ATG3 — 31 ClinVar variants
All ClinVar germline ATG3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
31 Uncertain significance
Full ATG3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ATG3 p.Ala299Thr Uncertain significance Single submitter
- ATG3 p.Ala65Thr Uncertain significance Single submitter
- ATG3 p.Ala96Thr Uncertain significance Single submitter
- ATG3 p.Arg84Trp Uncertain significance Single submitter
- ATG3 p.Asp101Glu Uncertain significance Single submitter
- ATG3 p.Asp174Asn Uncertain significance Single submitter
- ATG3 p.Asp307Gly Uncertain significance Single submitter
- ATG3 p.Asp307Val Uncertain significance Single submitter
- ATG3 p.Cys182Tyr Uncertain significance Single submitter
- ATG3 p.Gln225Leu Uncertain significance Single submitter
- ATG3 p.Gln72Arg Uncertain significance Single submitter
- ATG3 p.Glu146Val Uncertain significance Single submitter
- ATG3 p.Glu170Lys Uncertain significance Single submitter
- ATG3 p.Glu268Asp Uncertain significance Single submitter
- ATG3 p.Glu95Gly Uncertain significance Single submitter
- ATG3 p.Ile116Val Uncertain significance Single submitter
- ATG3 p.Phe312Ser Uncertain significance Single submitter
- ATG3 p.Pro251Thr Uncertain significance Single submitter
- ATG3 p.Pro257Ala Uncertain significance Single submitter
- ATG3 p.Pro68Leu Uncertain significance Single submitter
- ATG3 p.Pro80Leu Uncertain significance Single submitter
- ATG3 p.Thr110Lys Uncertain significance Single submitter
- ATG3 p.Thr20Ile Uncertain significance Single submitter
- ATG3 p.Trp53Arg Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All ATG3 variants
Uncertain significance 31
- p.Ala299Thr Single submitter ⚠
- p.Ala65Thr Single submitter ⚠
- p.Ala96Thr Single submitter ⚠
- p.Arg84Trp Single submitter ⚠
- p.Asp101Glu Single submitter ⚠
- p.Asp174Asn Single submitter ⚠
- p.Asp174Val Single submitter
- p.Asp307Gly Single submitter ⚠
- p.Asp307Val Single submitter ⚠
- p.Cys182Tyr Single submitter ⚠
- p.Gln225Leu Single submitter ⚠
- p.Gln72Arg Single submitter ⚠
- p.Glu146Val Single submitter ⚠
- p.Glu170Lys Single submitter ⚠
- p.Glu268Asp Single submitter ⚠
- p.Glu279Ala Single submitter ⚠
- p.Glu95Gly Single submitter ⚠
- p.Ile116Val Single submitter ⚠
- p.Ile247Thr Single submitter
- p.Ile301Val Single submitter ⚠
- p.Met232Val Single submitter ⚠
- p.Phe312Ser Single submitter ⚠
- p.Pro251Thr Single submitter ⚠
- p.Pro257Ala Single submitter ⚠
- p.Pro68Leu Single submitter ⚠
- p.Pro80Leu Single submitter ⚠
- p.Thr110Lys Single submitter ⚠
- p.Thr20Ile Single submitter ⚠
- p.Trp53Arg Single submitter ⚠
- p.Tyr66His Single submitter ⚠
- p.Val179Gly Single submitter ⚠