ATG4C — 68 ClinVar variants
All ClinVar germline ATG4C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 67 flagged for review →
1 Likely benign · 67 Uncertain significance
Full ATG4C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 67
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 50
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ATG4C p.Arg376Gln Uncertain significance Single submitter
- ATG4C p.Arg86Gly Uncertain significance Single submitter
- ATG4C p.Arg92Gly Uncertain significance Single submitter
- ATG4C p.Arg92Lys Uncertain significance Single submitter
- ATG4C p.Asn193Ser Uncertain significance Single submitter
- ATG4C p.Asn268Asp Uncertain significance Single submitter
- ATG4C p.Asn268Ile Uncertain significance Single submitter
- ATG4C p.Asn434Asp Uncertain significance Single submitter
- ATG4C p.Asn434Ser Uncertain significance Single submitter
- ATG4C p.Asp137Glu Uncertain significance Single submitter
- ATG4C p.Asp206Val Uncertain significance Single submitter
- ATG4C p.Asp282Asn Uncertain significance Single submitter
- ATG4C p.Asp286Asn Uncertain significance Single submitter
- ATG4C p.Asp379Gly Uncertain significance Single submitter
- ATG4C p.Cys111Arg Uncertain significance Single submitter
- ATG4C p.Cys382Ser Uncertain significance Single submitter
- ATG4C p.Cys47Arg Uncertain significance Single submitter
- ATG4C p.Gln117His Uncertain significance Single submitter
- ATG4C p.Gln122Arg Uncertain significance Single submitter
- ATG4C p.Gly385Arg Uncertain significance Single submitter
- ATG4C p.His197Leu Uncertain significance Single submitter
- ATG4C p.His49Pro Uncertain significance Single submitter
- ATG4C p.His70Tyr Uncertain significance Single submitter
- ATG4C p.Ile176Val Uncertain significance Single submitter
- ATG4C p.Ile240Val Uncertain significance Single submitter
- ATG4C p.Ile258Val Uncertain significance Single submitter
- ATG4C p.Ile384Leu Uncertain significance Single submitter
- ATG4C p.Ile67Val Uncertain significance Single submitter
- ATG4C p.Ile98Met Uncertain significance Single submitter
- ATG4C p.Leu44Ile Uncertain significance Single submitter
- ATG4C p.Lys199Arg Uncertain significance Single submitter
- ATG4C p.Lys226Glu Uncertain significance Single submitter
- ATG4C p.Lys406Gln Uncertain significance Single submitter
- ATG4C p.Lys444Arg Uncertain significance Single submitter
- ATG4C p.Phe79Leu Uncertain significance Single submitter
- ATG4C p.Pro327Arg Uncertain significance Single submitter
- ATG4C p.Pro346Leu Uncertain significance Single submitter
- ATG4C p.Pro346Thr Uncertain significance Single submitter
- ATG4C p.Pro60Ser Uncertain significance Single submitter
- ATG4C p.Ser451Asn Uncertain significance Single submitter
- ATG4C p.Thr175Pro Uncertain significance Single submitter
- ATG4C p.Thr33Arg Uncertain significance Single submitter
- ATG4C p.Trp149Ser Uncertain significance Single submitter
- ATG4C p.Trp203Arg Uncertain significance Single submitter
- ATG4C p.Tyr25Asp Uncertain significance Single submitter
- ATG4C p.Tyr25Cys Uncertain significance Single submitter
- ATG4C p.Tyr306Cys Uncertain significance Single submitter
- ATG4C p.Val237Phe Uncertain significance Single submitter
- ATG4C p.Val355Ile Uncertain significance Single submitter
- ATG4C p.Val9Ile Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- ATG4C p.Arg80Cys Uncertain significance Single submitter
- ATG4C p.Asn75Ile Uncertain significance Single submitter
- ATG4C p.Asp359Tyr Uncertain significance Single submitter
- ATG4C p.Asp393Gly Uncertain significance Single submitter
- ATG4C p.Glu219Asp Uncertain significance Single submitter
- ATG4C p.Gly116Ser Uncertain significance Single submitter
- ATG4C p.Gly130Asp Uncertain significance Single submitter
- ATG4C p.Gly312Val Uncertain significance Single submitter
- ATG4C p.Ile218Thr Uncertain significance Single submitter
- ATG4C p.Ile98Thr Uncertain significance Single submitter
- ATG4C p.Leu129Val Uncertain significance Single submitter
- ATG4C p.Lys222Met Uncertain significance Single submitter
- ATG4C p.Pro361Ser Uncertain significance Single submitter
- ATG4C p.Ser207Phe Uncertain significance Single submitter
- ATG4C p.Ser451Ile Uncertain significance Single submitter
- ATG4C p.Thr112Ile Uncertain significance Single submitter
- ATG4C p.Trp149Cys Uncertain significance Single submitter
All ATG4C variants
Likely benign 1
- p.Thr175Lys Single submitter
Uncertain significance 67
- p.Arg376Gln Single submitter ⚠
- p.Arg80Cys Single submitter ⚠
- p.Arg86Gly Single submitter ⚠
- p.Arg92Gly Single submitter ⚠
- p.Arg92Lys Single submitter ⚠
- p.Asn193Ser Single submitter ⚠
- p.Asn268Asp Single submitter ⚠
- p.Asn268Ile Single submitter ⚠
- p.Asn434Asp Single submitter ⚠
- p.Asn434Ser Single submitter ⚠
- p.Asn75Ile Single submitter ⚠
- p.Asp137Glu Single submitter ⚠
- p.Asp206Val Single submitter ⚠
- p.Asp282Asn Single submitter ⚠
- p.Asp286Asn Single submitter ⚠
- p.Asp359Tyr Single submitter ⚠
- p.Asp379Gly Single submitter ⚠
- p.Asp393Gly Single submitter ⚠
- p.Cys111Arg Single submitter ⚠
- p.Cys382Ser Single submitter ⚠
- p.Cys47Arg Single submitter ⚠
- p.Gln117His Single submitter ⚠
- p.Gln122Arg Single submitter ⚠
- p.Glu219Asp Single submitter ⚠
- p.Gly116Ser Single submitter ⚠
- p.Gly130Asp Single submitter ⚠
- p.Gly312Val Single submitter ⚠
- p.Gly385Arg Single submitter ⚠
- p.His197Leu Single submitter ⚠
- p.His49Pro Single submitter ⚠
- p.His70Tyr Single submitter ⚠
- p.Ile176Val Single submitter ⚠
- p.Ile218Thr Single submitter ⚠
- p.Ile240Val Single submitter ⚠
- p.Ile258Val Single submitter ⚠
- p.Ile384Leu Single submitter ⚠
- p.Ile67Val Single submitter ⚠
- p.Ile98Met Single submitter ⚠
- p.Ile98Thr Single submitter ⚠
- p.Leu129Val Single submitter ⚠
- p.Leu44Ile Single submitter ⚠
- p.Lys199Arg Single submitter ⚠
- p.Lys222Met Single submitter ⚠
- p.Lys226Glu Single submitter ⚠
- p.Lys406Gln Single submitter ⚠
- p.Lys444Arg Single submitter ⚠
- p.Phe79Leu Single submitter ⚠
- p.Pro327Arg Single submitter ⚠
- p.Pro346Leu Single submitter ⚠
- p.Pro346Thr Single submitter ⚠
- p.Pro361Ser Single submitter ⚠
- p.Pro60Ser Single submitter ⚠
- p.Ser207Phe Single submitter ⚠
- p.Ser451Asn Single submitter ⚠
- p.Ser451Ile Single submitter ⚠
- p.Thr112Ile Single submitter ⚠
- p.Thr175Pro Single submitter ⚠
- p.Thr33Arg Single submitter ⚠
- p.Trp149Cys Single submitter ⚠
- p.Trp149Ser Single submitter ⚠
- p.Trp203Arg Single submitter ⚠
- p.Tyr25Asp Single submitter ⚠
- p.Tyr25Cys Single submitter ⚠
- p.Tyr306Cys Single submitter ⚠
- p.Val237Phe Single submitter ⚠
- p.Val355Ile Single submitter ⚠
- p.Val9Ile Single submitter ⚠