATG16L2 p.Thr579Ile Uncertain significance Single submitter
- ATG16L2 p.Val139Leu Uncertain significance Single submitter
- ATG16L2 p.Val174Leu Uncertain significance Single submitter
- ATG16L2 p.Val196Leu Uncertain significance Single submitter
- ATG16L2 p.Val505Ala Uncertain significance Single submitter
- ATG16L2 p.Val6Ala Uncertain significance Single submitter
Predictors split 34
The independent predictors disagree with each other — read with care.
- ATG16L2 p.Ala150Ser Uncertain significance Single submitter
- ATG16L2 p.Ala47Pro Uncertain significance Single submitter
- ATG16L2 p.Ala598Thr Uncertain significance Single submitter
- ATG16L2 p.Arg157Leu Uncertain significance Single submitter
- ATG16L2 p.Arg209His Uncertain significance Single submitter
- ATG16L2 p.Arg327Trp Uncertain significance Single submitter
- ATG16L2 p.Arg343Gly Uncertain significance Single submitter
- ATG16L2 p.Arg358His Uncertain significance Single submitter
- ATG16L2 p.Arg369His Uncertain significance Single submitter
- ATG16L2 p.Arg453Cys Uncertain significance Single submitter
- ATG16L2 p.Arg486Gln Uncertain significance Single submitter
- ATG16L2 p.Arg504Trp Uncertain significance Single submitter
- ATG16L2 p.Arg522Gln Uncertain significance Single submitter
- ATG16L2 p.Arg613Thr Uncertain significance Single submitter
- ATG16L2 p.Asp190Tyr Uncertain significance Single submitter
- ATG16L2 p.Asp543Asn Uncertain significance Single submitter
- ATG16L2 p.Cys568Tyr Likely benign Single submitter
- ATG16L2 p.Gln148Pro Uncertain significance Single submitter
- ATG16L2 p.Glu214Asp Uncertain significance Single submitter
- ATG16L2 p.Gly580Arg Uncertain significance Single submitter
- ATG16L2 p.Gly8Ser Uncertain significance Single submitter
- ATG16L2 p.Ile18Met Uncertain significance Single submitter
- ATG16L2 p.Ile485Met Uncertain significance Single submitter
- ATG16L2 p.Leu225Val Uncertain significance Single submitter
- ATG16L2 p.Leu282Arg Uncertain significance Single submitter
- ATG16L2 p.Leu43Arg Uncertain significance Single submitter
- ATG16L2 p.Leu43Val Uncertain significance Single submitter
- ATG16L2 p.Leu57Val Uncertain significance Single submitter
- ATG16L2 p.Lys227Thr Uncertain significance Single submitter
- ATG16L2 p.Pro317Arg Uncertain significance Single submitter
- ATG16L2 p.Thr283Met Uncertain significance Single submitter
- ATG16L2 p.Thr375Ile Uncertain significance Single submitter
- ATG16L2 p.Val597Met Uncertain significance Single submitter
- ATG16L2 p.Val87Phe Uncertain significance Single submitter
All ATG16L2 variants
Benign 1
- p.Cys319Ser Multiple submitters
Likely benign 8
- p.Ala88Thr Single submitter
- p.Arg143Gln Single submitter
- p.Arg491= Single submitter
- p.Cys568Tyr Single submitter ⚠
- p.Cys591= Single submitter
- p.Glu448= Single submitter
- p.His42Arg Single submitter
- p.Met606Val Single submitter
Uncertain significance 76
- p.Ala150Ser Single submitter ⚠
- p.Ala165Glu Single submitter ⚠
- p.Ala188Gly Single submitter ⚠
- p.Ala219Val Single submitter ⚠
- p.Ala277Pro Single submitter ⚠
- p.Ala47Pro Single submitter ⚠
- p.Ala598Thr Single submitter ⚠
- p.Arg13Cys Single submitter ⚠
- p.Arg157Leu Single submitter ⚠
- p.Arg209His Single submitter ⚠
- p.Arg250Gly Single submitter ⚠
- p.Arg323Gln Single submitter ⚠
- p.Arg327Trp Single submitter ⚠
- p.Arg343Gly Single submitter ⚠
- p.Arg358His Single submitter ⚠
- p.Arg369His Single submitter ⚠
- p.Arg442Cys Single submitter ⚠
- p.Arg442His Single submitter ⚠
- p.Arg444Gln Single submitter ⚠
- p.Arg453Cys Single submitter ⚠
- p.Arg486Gln Single submitter ⚠
- p.Arg504Trp Single submitter ⚠
- p.Arg522Gln Single submitter ⚠
- p.Arg613Thr Single submitter ⚠
- p.Arg90Ser Single submitter ⚠
- p.Asn461Ser Single submitter ⚠
- p.Asn524Ser Single submitter ⚠
- p.Asp190Tyr Single submitter ⚠
- p.Asp543Asn Single submitter ⚠
- p.Cys267Arg Single submitter ⚠
- p.Gln148Pro Single submitter ⚠
- p.Gln152Arg Single submitter ⚠
- p.Gln405Arg Single submitter ⚠
- p.Gln70Arg Single submitter ⚠
- p.Glu214Asp Single submitter ⚠
- p.Gly410Glu Single submitter ⚠
- p.Gly452Ser Single submitter ⚠
- p.Gly580Arg Single submitter ⚠
- p.Gly603Arg Single submitter ⚠
- p.Gly8Ser Single submitter ⚠
- p.His335Tyr Single submitter ⚠
- p.His494Gln Single submitter ⚠
- p.His69Arg Single submitter ⚠
- p.Ile18Met Single submitter ⚠
- p.Ile305Met Single submitter ⚠
- p.Ile305Thr Single submitter ⚠
- p.Ile476Phe Single submitter ⚠
- p.Ile485Met Single submitter ⚠
- p.Leu195Pro Single submitter ⚠
- p.Leu208Val Single submitter ⚠
- p.Leu225Pro Single submitter ⚠
- p.Leu225Val Single submitter ⚠
- p.Leu282Arg Single submitter ⚠
- p.Leu284Pro Single submitter ⚠
- p.Leu418Pro Single submitter ⚠
- p.Leu43Arg Single submitter ⚠
- p.Leu43Val Single submitter ⚠
- p.Leu57Val Single submitter ⚠
- p.Lys199Asn Single submitter ⚠
- p.Lys227Glu Single submitter ⚠
- p.Lys227Thr Single submitter ⚠
- p.Pro317Arg Single submitter ⚠
- p.Pro59Leu Single submitter ⚠
- p.Pro7Ala Single submitter ⚠
- p.Ser123Leu Single submitter ⚠
- p.Thr283Met Single submitter ⚠
- p.Thr375Ile Single submitter ⚠
- p.Thr433Met Single submitter ⚠
- p.Thr579Ile Single submitter ⚠
- p.Val139Leu Single submitter ⚠
- p.Val174Leu Single submitter ⚠
- p.Val196Leu Single submitter ⚠
- p.Val505Ala Single submitter ⚠
- p.Val597Met Single submitter ⚠
- p.Val6Ala Single submitter ⚠
- p.Val87Phe Single submitter ⚠