ATOH8 — 60 ClinVar variants
All ClinVar germline ATOH8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 55 flagged for review →
2 Likely benign · 58 Uncertain significance
Full ATOH8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 55
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 47
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ATOH8 p.Pro169Arg Uncertain significance Multiple submitters
-
ATOH8 p.Tyr40Cys
Uncertain significance
Multiple submitters
congenital portosystemic shunt
- ATOH8 p.Ala101Thr Uncertain significance Single submitter
-
ATOH8 p.Ala107Val
Uncertain significance
Single submitter
congenital portosystemic shunt
- ATOH8 p.Ala113Val Uncertain significance Single submitter
- ATOH8 p.Ala131Val Uncertain significance Single submitter
- ATOH8 p.Ala142Gly Uncertain significance Single submitter
- ATOH8 p.Ala170Thr Uncertain significance Single submitter
- ATOH8 p.Ala49Gly Uncertain significance Single submitter
- ATOH8 p.Ala81Gly Uncertain significance Single submitter
- ATOH8 p.Ala81Thr Uncertain significance Single submitter
- ATOH8 p.Ala93Val Uncertain significance Single submitter
- ATOH8 p.Arg308Leu Uncertain significance Single submitter
- ATOH8 p.Arg319His Uncertain significance Single submitter
- ATOH8 p.Arg319Leu Uncertain significance Single submitter
- ATOH8 p.Arg35Gly Uncertain significance Single submitter
- ATOH8 p.Arg63Ser Uncertain significance Single submitter
- ATOH8 p.Arg96Cys Uncertain significance Single submitter
- ATOH8 p.Cys111Arg Uncertain significance Single submitter
- ATOH8 p.Glu103Gln Uncertain significance Single submitter
- ATOH8 p.Glu141Ala Uncertain significance Single submitter
- ATOH8 p.Glu251Gln Uncertain significance Single submitter
- ATOH8 p.Gly120Glu Uncertain significance Single submitter
- ATOH8 p.Gly88Arg Uncertain significance Single submitter
- ATOH8 p.Gly88Val Uncertain significance Single submitter
- ATOH8 p.Gly89Arg Uncertain significance Single submitter
- ATOH8 p.Gly89Cys Uncertain significance Single submitter
- ATOH8 p.His197Pro Uncertain significance Single submitter
- ATOH8 p.Leu23Phe Uncertain significance Single submitter
- ATOH8 p.Leu7Pro Uncertain significance Single submitter
- ATOH8 p.Pro122Ser Uncertain significance Single submitter
- ATOH8 p.Pro137Leu Uncertain significance Single submitter
- ATOH8 p.Pro148Ser Uncertain significance Single submitter
- ATOH8 p.Pro152Ser Uncertain significance Single submitter
- ATOH8 p.Pro159Arg Uncertain significance Single submitter
- ATOH8 p.Pro181Ser Uncertain significance Single submitter
- ATOH8 p.Pro184Thr Uncertain significance Single submitter
- ATOH8 p.Pro214Ala Uncertain significance Single submitter
- ATOH8 p.Pro33Leu Uncertain significance Single submitter
- ATOH8 p.Pro52Ser Uncertain significance Single submitter
- ATOH8 p.Pro85Ser Uncertain significance Single submitter
- ATOH8 p.Ser177Thr Uncertain significance Single submitter
- ATOH8 p.Ser267Cys Uncertain significance Single submitter
- ATOH8 p.Ser267Thr Uncertain significance Single submitter
- ATOH8 p.Ser99Phe Uncertain significance Single submitter
- ATOH8 p.Thr178Pro Uncertain significance Single submitter
- ATOH8 p.Thr241Lys Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- ATOH8 p.Arg308His Uncertain significance Single submitter
- ATOH8 p.Ile199Ser Uncertain significance Single submitter
- ATOH8 p.Ile224Thr Uncertain significance Single submitter
- ATOH8 p.Ile274Val Uncertain significance Single submitter
- ATOH8 p.Lys225Glu Uncertain significance Single submitter
- ATOH8 p.Pro125Ser Uncertain significance Single submitter
- ATOH8 p.Pro128Leu Uncertain significance Single submitter
- ATOH8 p.Pro73Thr Uncertain significance Single submitter
All ATOH8 variants
Likely benign 2
- p.Gly94Arg Single submitter
- p.Ser134Gly Single submitter
Uncertain significance 58
- p.Pro169Arg Multiple submitters ⚠
- p.Tyr40Cys Multiple submitters congenital portosystemic shunt ⚠
- p.Ala101Thr Single submitter ⚠
- p.Ala107Val Single submitter congenital portosystemic shunt ⚠
- p.Ala113Val Single submitter ⚠
- p.Ala131Val Single submitter ⚠
- p.Ala142Gly Single submitter ⚠
- p.Ala170Thr Single submitter ⚠
- p.Ala312Thr Single submitter
- p.Ala49Gly Single submitter ⚠
- p.Ala81Gly Single submitter ⚠
- p.Ala81Thr Single submitter ⚠
- p.Ala93Val Single submitter ⚠
- p.Arg153Leu Single submitter
- p.Arg213Gly Single submitter
- p.Arg308His Single submitter ⚠
- p.Arg308Leu Single submitter ⚠
- p.Arg319His Single submitter ⚠
- p.Arg319Leu Single submitter ⚠
- p.Arg35Gly Single submitter ⚠
- p.Arg63Ser Single submitter ⚠
- p.Arg96Cys Single submitter ⚠
- p.Cys111Arg Single submitter ⚠
- p.Glu103Gln Single submitter ⚠
- p.Glu141Ala Single submitter ⚠
- p.Glu251Gln Single submitter ⚠
- p.Gly120Glu Single submitter ⚠
- p.Gly88Arg Single submitter ⚠
- p.Gly88Val Single submitter ⚠
- p.Gly89Arg Single submitter ⚠
- p.Gly89Cys Single submitter ⚠
- p.His197Pro Single submitter ⚠
- p.Ile199Ser Single submitter ⚠
- p.Ile224Thr Single submitter ⚠
- p.Ile274Val Single submitter ⚠
- p.Leu23Phe Single submitter ⚠
- p.Leu7Pro Single submitter ⚠
- p.Lys225Glu Single submitter ⚠
- p.Pro122Ser Single submitter ⚠
- p.Pro125Ser Single submitter ⚠
- p.Pro128Leu Single submitter ⚠
- p.Pro137Leu Single submitter ⚠
- p.Pro148Ser Single submitter ⚠
- p.Pro152Ser Single submitter ⚠
- p.Pro159Arg Single submitter ⚠
- p.Pro181Ser Single submitter ⚠
- p.Pro184Thr Single submitter ⚠
- p.Pro214Ala Single submitter ⚠
- p.Pro33Leu Single submitter ⚠
- p.Pro52Ser Single submitter ⚠
- p.Pro73Thr Single submitter ⚠
- p.Pro85Ser Single submitter ⚠
- p.Ser177Thr Single submitter ⚠
- p.Ser267Cys Single submitter ⚠
- p.Ser267Thr Single submitter ⚠
- p.Ser99Phe Single submitter ⚠
- p.Thr178Pro Single submitter ⚠
- p.Thr241Lys Single submitter ⚠