ATL2 — 86 ClinVar variants

All ClinVar germline ATL2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 83 flagged for review →

1 Benign · 2 Likely benign · 83 Uncertain significance

Full ATL2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 83

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 42

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 41

The independent predictors disagree with each other — read with care.

All ATL2 variants

Benign 1

p.Gly365= Multiple submitters

Likely benign 2

p.Arg322Gln Single submitter
p.Thr393Ile Single submitter

Uncertain significance 83

p.Ala100Val Single submitter ⚠
p.Ala227Gly Single submitter ⚠
p.Ala28Gly Single submitter ⚠
p.Ala2Val Single submitter ⚠
p.Ala388Ser Single submitter ⚠
p.Ala388Val Single submitter ⚠
p.Ala425Val Single submitter ⚠
p.Ala578Val Single submitter ⚠
p.Arg161Thr Single submitter ⚠
p.Arg20Trp Single submitter ⚠
p.Arg21Pro Single submitter ⚠
p.Arg22Gln Single submitter ⚠
p.Arg325Gln Single submitter ⚠
p.Arg325Gly Single submitter ⚠
p.Arg416Gln Single submitter ⚠
p.Arg416Pro Single submitter ⚠
p.Arg430His Single submitter ⚠
p.Arg442His Single submitter ⚠
p.Asn154Ser Single submitter ⚠
p.Asn290His Single submitter ⚠
p.Asn31His Single submitter ⚠
p.Asp319Val Single submitter ⚠
p.Asp405Glu Single submitter ⚠
p.Asp551Val Single submitter ⚠
p.Asp5Asn Single submitter ⚠
p.Asp69His Single submitter ⚠
p.Asp91Gly Single submitter ⚠
p.Cys441Ser Single submitter ⚠
p.Gln11Glu Single submitter ⚠
p.Gln181Arg Single submitter ⚠
p.Gln218Glu Single submitter ⚠
p.Gln218Leu Single submitter ⚠
p.Gln536Arg Single submitter ⚠
p.Glu230Asp Single submitter ⚠
p.Glu323Asp Single submitter ⚠
p.Glu339Gly Single submitter ⚠
p.Glu341Gln Single submitter ⚠
p.Glu41Asp Single submitter ⚠
p.Glu449Lys Single submitter ⚠
p.Glu526Lys Single submitter ⚠
p.Glu6Lys Single submitter ⚠
p.Glu78Ala Single submitter ⚠
p.Gly16Ala Single submitter ⚠
p.Gly509Ala Single submitter ⚠
p.His14Gln Single submitter ⚠
p.His370Asn Single submitter ⚠
p.Ile184Met Single submitter ⚠
p.Ile426Thr Single submitter ⚠
p.Ile566Phe Single submitter ⚠
p.Leu17Met Single submitter ⚠
p.Leu291Ile Single submitter ⚠
p.Leu497Val Single submitter ⚠
p.Leu503Phe Single submitter ⚠
p.Leu503Val Single submitter ⚠
p.Leu553Phe Single submitter ⚠
p.Lys105Glu Single submitter ⚠
p.Lys166Glu Single submitter ⚠
p.Lys581Asn Single submitter ⚠
p.Met118Ile Single submitter ⚠
p.Phe459Val Single submitter ⚠
p.Pro13Ala Single submitter ⚠
p.Pro334Ser Single submitter ⚠
p.Pro548Ser Single submitter ⚠
p.Ser253Ala Single submitter ⚠
p.Ser27Asn Single submitter ⚠
p.Ser308Gly Single submitter ⚠
p.Ser345Cys Single submitter ⚠
p.Ser34Leu Single submitter ⚠
p.Ser35Pro Single submitter ⚠
p.Ser565Cys Single submitter ⚠
p.Thr138Ala Single submitter ⚠
p.Thr305Ala Single submitter ⚠
p.Thr37Ile Single submitter ⚠
p.Thr455Ile Single submitter ⚠
p.Thr477Ala Single submitter ⚠
p.Thr571Ile Single submitter ⚠
p.Tyr248Phe Single submitter ⚠
p.Tyr444His Single submitter ⚠
p.Tyr456Cys Single submitter ⚠
p.Tyr470Cys Single submitter ⚠
p.Tyr470His Single submitter ⚠
p.Val169Met Single submitter ⚠
p.Val96Leu Single submitter ⚠