ATMIN — 146 ClinVar variants
All ClinVar germline ATMIN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 140 flagged for review →
9 Likely benign · 137 Uncertain significance
Full ATMIN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 140
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 94
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ATMIN p.Ala19Gly Uncertain significance Single submitter
- ATMIN p.Ala302Val Uncertain significance Single submitter
- ATMIN p.Ala340Thr Uncertain significance Single submitter
- ATMIN p.Ala359Thr Uncertain significance Single submitter
- ATMIN p.Ala3Gly Uncertain significance Single submitter
- ATMIN p.Ala431Thr Uncertain significance Single submitter
- ATMIN p.Ala52Pro Uncertain significance Single submitter
- ATMIN p.Ala539Thr Uncertain significance Single submitter
- ATMIN p.Ala54Thr Uncertain significance Single submitter
- ATMIN p.Ala59Pro Uncertain significance Single submitter
- ATMIN p.Ala62Val Uncertain significance Single submitter
- ATMIN p.Ala6Gly Uncertain significance Single submitter
- ATMIN p.Ala753Thr Uncertain significance Single submitter
- ATMIN p.Ala815Val Uncertain significance Single submitter
- ATMIN p.Arg254Gly Uncertain significance Single submitter
- ATMIN p.Asn102Ser Uncertain significance Single submitter
- ATMIN p.Asn172Ser Uncertain significance Single submitter
- ATMIN p.Asn249Asp Uncertain significance Single submitter
- ATMIN p.Asn412Ser Uncertain significance Single submitter
- ATMIN p.Asn531Thr Uncertain significance Single submitter
- ATMIN p.Asn556His Uncertain significance Single submitter
- ATMIN p.Asn750Ser Uncertain significance Single submitter
- ATMIN p.Asn761Thr Uncertain significance Single submitter
- ATMIN p.Asn822Ile Uncertain significance Single submitter
- ATMIN p.Asn822Lys Uncertain significance Single submitter
- ATMIN p.Asp222Val Uncertain significance Single submitter
- ATMIN p.Asp790His Uncertain significance Single submitter
- ATMIN p.Cys195Arg Uncertain significance Single submitter
- ATMIN p.Cys195Gly Uncertain significance Single submitter
- ATMIN p.Cys514Tyr Uncertain significance Single submitter
- ATMIN p.Cys688Tyr Uncertain significance Single submitter
- ATMIN p.Gln429Arg Uncertain significance Single submitter
- ATMIN p.Gln507Glu Uncertain significance Single submitter
- ATMIN p.Gln70Leu Uncertain significance Single submitter
- ATMIN p.Glu215Lys Uncertain significance Single submitter
- ATMIN p.Glu364Asp Uncertain significance Single submitter
- ATMIN p.Glu398Asp Uncertain significance Single submitter
- ATMIN p.Glu499Lys Uncertain significance Single submitter
- ATMIN p.Glu662Lys Uncertain significance Single submitter
- ATMIN p.Gly331Asp Uncertain significance Single submitter
- ATMIN p.Gly354Ala Uncertain significance Single submitter
- ATMIN p.Gly354Ser Uncertain significance Single submitter
- ATMIN p.Gly46Val Uncertain significance Single submitter
- ATMIN p.Gly515Ala Uncertain significance Single submitter
- ATMIN p.Gly515Arg Uncertain significance Single submitter
- ATMIN p.His165Arg Uncertain significance Single submitter
- ATMIN p.His183Tyr Uncertain significance Single submitter
- ATMIN p.His544Arg Uncertain significance Single submitter
- ATMIN p.His717Gln Uncertain significance Single submitter
- ATMIN p.His717Tyr Uncertain significance Single submitter
- ATMIN p.Ile115Met Uncertain significance Single submitter
- ATMIN p.Ile244Val Uncertain significance Single submitter
- ATMIN p.Ile375Leu Uncertain significance Single submitter
- ATMIN p.Ile565Val Uncertain significance Single submitter
- ATMIN p.Ile566Thr Uncertain significance Single submitter
- ATMIN p.Ile638Met Uncertain significance Single submitter
- ATMIN p.Leu15Pro Uncertain significance Single submitter
- ATMIN p.Leu247Ser Uncertain significance Single submitter
- ATMIN p.Leu351Met Uncertain significance Single submitter
- ATMIN p.Leu537Ser Uncertain significance Single submitter
- ATMIN p.Leu656Pro Uncertain significance Single submitter
- ATMIN p.Lys169Arg Uncertain significance Single submitter
- ATMIN p.Lys390Arg Uncertain significance Single submitter
- ATMIN p.Met309Val Uncertain significance Single submitter
- ATMIN p.Met513Lys Uncertain significance Single submitter
- ATMIN p.Met789Val Uncertain significance Single submitter
- ATMIN p.Phe568Val Uncertain significance Single submitter
- ATMIN p.Pro23Ser Uncertain significance Single submitter
- ATMIN p.Pro287Ala Uncertain significance Single submitter
- ATMIN p.Pro36Leu Uncertain significance Single submitter
- ATMIN p.Pro42Ser Uncertain significance Single submitter
- ATMIN p.Pro618Ala Uncertain significance Single submitter
- ATMIN p.Pro817Gln Uncertain significance Single submitter
- ATMIN p.Ser168Thr Uncertain significance Single submitter
- ATMIN p.Ser407Asn Uncertain significance Single submitter
- ATMIN p.Ser435Ala Uncertain significance Single submitter
- ATMIN p.Ser441Thr Uncertain significance Single submitter
- ATMIN p.Ser569Gly Uncertain significance Single submitter
- ATMIN p.Ser573Thr Uncertain significance Single submitter
- ATMIN p.Ser685Pro Uncertain significance Single submitter
- ATMIN p.Ser728Gly Uncertain significance Single submitter
- ATMIN p.Ser728Thr Uncertain significance Single submitter
- ATMIN p.Ser732Arg Uncertain significance Single submitter
- ATMIN p.Thr350Asn Uncertain significance Single submitter
- ATMIN p.Thr382Ile Uncertain significance Single submitter
- ATMIN p.Thr461Ile Uncertain significance Single submitter
- ATMIN p.Thr502Ala Uncertain significance Single submitter
- ATMIN p.Thr55Ala Uncertain significance Single submitter
- ATMIN p.Thr681Asn Uncertain significance Single submitter
- ATMIN p.Tyr419Cys Uncertain significance Single submitter
- ATMIN p.Tyr525Cys Uncertain significance Single submitter
- ATMIN p.Val301Leu Uncertain significance Single submitter
- ATMIN p.Val304Leu Uncertain significance Single submitter
- ATMIN p.Val316Ile Uncertain significance Single submitter
Predictors split 46
The independent predictors disagree with each other — read with care.
- ATMIN p.Ala10Glu Uncertain significance Single submitter
- ATMIN p.Ala16Val Uncertain significance Single submitter
- ATMIN p.Ala24Val Likely benign Single submitter
- ATMIN p.Ala8Glu Uncertain significance Single submitter
- ATMIN p.Ala8Val Uncertain significance Single submitter
- ATMIN p.Ala9Val Uncertain significance Single submitter
- ATMIN p.Arg48Gln Uncertain significance Single submitter
- ATMIN p.Asn556Tyr Uncertain significance Single submitter
- ATMIN p.Asp416Asn Uncertain significance Single submitter
- ATMIN p.Asp516Tyr Uncertain significance Single submitter
- ATMIN p.Asp635Tyr Uncertain significance Single submitter
- ATMIN p.Gln414His Uncertain significance Single submitter
- ATMIN p.Gly114Asp Uncertain significance Single submitter
- ATMIN p.Gly66Arg Likely benign Single submitter
- ATMIN p.Gly771Arg Uncertain significance Single submitter
- ATMIN p.Leu797Val Uncertain significance Single submitter
- ATMIN p.Lys300Ile Uncertain significance Single submitter
- ATMIN p.Phe130Val Uncertain significance Single submitter
- ATMIN p.Phe694Leu Uncertain significance Single submitter
- ATMIN p.Pro23Leu Uncertain significance Single submitter
- ATMIN p.Pro345Ser Uncertain significance Single submitter
- ATMIN p.Pro58Thr Uncertain significance Single submitter
- ATMIN p.Pro96Ser Uncertain significance Single submitter
- ATMIN p.Pro99Ala Uncertain significance Single submitter
- ATMIN p.Pro99Ser Uncertain significance Single submitter
- ATMIN p.Ser168Ile Uncertain significance Single submitter
- ATMIN p.Ser173Leu Uncertain significance Single submitter
- ATMIN p.Ser347Leu Uncertain significance Single submitter
- ATMIN p.Ser446Pro Uncertain significance Single submitter
- ATMIN p.Ser520Arg Uncertain significance Single submitter
- ATMIN p.Ser534Arg Uncertain significance Single submitter
- ATMIN p.Ser714Cys Uncertain significance Single submitter
- ATMIN p.Ser727Tyr Uncertain significance Single submitter
- ATMIN p.Ser74Asn Uncertain significance Single submitter
- ATMIN p.Ser814Cys Likely benign Single submitter
- ATMIN p.Thr402Met Uncertain significance Single submitter
- ATMIN p.Thr443Ala Uncertain significance Single submitter
- ATMIN p.Thr461Ala Uncertain significance Single submitter
- ATMIN p.Thr529Ile Uncertain significance Single submitter
- ATMIN p.Thr740Ser Uncertain significance Single submitter
- ATMIN p.Val106Leu Uncertain significance Single submitter
- ATMIN p.Val152Ile Uncertain significance Single submitter
- ATMIN p.Val308Met Uncertain significance Single submitter
- ATMIN p.Val318Glu Uncertain significance Single submitter
- ATMIN p.Val341Met Uncertain significance Single submitter
- ATMIN p.Val413Met Uncertain significance Single submitter
All ATMIN variants
Likely benign 9
- p.Ala24Val Single submitter ⚠
- p.Arg192Gln Single submitter
- p.Asn241Ser Single submitter
- p.Gly66Arg Single submitter ⚠
- p.Gly721Val Single submitter
- p.Ile380Val Single submitter
- p.Ser814Cys Single submitter ⚠
- p.Thr87= Single submitter
- p.Val731Met Single submitter
Uncertain significance 137
- p.Ala10Glu Single submitter ⚠
- p.Ala16Val Single submitter ⚠
- p.Ala19Gly Single submitter ⚠
- p.Ala302Val Single submitter ⚠
- p.Ala340Thr Single submitter ⚠
- p.Ala359Thr Single submitter ⚠
- p.Ala3Gly Single submitter ⚠
- p.Ala431Thr Single submitter ⚠
- p.Ala52Pro Single submitter ⚠
- p.Ala539Thr Single submitter ⚠
- p.Ala54Thr Single submitter ⚠
- p.Ala59Pro Single submitter ⚠
- p.Ala62Val Single submitter ⚠
- p.Ala6Gly Single submitter ⚠
- p.Ala753Thr Single submitter ⚠
- p.Ala815Val Single submitter ⚠
- p.Ala8Glu Single submitter ⚠
- p.Ala8Val Single submitter ⚠
- p.Ala9Val Single submitter ⚠
- p.Arg254Gly Single submitter ⚠
- p.Arg48Gln Single submitter ⚠
- p.Asn102Ser Single submitter ⚠
- p.Asn172Ser Single submitter ⚠
- p.Asn249Asp Single submitter ⚠
- p.Asn412Ser Single submitter ⚠
- p.Asn531Thr Single submitter ⚠
- p.Asn556His Single submitter ⚠
- p.Asn556Tyr Single submitter ⚠
- p.Asn750Ser Single submitter ⚠
- p.Asn761Thr Single submitter ⚠
- p.Asn822Ile Single submitter ⚠
- p.Asn822Lys Single submitter ⚠
- p.Asp222Val Single submitter ⚠
- p.Asp416Asn Single submitter ⚠
- p.Asp516Tyr Single submitter ⚠
- p.Asp635Tyr Single submitter ⚠
- p.Asp790His Single submitter ⚠
- p.Cys195Arg Single submitter ⚠
- p.Cys195Gly Single submitter ⚠
- p.Cys514Tyr Single submitter ⚠
- p.Cys688Tyr Single submitter ⚠
- p.Gln414His Single submitter ⚠
- p.Gln429Arg Single submitter ⚠
- p.Gln507Glu Single submitter ⚠
- p.Gln70Leu Single submitter ⚠
- p.Glu215Lys Single submitter ⚠
- p.Glu364Asp Single submitter ⚠
- p.Glu398Asp Single submitter ⚠
- p.Glu499Lys Single submitter ⚠
- p.Glu662Lys Single submitter ⚠
- p.Gly114Asp Single submitter ⚠
- p.Gly331Asp Single submitter ⚠
- p.Gly354Ala Single submitter ⚠
- p.Gly354Ser Single submitter ⚠
- p.Gly46Val Single submitter ⚠
- p.Gly515Ala Single submitter ⚠
- p.Gly515Arg Single submitter ⚠
- p.Gly771Arg Single submitter ⚠
- p.His165Arg Single submitter ⚠
- p.His183Tyr Single submitter ⚠
- p.His544Arg Single submitter ⚠
- p.His717Gln Single submitter ⚠
- p.His717Tyr Single submitter ⚠
- p.Ile115Met Single submitter ⚠
- p.Ile244Val Single submitter ⚠
- p.Ile375Leu Single submitter ⚠
- p.Ile565Val Single submitter ⚠
- p.Ile566Thr Single submitter ⚠
- p.Ile638Met Single submitter ⚠
- p.Leu15Pro Single submitter ⚠
- p.Leu247Ser Single submitter ⚠
- p.Leu351Met Single submitter ⚠
- p.Leu537Ser Single submitter ⚠
- p.Leu656Pro Single submitter ⚠
- p.Leu797Val Single submitter ⚠
- p.Lys169Arg Single submitter ⚠
- p.Lys300Ile Single submitter ⚠
- p.Lys390Arg Single submitter ⚠
- p.Met309Val Single submitter ⚠
- p.Met513Lys Single submitter ⚠
- p.Met789Val Single submitter ⚠
- p.Phe130Val Single submitter ⚠
- p.Phe568Val Single submitter ⚠
- p.Phe694Leu Single submitter ⚠
- p.Pro23Leu Single submitter ⚠
- p.Pro23Ser Single submitter ⚠
- p.Pro287Ala Single submitter ⚠
- p.Pro345Ser Single submitter ⚠
- p.Pro36Leu Single submitter ⚠
- p.Pro42Ser Single submitter ⚠
- p.Pro58Thr Single submitter ⚠
- p.Pro618Ala Single submitter ⚠
- p.Pro817Gln Single submitter ⚠
- p.Pro96Ser Single submitter ⚠
- p.Pro99Ala Single submitter ⚠
- p.Pro99Ser Single submitter ⚠
- p.Ser168Ile Single submitter ⚠
- p.Ser168Thr Single submitter ⚠
- p.Ser173Leu Single submitter ⚠
- p.Ser347Leu Single submitter ⚠
- p.Ser407Asn Single submitter ⚠
- p.Ser435Ala Single submitter ⚠
- p.Ser441Thr Single submitter ⚠
- p.Ser446Pro Single submitter ⚠
- p.Ser520Arg Single submitter ⚠
- p.Ser534Arg Single submitter ⚠
- p.Ser569Gly Single submitter ⚠
- p.Ser573Thr Single submitter ⚠
- p.Ser685Pro Single submitter ⚠
- p.Ser714Cys Single submitter ⚠
- p.Ser727Tyr Single submitter ⚠
- p.Ser728Gly Single submitter ⚠
- p.Ser728Thr Single submitter ⚠
- p.Ser732Arg Single submitter ⚠
- p.Ser74Asn Single submitter ⚠
- p.Thr350Asn Single submitter ⚠
- p.Thr382Ile Single submitter ⚠
- p.Thr402Met Single submitter ⚠
- p.Thr443Ala Single submitter ⚠
- p.Thr461Ala Single submitter ⚠
- p.Thr461Ile Single submitter ⚠
- p.Thr502Ala Single submitter ⚠
- p.Thr529Ile Single submitter ⚠
- p.Thr55Ala Single submitter ⚠
- p.Thr681Asn Single submitter ⚠
- p.Thr740Ser Single submitter ⚠
- p.Tyr419Cys Single submitter ⚠
- p.Tyr525Cys Single submitter ⚠
- p.Val106Leu Single submitter ⚠
- p.Val152Ile Single submitter ⚠
- p.Val301Leu Single submitter ⚠
- p.Val304Leu Single submitter ⚠
- p.Val308Met Single submitter ⚠
- p.Val316Ile Single submitter ⚠
- p.Val318Glu Single submitter ⚠
- p.Val341Met Single submitter ⚠
- p.Val413Met Single submitter ⚠