ATOSA — 145 ClinVar variants
All ClinVar germline ATOSA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 138 flagged for review →
7 Likely benign · 138 Uncertain significance
Full ATOSA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 138
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 100
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ATOSA p.Ala116Val Uncertain significance Single submitter
- ATOSA p.Ala121Val Uncertain significance Single submitter
- ATOSA p.Ala294Gly Uncertain significance Single submitter
- ATOSA p.Ala375Pro Uncertain significance Single submitter
- ATOSA p.Arg1012Gln Uncertain significance Single submitter
- ATOSA p.Arg266Cys Uncertain significance Single submitter
- ATOSA p.Arg266His Uncertain significance Single submitter
- ATOSA p.Arg349Cys Uncertain significance Single submitter
- ATOSA p.Arg349Ser Uncertain significance Single submitter
- ATOSA p.Arg370Trp Uncertain significance Single submitter
- ATOSA p.Arg446Gln Uncertain significance Single submitter
- ATOSA p.Arg453Gln Uncertain significance Single submitter
- ATOSA p.Arg505Gly Uncertain significance Single submitter
- ATOSA p.Arg73Gln Uncertain significance Single submitter
- ATOSA p.Arg979Gln Uncertain significance Single submitter
- ATOSA p.Asn136Lys Uncertain significance Single submitter
- ATOSA p.Asn173Ser Uncertain significance Single submitter
- ATOSA p.Asn202Thr Uncertain significance Single submitter
- ATOSA p.Asn681Lys Uncertain significance Single submitter
- ATOSA p.Asn728Ser Uncertain significance Single submitter
- ATOSA p.Asp102Asn Uncertain significance Single submitter
- ATOSA p.Asp103Asn Uncertain significance Single submitter
- ATOSA p.Asp184Val Uncertain significance Single submitter
- ATOSA p.Asp512Gly Uncertain significance Single submitter
- ATOSA p.Cys52Ser Uncertain significance Single submitter
- ATOSA p.Cys564Tyr Uncertain significance Single submitter
- ATOSA p.Cys576Tyr Uncertain significance Single submitter
- ATOSA p.Cys769Trp Uncertain significance Single submitter
- ATOSA p.Gln219Leu Uncertain significance Single submitter
- ATOSA p.Gln350His Uncertain significance Single submitter
- ATOSA p.Gln354Lys Uncertain significance Single submitter
- ATOSA p.Gln741Arg Uncertain significance Single submitter
- ATOSA p.Gln749Pro Uncertain significance Single submitter
- ATOSA p.Glu1009Gln Uncertain significance Single submitter
- ATOSA p.Glu130Asp Uncertain significance Single submitter
- ATOSA p.Glu330Lys Uncertain significance Single submitter
- ATOSA p.Glu600Lys Uncertain significance Single submitter
- ATOSA p.Gly234Ser Uncertain significance Single submitter
- ATOSA p.Gly305Asp Uncertain significance Single submitter
- ATOSA p.Gly937Asp Uncertain significance Single submitter
- ATOSA p.His205Tyr Uncertain significance Single submitter
- ATOSA p.His310Leu Uncertain significance Single submitter
- ATOSA p.His465Tyr Uncertain significance Single submitter
- ATOSA p.His511Gln Uncertain significance Single submitter
- ATOSA p.His544Tyr Uncertain significance Single submitter
- ATOSA p.Ile141Thr Uncertain significance Single submitter
- ATOSA p.Ile174Thr Uncertain significance Single submitter
- ATOSA p.Ile194Ser Uncertain significance Single submitter
- ATOSA p.Ile194Val Uncertain significance Single submitter
- ATOSA p.Ile323Val Uncertain significance Single submitter
- ATOSA p.Ile458Val Uncertain significance Single submitter
- ATOSA p.Ile542Val Uncertain significance Single submitter
- ATOSA p.Ile647Val Uncertain significance Single submitter
- ATOSA p.Ile723Leu Uncertain significance Single submitter
- ATOSA p.Ile873Val Uncertain significance Single submitter
- ATOSA p.Ile975Val Uncertain significance Single submitter
- ATOSA p.Leu245Phe Uncertain significance Single submitter
- ATOSA p.Leu336Ser Uncertain significance Single submitter
- ATOSA p.Leu408Val Uncertain significance Single submitter
- ATOSA p.Leu530Ser Uncertain significance Single submitter
- ATOSA p.Leu65Val Uncertain significance Single submitter
- ATOSA p.Leu720Ile Uncertain significance Single submitter
- ATOSA p.Leu800Ser Uncertain significance Single submitter
- ATOSA p.Lys299Glu Uncertain significance Single submitter
- ATOSA p.Lys604Arg Uncertain significance Single submitter
- ATOSA p.Lys629Asn Uncertain significance Single submitter
- ATOSA p.Lys649Asn Uncertain significance Single submitter
- ATOSA p.Lys655Asn Uncertain significance Single submitter
- ATOSA p.Lys686Gln Uncertain significance Single submitter
- ATOSA p.Lys735Gln Uncertain significance Single submitter
- ATOSA p.Met275Val Uncertain significance Single submitter
- ATOSA p.Met633Val Uncertain significance Single submitter
- ATOSA p.Met702Val Uncertain significance Single submitter
- ATOSA p.Met981Ile Uncertain significance Single submitter
- ATOSA p.Phe409Leu Uncertain significance Single submitter
- ATOSA p.Phe508Leu Uncertain significance Single submitter
- ATOSA p.Pro289Thr Uncertain significance Single submitter
- ATOSA p.Pro395Thr Uncertain significance Single submitter
- ATOSA p.Pro467Ala Uncertain significance Single submitter
- ATOSA p.Pro504Ser Uncertain significance Single submitter
- ATOSA p.Pro810Leu Uncertain significance Single submitter
- ATOSA p.Pro953Ser Uncertain significance Single submitter
- ATOSA p.Ser263Thr Uncertain significance Single submitter
- ATOSA p.Ser572Ile Uncertain significance Single submitter
- ATOSA p.Ser757Pro Uncertain significance Single submitter
- ATOSA p.Ser765Gly Uncertain significance Single submitter
- ATOSA p.Thr231Ser Uncertain significance Single submitter
- ATOSA p.Thr304Ser Uncertain significance Single submitter
- ATOSA p.Thr601Pro Uncertain significance Single submitter
- ATOSA p.Thr625Ile Uncertain significance Single submitter
- ATOSA p.Thr625Ser Uncertain significance Single submitter
- ATOSA p.Thr779Ile Uncertain significance Single submitter
- ATOSA p.Thr803Ser Uncertain significance Single submitter
- ATOSA p.Thr913Ala Uncertain significance Single submitter
- ATOSA p.Tyr301His Uncertain significance Single submitter
- ATOSA p.Tyr53Phe Uncertain significance Single submitter
- ATOSA p.Tyr699Cys Uncertain significance Single submitter
- ATOSA p.Val1002Leu Uncertain significance Single submitter
- ATOSA p.Val418Met Uncertain significance Single submitter
- ATOSA p.Val520Met Uncertain significance Single submitter
Predictors split 38
The independent predictors disagree with each other — read with care.
- ATOSA p.Arg134Gln Uncertain significance Single submitter
- ATOSA p.Arg370Gln Uncertain significance Single submitter
- ATOSA p.Arg505Gln Uncertain significance Single submitter
- ATOSA p.Arg505Trp Uncertain significance Single submitter
- ATOSA p.Arg69Cys Uncertain significance Single submitter
- ATOSA p.Arg72Gly Uncertain significance Single submitter
- ATOSA p.Asn360Asp Uncertain significance Single submitter
- ATOSA p.Asn397Ser Uncertain significance Single submitter
- ATOSA p.Asn620His Uncertain significance Single submitter
- ATOSA p.Asn965Ser Uncertain significance Single submitter
- ATOSA p.Asn984Ser Uncertain significance Single submitter
- ATOSA p.Asp484Asn Uncertain significance Single submitter
- ATOSA p.Asp512Tyr Uncertain significance Single submitter
- ATOSA p.Asp892Gly Uncertain significance Single submitter
- ATOSA p.Gln214His Uncertain significance Single submitter
- ATOSA p.Gln491Glu Uncertain significance Single submitter
- ATOSA p.Glu414Ala Uncertain significance Single submitter
- ATOSA p.Gly813Arg Uncertain significance Single submitter
- ATOSA p.His383Asp Uncertain significance Single submitter
- ATOSA p.Ile128Met Uncertain significance Single submitter
- ATOSA p.Ile363Thr Uncertain significance Single submitter
- ATOSA p.Ile503Phe Uncertain significance Single submitter
- ATOSA p.Leu1025Met Uncertain significance Single submitter
- ATOSA p.Lys519Glu Uncertain significance Single submitter
- ATOSA p.Phe12Val Uncertain significance Single submitter
- ATOSA p.Phe910Ser Uncertain significance Single submitter
- ATOSA p.Pro498Thr Uncertain significance Single submitter
- ATOSA p.Ser179Asn Uncertain significance Single submitter
- ATOSA p.Ser321Gly Uncertain significance Single submitter
- ATOSA p.Ser347Cys Uncertain significance Single submitter
- ATOSA p.Ser401Tyr Uncertain significance Single submitter
- ATOSA p.Ser412Ala Uncertain significance Single submitter
- ATOSA p.Ser869Arg Uncertain significance Single submitter
- ATOSA p.Ser869Gly Uncertain significance Single submitter
- ATOSA p.Ser943Phe Uncertain significance Single submitter
- ATOSA p.Thr226Met Uncertain significance Single submitter
- ATOSA p.Val1052Phe Uncertain significance Single submitter
- ATOSA p.Val921Ala Uncertain significance Single submitter
All ATOSA variants
Likely benign 7
- p.Arg764Lys Single submitter
- p.Arg793Gln Single submitter
- p.Glu537Asp Single submitter
- p.Gly636Glu Single submitter
- p.His251Arg Single submitter
- p.His580Arg Single submitter
- p.Phe434Leu Single submitter
Uncertain significance 138
- p.Ala116Val Single submitter ⚠
- p.Ala121Val Single submitter ⚠
- p.Ala294Gly Single submitter ⚠
- p.Ala375Pro Single submitter ⚠
- p.Arg1012Gln Single submitter ⚠
- p.Arg134Gln Single submitter ⚠
- p.Arg266Cys Single submitter ⚠
- p.Arg266His Single submitter ⚠
- p.Arg349Cys Single submitter ⚠
- p.Arg349Ser Single submitter ⚠
- p.Arg370Gln Single submitter ⚠
- p.Arg370Trp Single submitter ⚠
- p.Arg446Gln Single submitter ⚠
- p.Arg453Gln Single submitter ⚠
- p.Arg505Gln Single submitter ⚠
- p.Arg505Gly Single submitter ⚠
- p.Arg505Trp Single submitter ⚠
- p.Arg69Cys Single submitter ⚠
- p.Arg72Gly Single submitter ⚠
- p.Arg73Gln Single submitter ⚠
- p.Arg979Gln Single submitter ⚠
- p.Asn136Lys Single submitter ⚠
- p.Asn173Ser Single submitter ⚠
- p.Asn202Thr Single submitter ⚠
- p.Asn360Asp Single submitter ⚠
- p.Asn397Ser Single submitter ⚠
- p.Asn620His Single submitter ⚠
- p.Asn681Lys Single submitter ⚠
- p.Asn728Ser Single submitter ⚠
- p.Asn965Ser Single submitter ⚠
- p.Asn984Ser Single submitter ⚠
- p.Asp102Asn Single submitter ⚠
- p.Asp103Asn Single submitter ⚠
- p.Asp184Val Single submitter ⚠
- p.Asp484Asn Single submitter ⚠
- p.Asp512Gly Single submitter ⚠
- p.Asp512Tyr Single submitter ⚠
- p.Asp892Gly Single submitter ⚠
- p.Cys52Ser Single submitter ⚠
- p.Cys564Tyr Single submitter ⚠
- p.Cys576Tyr Single submitter ⚠
- p.Cys769Trp Single submitter ⚠
- p.Gln214His Single submitter ⚠
- p.Gln219Leu Single submitter ⚠
- p.Gln350His Single submitter ⚠
- p.Gln354Lys Single submitter ⚠
- p.Gln491Glu Single submitter ⚠
- p.Gln741Arg Single submitter ⚠
- p.Gln749Pro Single submitter ⚠
- p.Glu1009Gln Single submitter ⚠
- p.Glu130Asp Single submitter ⚠
- p.Glu330Lys Single submitter ⚠
- p.Glu414Ala Single submitter ⚠
- p.Glu600Lys Single submitter ⚠
- p.Gly234Ser Single submitter ⚠
- p.Gly305Asp Single submitter ⚠
- p.Gly813Arg Single submitter ⚠
- p.Gly937Asp Single submitter ⚠
- p.His205Tyr Single submitter ⚠
- p.His310Leu Single submitter ⚠
- p.His383Asp Single submitter ⚠
- p.His465Tyr Single submitter ⚠
- p.His511Gln Single submitter ⚠
- p.His544Tyr Single submitter ⚠
- p.Ile128Met Single submitter ⚠
- p.Ile141Thr Single submitter ⚠
- p.Ile174Thr Single submitter ⚠
- p.Ile194Ser Single submitter ⚠
- p.Ile194Val Single submitter ⚠
- p.Ile323Val Single submitter ⚠
- p.Ile363Thr Single submitter ⚠
- p.Ile458Val Single submitter ⚠
- p.Ile503Phe Single submitter ⚠
- p.Ile542Val Single submitter ⚠
- p.Ile647Val Single submitter ⚠
- p.Ile723Leu Single submitter ⚠
- p.Ile873Val Single submitter ⚠
- p.Ile975Val Single submitter ⚠
- p.Leu1025Met Single submitter ⚠
- p.Leu245Phe Single submitter ⚠
- p.Leu336Ser Single submitter ⚠
- p.Leu408Val Single submitter ⚠
- p.Leu530Ser Single submitter ⚠
- p.Leu65Val Single submitter ⚠
- p.Leu720Ile Single submitter ⚠
- p.Leu800Ser Single submitter ⚠
- p.Lys299Glu Single submitter ⚠
- p.Lys519Glu Single submitter ⚠
- p.Lys604Arg Single submitter ⚠
- p.Lys629Asn Single submitter ⚠
- p.Lys649Asn Single submitter ⚠
- p.Lys655Asn Single submitter ⚠
- p.Lys686Gln Single submitter ⚠
- p.Lys735Gln Single submitter ⚠
- p.Met275Val Single submitter ⚠
- p.Met633Val Single submitter ⚠
- p.Met702Val Single submitter ⚠
- p.Met981Ile Single submitter ⚠
- p.Phe12Val Single submitter ⚠
- p.Phe409Leu Single submitter ⚠
- p.Phe508Leu Single submitter ⚠
- p.Phe910Ser Single submitter ⚠
- p.Pro289Thr Single submitter ⚠
- p.Pro395Thr Single submitter ⚠
- p.Pro467Ala Single submitter ⚠
- p.Pro498Thr Single submitter ⚠
- p.Pro504Ser Single submitter ⚠
- p.Pro810Leu Single submitter ⚠
- p.Pro953Ser Single submitter ⚠
- p.Ser179Asn Single submitter ⚠
- p.Ser263Thr Single submitter ⚠
- p.Ser321Gly Single submitter ⚠
- p.Ser347Cys Single submitter ⚠
- p.Ser401Tyr Single submitter ⚠
- p.Ser412Ala Single submitter ⚠
- p.Ser572Ile Single submitter ⚠
- p.Ser757Pro Single submitter ⚠
- p.Ser765Gly Single submitter ⚠
- p.Ser869Arg Single submitter ⚠
- p.Ser869Gly Single submitter ⚠
- p.Ser943Phe Single submitter ⚠
- p.Thr226Met Single submitter ⚠
- p.Thr231Ser Single submitter ⚠
- p.Thr304Ser Single submitter ⚠
- p.Thr601Pro Single submitter ⚠
- p.Thr625Ile Single submitter ⚠
- p.Thr625Ser Single submitter ⚠
- p.Thr779Ile Single submitter ⚠
- p.Thr803Ser Single submitter ⚠
- p.Thr913Ala Single submitter ⚠
- p.Tyr301His Single submitter ⚠
- p.Tyr53Phe Single submitter ⚠
- p.Tyr699Cys Single submitter ⚠
- p.Val1002Leu Single submitter ⚠
- p.Val1052Phe Single submitter ⚠
- p.Val418Met Single submitter ⚠
- p.Val520Met Single submitter ⚠
- p.Val921Ala Single submitter ⚠