ATOX1 — 8 ClinVar variants
All ClinVar germline ATOX1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
8 Uncertain significance
Full ATOX1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 4
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 4
The independent predictors disagree with each other — read with care.
All ATOX1 variants
Uncertain significance 8
- p.Asp34Glu Single submitter ⚠
- p.Glu5Lys Single submitter ⚠
- p.Leu26Phe Single submitter ⚠
- p.Lys39Glu Single submitter ⚠
- p.Lys56Arg Single submitter ⚠
- p.Pro2Ser Single submitter ⚠
- p.Thr50Asn Single submitter ⚠
- p.Val19Leu Single submitter ⚠