ATP11B — 120 ClinVar variants
All ClinVar germline ATP11B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 113 flagged for review →
2 Likely benign · 118 Uncertain significance
Full ATP11B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 113
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 96
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ATP11B p.Ala1072Val Uncertain significance Single submitter
- ATP11B p.Ala1129Val Uncertain significance Single submitter
- ATP11B p.Ala259Val Uncertain significance Single submitter
- ATP11B p.Ala518Thr Uncertain significance Single submitter
- ATP11B p.Ala653Gly Uncertain significance Single submitter
- ATP11B p.Ala749Ser Uncertain significance Single submitter
- ATP11B p.Ala749Val Uncertain significance Single submitter
- ATP11B p.Ala789Val Uncertain significance Single submitter
- ATP11B p.Arg1095Gln Uncertain significance Single submitter
- ATP11B p.Arg1139Gln Uncertain significance Single submitter
- ATP11B p.Arg165Gln Uncertain significance Single submitter
- ATP11B p.Arg223Gln Uncertain significance Single submitter
- ATP11B p.Arg578Lys Uncertain significance Single submitter
- ATP11B p.Arg646Cys Uncertain significance Single submitter
- ATP11B p.Arg651Lys Uncertain significance Single submitter
- ATP11B p.Arg689Gln Uncertain significance Single submitter
- ATP11B p.Arg6Gln Uncertain significance Single submitter
- ATP11B p.Arg6Leu Uncertain significance Single submitter
- ATP11B p.Arg794Cys Uncertain significance Single submitter
- ATP11B p.Arg794His Uncertain significance Single submitter
- ATP11B p.Asn200Ser Uncertain significance Single submitter
- ATP11B p.Asp1157Glu Uncertain significance Single submitter
- ATP11B p.Asp1163Asn Uncertain significance Single submitter
- ATP11B p.Asp510Asn Uncertain significance Single submitter
- ATP11B p.Asp644Gly Uncertain significance Single submitter
- ATP11B p.Asp986Glu Uncertain significance Single submitter
- ATP11B p.Asp986Gly Uncertain significance Single submitter
- ATP11B p.Gln1106Glu Uncertain significance Single submitter
- ATP11B p.Gln656His Uncertain significance Single submitter
- ATP11B p.Gln8His Uncertain significance Single submitter
- ATP11B p.Gln941Arg Uncertain significance Single submitter
- ATP11B p.Glu1125Gly Uncertain significance Single submitter
- ATP11B p.Glu562Gln Uncertain significance Single submitter
- ATP11B p.Glu641Gly Uncertain significance Single submitter
- ATP11B p.Glu641Lys Uncertain significance Single submitter
- ATP11B p.Glu740Lys Uncertain significance Single submitter
- ATP11B p.Gly10Ser Uncertain significance Single submitter
- ATP11B p.Gly1113Asp Uncertain significance Single submitter
- ATP11B p.Gly1134Glu Uncertain significance Single submitter
- ATP11B p.Gly32Val Uncertain significance Single submitter
- ATP11B p.His113Arg Uncertain significance Single submitter
- ATP11B p.His15Gln Uncertain significance Single submitter
- ATP11B p.His328Tyr Uncertain significance Single submitter
- ATP11B p.Ile1036Val Uncertain significance Single submitter
- ATP11B p.Ile103Val Uncertain significance Single submitter
- ATP11B p.Ile1049Phe Uncertain significance Single submitter
- ATP11B p.Ile208Val Uncertain significance Single submitter
- ATP11B p.Ile226Leu Uncertain significance Single submitter
- ATP11B p.Ile40Val Uncertain significance Single submitter
- ATP11B p.Ile543Val Uncertain significance Single submitter
- ATP11B p.Ile733Thr Uncertain significance Single submitter
- ATP11B p.Ile809Lys Uncertain significance Single submitter
- ATP11B p.Ile815Val Uncertain significance Single submitter
- ATP11B p.Ile918Val Uncertain significance Single submitter
- ATP11B p.Ile925Val Uncertain significance Single submitter
- ATP11B p.Ile950Val Uncertain significance Single submitter
- ATP11B p.Ile974Val Uncertain significance Single submitter
- ATP11B p.Leu33Phe Uncertain significance Single submitter
- ATP11B p.Leu436Val Uncertain significance Single submitter
- ATP11B p.Leu561Gln Uncertain significance Single submitter
- ATP11B p.Leu732Arg Uncertain significance Single submitter
- ATP11B p.Leu748Phe Uncertain significance Single submitter
- ATP11B p.Leu982Pro Uncertain significance Single submitter
- ATP11B p.Lys325Ile Uncertain significance Single submitter
- ATP11B p.Lys943Arg Uncertain significance Single submitter
- ATP11B p.Met553Ile Uncertain significance Single submitter
- ATP11B p.Met727Leu Uncertain significance Single submitter
- ATP11B p.Phe1123Cys Uncertain significance Single submitter
- ATP11B p.Phe648Tyr Uncertain significance Single submitter
- ATP11B p.Phe667Ser Uncertain significance Single submitter
- ATP11B p.Phe857Leu Uncertain significance Single submitter
- ATP11B p.Pro1124Gln Uncertain significance Single submitter
- ATP11B p.Pro1124Leu Uncertain significance Single submitter
- ATP11B p.Pro239Ser Uncertain significance Single submitter
- ATP11B p.Pro443Arg Uncertain significance Single submitter
- ATP11B p.Pro475Ser Uncertain significance Single submitter
- ATP11B p.Pro56Ser Uncertain significance Single submitter
- ATP11B p.Ser1150Thr Uncertain significance Single submitter
- ATP11B p.Ser1156Leu Uncertain significance Single submitter
- ATP11B p.Ser1175Cys Uncertain significance Single submitter
- ATP11B p.Ser332Thr Uncertain significance Single submitter
- ATP11B p.Ser455Thr Uncertain significance Single submitter
- ATP11B p.Ser970Ile Uncertain significance Single submitter
- ATP11B p.Thr101Ile Uncertain significance Single submitter
- ATP11B p.Thr1082Ile Uncertain significance Single submitter
- ATP11B p.Thr1171Lys Uncertain significance Single submitter
- ATP11B p.Thr192Ala Uncertain significance Single submitter
- ATP11B p.Thr960Ile Uncertain significance Single submitter
- ATP11B p.Tyr1160Cys Uncertain significance Single submitter
- ATP11B p.Tyr309Cys Uncertain significance Single submitter
- ATP11B p.Tyr632Cys Uncertain significance Single submitter
- ATP11B p.Val1062Met Uncertain significance Single submitter
- ATP11B p.Val172Ile Uncertain significance Single submitter
- ATP11B p.Val51Leu Uncertain significance Single submitter
- ATP11B p.Val664Ala Uncertain significance Single submitter
- ATP11B p.Val939Leu Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- ATP11B p.Ala247Val Uncertain significance Single submitter
- ATP11B p.Arg136Ile Uncertain significance Single submitter
- ATP11B p.Cys784Gly Uncertain significance Single submitter
- ATP11B p.Glu118Lys Uncertain significance Single submitter
- ATP11B p.Glu562Lys Uncertain significance Single submitter
- ATP11B p.His869Arg Uncertain significance Single submitter
- ATP11B p.Leu1066Phe Uncertain significance Single submitter
- ATP11B p.Leu732Phe Uncertain significance Single submitter
- ATP11B p.Leu863Met Uncertain significance Single submitter
- ATP11B p.Phe489Val Uncertain significance Single submitter
- ATP11B p.Phe665Val Uncertain significance Single submitter
- ATP11B p.Thr1100Ala Uncertain significance Single submitter
- ATP11B p.Thr326Ala Uncertain significance Single submitter
- ATP11B p.Tyr632His Uncertain significance Single submitter
- ATP11B p.Tyr928His Uncertain significance Single submitter
- ATP11B p.Val258Ala Uncertain significance Single submitter
- ATP11B p.Val764Leu Uncertain significance Single submitter
All ATP11B variants
Likely benign 2
- p.Ala1128Thr Single submitter
- p.Val24Ile Single submitter
Uncertain significance 118
- p.Ala1072Val Single submitter ⚠
- p.Ala1129Val Single submitter ⚠
- p.Ala247Val Single submitter ⚠
- p.Ala259Val Single submitter ⚠
- p.Ala518Thr Single submitter ⚠
- p.Ala653Gly Single submitter ⚠
- p.Ala749Ser Single submitter ⚠
- p.Ala749Val Single submitter ⚠
- p.Ala789Val Single submitter ⚠
- p.Arg1095Gln Single submitter ⚠
- p.Arg1139Gln Single submitter ⚠
- p.Arg136Ile Single submitter ⚠
- p.Arg165Gln Single submitter ⚠
- p.Arg223Gln Single submitter ⚠
- p.Arg578Lys Single submitter ⚠
- p.Arg646Cys Single submitter ⚠
- p.Arg651Lys Single submitter ⚠
- p.Arg689Gln Single submitter ⚠
- p.Arg6Gln Single submitter ⚠
- p.Arg6Leu Single submitter ⚠
- p.Arg794Cys Single submitter ⚠
- p.Arg794His Single submitter ⚠
- p.Asn200Ser Single submitter ⚠
- p.Asp1157Glu Single submitter ⚠
- p.Asp1163Asn Single submitter ⚠
- p.Asp510Asn Single submitter ⚠
- p.Asp644Gly Single submitter ⚠
- p.Asp986Glu Single submitter ⚠
- p.Asp986Gly Single submitter ⚠
- p.Asp986Tyr Single submitter
- p.Cys784Gly Single submitter ⚠
- p.Gln1106Glu Single submitter ⚠
- p.Gln656His Single submitter ⚠
- p.Gln8His Single submitter ⚠
- p.Gln941Arg Single submitter ⚠
- p.Glu1125Gly Single submitter ⚠
- p.Glu118Lys Single submitter ⚠
- p.Glu562Gln Single submitter ⚠
- p.Glu562Lys Single submitter ⚠
- p.Glu639Val Single submitter
- p.Glu641Gly Single submitter ⚠
- p.Glu641Lys Single submitter ⚠
- p.Glu740Lys Single submitter ⚠
- p.Gly10Ser Single submitter ⚠
- p.Gly1113Asp Single submitter ⚠
- p.Gly1134Glu Single submitter ⚠
- p.Gly32Val Single submitter ⚠
- p.Gly559Ala Single submitter
- p.His113Arg Single submitter ⚠
- p.His15Gln Single submitter ⚠
- p.His328Tyr Single submitter ⚠
- p.His869Arg Single submitter ⚠
- p.Ile1036Val Single submitter ⚠
- p.Ile103Val Single submitter ⚠
- p.Ile1049Phe Single submitter ⚠
- p.Ile208Val Single submitter ⚠
- p.Ile226Leu Single submitter ⚠
- p.Ile298Thr Single submitter
- p.Ile40Val Single submitter ⚠
- p.Ile543Val Single submitter ⚠
- p.Ile733Thr Single submitter ⚠
- p.Ile809Lys Single submitter ⚠
- p.Ile815Val Single submitter ⚠
- p.Ile918Val Single submitter ⚠
- p.Ile925Val Single submitter ⚠
- p.Ile950Val Single submitter ⚠
- p.Ile974Val Single submitter ⚠
- p.Leu1066Phe Single submitter ⚠
- p.Leu33Phe Single submitter ⚠
- p.Leu436Val Single submitter ⚠
- p.Leu561Gln Single submitter ⚠
- p.Leu732Arg Single submitter ⚠
- p.Leu732Phe Single submitter ⚠
- p.Leu748Phe Single submitter ⚠
- p.Leu863Met Single submitter ⚠
- p.Leu982Pro Single submitter ⚠
- p.Lys325Ile Single submitter ⚠
- p.Lys943Arg Single submitter ⚠
- p.Met553Ile Single submitter ⚠
- p.Met727Leu Single submitter ⚠
- p.Phe1123Cys Single submitter ⚠
- p.Phe489Val Single submitter ⚠
- p.Phe648Tyr Single submitter ⚠
- p.Phe665Val Single submitter ⚠
- p.Phe667Ser Single submitter ⚠
- p.Phe857Leu Single submitter ⚠
- p.Pro1124Gln Single submitter ⚠
- p.Pro1124Leu Single submitter ⚠
- p.Pro239Ser Single submitter ⚠
- p.Pro443Arg Single submitter ⚠
- p.Pro475Ser Single submitter ⚠
- p.Pro56Ser Single submitter ⚠
- p.Ser1150Thr Single submitter ⚠
- p.Ser1156Leu Single submitter ⚠
- p.Ser1175Cys Single submitter ⚠
- p.Ser332Thr Single submitter ⚠
- p.Ser455Thr Single submitter ⚠
- p.Ser970Ile Single submitter ⚠
- p.Thr101Ile Single submitter ⚠
- p.Thr1082Ile Single submitter ⚠
- p.Thr1100Ala Single submitter ⚠
- p.Thr1171Lys Single submitter ⚠
- p.Thr192Ala Single submitter ⚠
- p.Thr326Ala Single submitter ⚠
- p.Thr960Ile Single submitter ⚠
- p.Tyr1160Cys Single submitter ⚠
- p.Tyr309Cys Single submitter ⚠
- p.Tyr632Cys Single submitter ⚠
- p.Tyr632His Single submitter ⚠
- p.Tyr928His Single submitter ⚠
- p.Val1062Met Single submitter ⚠
- p.Val172Ile Single submitter ⚠
- p.Val258Ala Single submitter ⚠
- p.Val404Met Single submitter
- p.Val51Leu Single submitter ⚠
- p.Val664Ala Single submitter ⚠
- p.Val764Leu Single submitter ⚠
- p.Val939Leu Single submitter ⚠