ATP10D — 171 ClinVar variants
All ClinVar germline ATP10D variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 161 flagged for review →
1 Benign · 12 Likely benign · 158 Uncertain significance
Full ATP10D gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 161
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 99
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ATP10D p.Ala1236Thr Uncertain significance Single submitter
- ATP10D p.Ala35Thr Uncertain significance Single submitter
- ATP10D p.Ala35Val Uncertain significance Single submitter
- ATP10D p.Ala498Ser Uncertain significance Single submitter
- ATP10D p.Ala702Thr Uncertain significance Single submitter
- ATP10D p.Ala709Thr Uncertain significance Single submitter
- ATP10D p.Ala757Pro Uncertain significance Single submitter
- ATP10D p.Ala855Thr Uncertain significance Single submitter
- ATP10D p.Arg1044Pro Uncertain significance Single submitter
- ATP10D p.Arg1109Gln Uncertain significance Single submitter
- ATP10D p.Arg1373Lys Uncertain significance Single submitter
- ATP10D p.Arg225Gln Uncertain significance Single submitter
- ATP10D p.Arg256Gln Uncertain significance Single submitter
- ATP10D p.Arg502Lys Uncertain significance Single submitter
- ATP10D p.Arg606Gln Uncertain significance Single submitter
- ATP10D p.Arg745Trp Uncertain significance Single submitter
- ATP10D p.Arg747Trp Uncertain significance Single submitter
- ATP10D p.Arg859Lys Uncertain significance Single submitter
- ATP10D p.Arg989Gly Uncertain significance Single submitter
- ATP10D p.Asn110Ser Uncertain significance Single submitter
- ATP10D p.Asn411Asp Uncertain significance Single submitter
- ATP10D p.Asp438Asn Uncertain significance Single submitter
- ATP10D p.Asp459Glu Uncertain significance Single submitter
- ATP10D p.Asp557Ala Uncertain significance Single submitter
- ATP10D p.Asp990His Uncertain significance Single submitter
- ATP10D p.Cys1280Trp Uncertain significance Single submitter
- ATP10D p.Cys1391Tyr Uncertain significance Single submitter
- ATP10D p.Cys501Tyr Uncertain significance Single submitter
- ATP10D p.Gln1015Glu Uncertain significance Single submitter
- ATP10D p.Gln220His Uncertain significance Single submitter
- ATP10D p.Glu1077Ala Uncertain significance Single submitter
- ATP10D p.Glu1394Gln Uncertain significance Single submitter
- ATP10D p.Glu624Asp Uncertain significance Single submitter
- ATP10D p.Glu647Lys Uncertain significance Single submitter
- ATP10D p.Glu724Lys Uncertain significance Single submitter
- ATP10D p.Glu726Lys Uncertain significance Single submitter
- ATP10D p.Gly1078Val Uncertain significance Single submitter
- ATP10D p.Gly1220Asp Uncertain significance Single submitter
- ATP10D p.Gly1322Glu Uncertain significance Single submitter
- ATP10D p.Gly1322Val Uncertain significance Single submitter
- ATP10D p.Gly1354Ala Uncertain significance Single submitter
- ATP10D p.Gly26Glu Uncertain significance Single submitter
- ATP10D p.Gly615Arg Uncertain significance Single submitter
- ATP10D p.Gly616Glu Uncertain significance Single submitter
- ATP10D p.Gly703Ala Uncertain significance Single submitter
- ATP10D p.Gly707Ser Uncertain significance Single submitter
- ATP10D p.Gly893Cys Uncertain significance Single submitter
- ATP10D p.His1243Pro Uncertain significance Single submitter
- ATP10D p.His296Tyr Uncertain significance Single submitter
- ATP10D p.His699Arg Uncertain significance Single submitter
- ATP10D p.His910Asn Uncertain significance Single submitter
- ATP10D p.Ile1246Val Uncertain significance Single submitter
- ATP10D p.Ile545Thr Uncertain significance Single submitter
- ATP10D p.Ile593Val Uncertain significance Single submitter
- ATP10D p.Ile930Thr Uncertain significance Single submitter
- ATP10D p.Ile961Val Uncertain significance Single submitter
- ATP10D p.Leu435Val Uncertain significance Single submitter
- ATP10D p.Leu469Met Uncertain significance Single submitter
- ATP10D p.Leu662Phe Uncertain significance Single submitter
- ATP10D p.Leu83Arg Uncertain significance Single submitter
- ATP10D p.Lys137Thr Uncertain significance Single submitter
- ATP10D p.Lys349Arg Uncertain significance Single submitter
- ATP10D p.Lys413Glu Uncertain significance Single submitter
- ATP10D p.Met1079Ile Uncertain significance Single submitter
- ATP10D p.Met1294Val Uncertain significance Single submitter
- ATP10D p.Met193Ile Uncertain significance Single submitter
- ATP10D p.Met327Val Uncertain significance Single submitter
- ATP10D p.Met579Val Uncertain significance Single submitter
- ATP10D p.Met880Ile Uncertain significance Single submitter
- ATP10D p.Met956Val Uncertain significance Single submitter
- ATP10D p.Phe1133Leu Uncertain significance Single submitter
- ATP10D p.Phe436Leu Uncertain significance Single submitter
- ATP10D p.Phe95Leu Uncertain significance Single submitter
- ATP10D p.Pro27Arg Uncertain significance Single submitter
- ATP10D p.Pro27Gln Uncertain significance Single submitter
- ATP10D p.Pro496Leu Uncertain significance Single submitter
- ATP10D p.Pro683Leu Uncertain significance Single submitter
- ATP10D p.Pro713Ser Uncertain significance Single submitter
- ATP10D p.Pro811Gln Uncertain significance Single submitter
- ATP10D p.Ser1207Arg Uncertain significance Single submitter
- ATP10D p.Ser1248Thr Uncertain significance Single submitter
- ATP10D p.Ser241Gly Uncertain significance Single submitter
- ATP10D p.Ser491Asn Uncertain significance Single submitter
- ATP10D p.Ser500Gly Uncertain significance Single submitter
- ATP10D p.Ser560Gly Uncertain significance Single submitter
- ATP10D p.Thr1217Ala Uncertain significance Single submitter
- ATP10D p.Thr553Ile Uncertain significance Single submitter
- ATP10D p.Thr827Asn Uncertain significance Single submitter
- ATP10D p.Trp343Leu Uncertain significance Single submitter
- ATP10D p.Trp7Arg Uncertain significance Single submitter
- ATP10D p.Tyr1116Cys Uncertain significance Single submitter
- ATP10D p.Tyr1300Asn Uncertain significance Single submitter
- ATP10D p.Tyr1363Cys Uncertain significance Single submitter
- ATP10D p.Tyr160Cys Uncertain significance Single submitter
- ATP10D p.Tyr30Cys Uncertain significance Single submitter
- ATP10D p.Tyr389Ser Uncertain significance Single submitter
- ATP10D p.Val1147Ile Uncertain significance Single submitter
- ATP10D p.Val1382Ala Uncertain significance Single submitter
- ATP10D p.Val928Ile Uncertain significance Single submitter
Predictors split 62
The independent predictors disagree with each other — read with care.
- ATP10D p.Arg182His Benign Multiple submitters
- ATP10D p.Arg1030Gln Uncertain significance Single submitter
- ATP10D p.Arg1044Cys Uncertain significance Single submitter
- ATP10D p.Arg13Gln Likely benign Single submitter
- ATP10D p.Arg144Gln Uncertain significance Single submitter
- ATP10D p.Arg144Trp Uncertain significance Single submitter
- ATP10D p.Arg266His Uncertain significance Single submitter
- ATP10D p.Arg308Gln Uncertain significance Single submitter
- ATP10D p.Arg311His Uncertain significance Single submitter
- ATP10D p.Arg421Gln Uncertain significance Single submitter
- ATP10D p.Arg565Trp Uncertain significance Single submitter
- ATP10D p.Arg635Gln Uncertain significance Single submitter
- ATP10D p.Arg665Pro Uncertain significance Single submitter
- ATP10D p.Arg989Trp Uncertain significance Single submitter
- ATP10D p.Asn1233Ile Uncertain significance Single submitter
- ATP10D p.Asp1169Asn Uncertain significance Single submitter
- ATP10D p.Asp1222Tyr Uncertain significance Single submitter
- ATP10D p.Asp479Val Uncertain significance Single submitter
- ATP10D p.Asp481Asn Uncertain significance Single submitter
- ATP10D p.Asp557Gly Uncertain significance Single submitter
- ATP10D p.Asp851Ala Uncertain significance Single submitter
- ATP10D p.Cys279Ser Uncertain significance Single submitter
- ATP10D p.Cys680Tyr Uncertain significance Single submitter
- ATP10D p.Gln1015Arg Uncertain significance Single submitter
- ATP10D p.Gln419His Uncertain significance Single submitter
- ATP10D p.Glu187Lys Uncertain significance Single submitter
- ATP10D p.Glu412Gly Uncertain significance Single submitter
- ATP10D p.Gly615Trp Uncertain significance Single submitter
- ATP10D p.Gly616Trp Uncertain significance Single submitter
- ATP10D p.Gly760Glu Uncertain significance Single submitter
- ATP10D p.Gly996Val Uncertain significance Single submitter
- ATP10D p.Ile378Val Uncertain significance Single submitter
- ATP10D p.Ile403Val Uncertain significance Single submitter
- ATP10D p.Ile906Thr Uncertain significance Single submitter
- ATP10D p.Ile914Val Uncertain significance Single submitter
- ATP10D p.Leu1052Val Uncertain significance Single submitter
- ATP10D p.Leu1153Phe Uncertain significance Single submitter
- ATP10D p.Leu1200Ser Uncertain significance Single submitter
- ATP10D p.Leu1264Phe Uncertain significance Single submitter
- ATP10D p.Leu943Phe Uncertain significance Single submitter
- ATP10D p.Lys147Glu Uncertain significance Single submitter
- ATP10D p.Met1050Ile Uncertain significance Single submitter
- ATP10D p.Met803Val Uncertain significance Single submitter
- ATP10D p.Ser1037Gly Uncertain significance Single submitter
- ATP10D p.Ser1045Gly Uncertain significance Single submitter
- ATP10D p.Ser32Leu Uncertain significance Single submitter
- ATP10D p.Ser345Arg Uncertain significance Single submitter
- ATP10D p.Ser416Cys Uncertain significance Single submitter
- ATP10D p.Ser489Pro Uncertain significance Single submitter
- ATP10D p.Ser542Asn Uncertain significance Single submitter
- ATP10D p.Ser641Leu Uncertain significance Single submitter
- ATP10D p.Ser688Asn Likely benign Single submitter
- ATP10D p.Thr1306Met Uncertain significance Single submitter
- ATP10D p.Thr1307Met Uncertain significance Single submitter
- ATP10D p.Thr284Ser Uncertain significance Single submitter
- ATP10D p.Thr563Ile Uncertain significance Single submitter
- ATP10D p.Thr763Ala Uncertain significance Single submitter
- ATP10D p.Tyr1145His Uncertain significance Single submitter
- ATP10D p.Tyr1205Cys Uncertain significance Single submitter
- ATP10D p.Tyr401His Uncertain significance Single submitter
- ATP10D p.Val1302Ile Uncertain significance Single submitter
- ATP10D p.Val267Met Uncertain significance Single submitter
All ATP10D variants
Benign 1
- p.Arg182His Multiple submitters ⚠
Likely benign 12
- c.486-18dup Single submitter
- p.Arg13Gln Single submitter ⚠
- p.Gly1423Asp Single submitter
- p.Ile1260Thr Single submitter
- p.Ile1393Val Single submitter
- p.Ile156Val Single submitter
- p.Ser1399Pro Single submitter
- p.Ser253Asn Single submitter
- p.Ser688Asn Single submitter ⚠
- p.Thr1223Ile Single submitter
- p.Val1089Ile Single submitter
- p.Val355Ile Single submitter
Uncertain significance 158
- p.Ala1236Thr Single submitter ⚠
- p.Ala35Thr Single submitter ⚠
- p.Ala35Val Single submitter ⚠
- p.Ala498Ser Single submitter ⚠
- p.Ala702Thr Single submitter ⚠
- p.Ala709Thr Single submitter ⚠
- p.Ala757Pro Single submitter ⚠
- p.Ala855Thr Single submitter ⚠
- p.Arg1030Gln Single submitter ⚠
- p.Arg1044Cys Single submitter ⚠
- p.Arg1044Pro Single submitter ⚠
- p.Arg1109Gln Single submitter ⚠
- p.Arg1373Lys Single submitter ⚠
- p.Arg144Gln Single submitter ⚠
- p.Arg144Trp Single submitter ⚠
- p.Arg225Gln Single submitter ⚠
- p.Arg256Gln Single submitter ⚠
- p.Arg266His Single submitter ⚠
- p.Arg308Gln Single submitter ⚠
- p.Arg311His Single submitter ⚠
- p.Arg421Gln Single submitter ⚠
- p.Arg502Lys Single submitter ⚠
- p.Arg565Trp Single submitter ⚠
- p.Arg606Gln Single submitter ⚠
- p.Arg635Gln Single submitter ⚠
- p.Arg665Pro Single submitter ⚠
- p.Arg745Trp Single submitter ⚠
- p.Arg747Trp Single submitter ⚠
- p.Arg859Lys Single submitter ⚠
- p.Arg989Gly Single submitter ⚠
- p.Arg989Trp Single submitter ⚠
- p.Asn110Ser Single submitter ⚠
- p.Asn1233Ile Single submitter ⚠
- p.Asn411Asp Single submitter ⚠
- p.Asp1169Asn Single submitter ⚠
- p.Asp1222Tyr Single submitter ⚠
- p.Asp438Asn Single submitter ⚠
- p.Asp459Glu Single submitter ⚠
- p.Asp479Val Single submitter ⚠
- p.Asp481Asn Single submitter ⚠
- p.Asp557Ala Single submitter ⚠
- p.Asp557Gly Single submitter ⚠
- p.Asp851Ala Single submitter ⚠
- p.Asp990His Single submitter ⚠
- p.Cys1280Trp Single submitter ⚠
- p.Cys1391Tyr Single submitter ⚠
- p.Cys279Ser Single submitter ⚠
- p.Cys501Tyr Single submitter ⚠
- p.Cys680Tyr Single submitter ⚠
- p.Gln1015Arg Single submitter ⚠
- p.Gln1015Glu Single submitter ⚠
- p.Gln220His Single submitter ⚠
- p.Gln419His Single submitter ⚠
- p.Glu1077Ala Single submitter ⚠
- p.Glu1394Gln Single submitter ⚠
- p.Glu187Lys Single submitter ⚠
- p.Glu412Gly Single submitter ⚠
- p.Glu624Asp Single submitter ⚠
- p.Glu647Lys Single submitter ⚠
- p.Glu724Lys Single submitter ⚠
- p.Glu726Lys Single submitter ⚠
- p.Gly1078Val Single submitter ⚠
- p.Gly1220Asp Single submitter ⚠
- p.Gly1322Glu Single submitter ⚠
- p.Gly1322Val Single submitter ⚠
- p.Gly1354Ala Single submitter ⚠
- p.Gly26Glu Single submitter ⚠
- p.Gly615Arg Single submitter ⚠
- p.Gly615Trp Single submitter ⚠
- p.Gly616Glu Single submitter ⚠
- p.Gly616Trp Single submitter ⚠
- p.Gly703Ala Single submitter ⚠
- p.Gly707Ser Single submitter ⚠
- p.Gly760Glu Single submitter ⚠
- p.Gly893Cys Single submitter ⚠
- p.Gly996Val Single submitter ⚠
- p.His1243Pro Single submitter ⚠
- p.His296Tyr Single submitter ⚠
- p.His699Arg Single submitter ⚠
- p.His910Asn Single submitter ⚠
- p.Ile1246Val Single submitter ⚠
- p.Ile378Val Single submitter ⚠
- p.Ile403Val Single submitter ⚠
- p.Ile545Thr Single submitter ⚠
- p.Ile593Val Single submitter ⚠
- p.Ile906Thr Single submitter ⚠
- p.Ile914Val Single submitter ⚠
- p.Ile930Thr Single submitter ⚠
- p.Ile961Val Single submitter ⚠
- p.Leu1052Val Single submitter ⚠
- p.Leu1153Phe Single submitter ⚠
- p.Leu1200Ser Single submitter ⚠
- p.Leu1264Phe Single submitter ⚠
- p.Leu435Val Single submitter ⚠
- p.Leu469Met Single submitter ⚠
- p.Leu662Phe Single submitter ⚠
- p.Leu83Arg Single submitter ⚠
- p.Leu943Phe Single submitter ⚠
- p.Lys137Thr Single submitter ⚠
- p.Lys147Glu Single submitter ⚠
- p.Lys349Arg Single submitter ⚠
- p.Lys413Glu Single submitter ⚠
- p.Met1050Ile Single submitter ⚠
- p.Met1079Ile Single submitter ⚠
- p.Met1294Val Single submitter ⚠
- p.Met193Ile Single submitter ⚠
- p.Met327Val Single submitter ⚠
- p.Met579Val Single submitter ⚠
- p.Met803Val Single submitter ⚠
- p.Met880Ile Single submitter ⚠
- p.Met956Val Single submitter ⚠
- p.Phe1133Leu Single submitter ⚠
- p.Phe436Leu Single submitter ⚠
- p.Phe95Leu Single submitter ⚠
- p.Pro27Arg Single submitter ⚠
- p.Pro27Gln Single submitter ⚠
- p.Pro496Leu Single submitter ⚠
- p.Pro683Leu Single submitter ⚠
- p.Pro713Ser Single submitter ⚠
- p.Pro811Gln Single submitter ⚠
- p.Ser1037Gly Single submitter ⚠
- p.Ser1045Gly Single submitter ⚠
- p.Ser1207Arg Single submitter ⚠
- p.Ser1248Thr Single submitter ⚠
- p.Ser241Gly Single submitter ⚠
- p.Ser32Leu Single submitter ⚠
- p.Ser345Arg Single submitter ⚠
- p.Ser416Cys Single submitter ⚠
- p.Ser489Pro Single submitter ⚠
- p.Ser491Asn Single submitter ⚠
- p.Ser500Gly Single submitter ⚠
- p.Ser542Asn Single submitter ⚠
- p.Ser560Gly Single submitter ⚠
- p.Ser641Leu Single submitter ⚠
- p.Thr1217Ala Single submitter ⚠
- p.Thr1306Met Single submitter ⚠
- p.Thr1307Met Single submitter ⚠
- p.Thr284Ser Single submitter ⚠
- p.Thr553Ile Single submitter ⚠
- p.Thr563Ile Single submitter ⚠
- p.Thr763Ala Single submitter ⚠
- p.Thr827Asn Single submitter ⚠
- p.Trp343Leu Single submitter ⚠
- p.Trp7Arg Single submitter ⚠
- p.Tyr1116Cys Single submitter ⚠
- p.Tyr1145His Single submitter ⚠
- p.Tyr1205Cys Single submitter ⚠
- p.Tyr1300Asn Single submitter ⚠
- p.Tyr1363Cys Single submitter ⚠
- p.Tyr160Cys Single submitter ⚠
- p.Tyr30Cys Single submitter ⚠
- p.Tyr389Ser Single submitter ⚠
- p.Tyr401His Single submitter ⚠
- p.Val1147Ile Single submitter ⚠
- p.Val1302Ile Single submitter ⚠
- p.Val1382Ala Single submitter ⚠
- p.Val267Met Single submitter ⚠
- p.Val928Ile Single submitter ⚠