ATP5IF1 — 14 ClinVar variants
All ClinVar germline ATP5IF1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 14 flagged for review →
14 Uncertain significance
Full ATP5IF1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 14
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ATP5IF1 p.Ala53Thr Uncertain significance Single submitter
- ATP5IF1 p.Arg50Gly Uncertain significance Single submitter
- ATP5IF1 p.Arg57Gln Uncertain significance Single submitter
- ATP5IF1 p.Asp105Tyr Uncertain significance Single submitter
- ATP5IF1 p.Asp28Gly Uncertain significance Single submitter
- ATP5IF1 p.Gly16Val Uncertain significance Single submitter
- ATP5IF1 p.Leu6Ser Uncertain significance Single submitter
- ATP5IF1 p.Leu6Trp Uncertain significance Single submitter
- ATP5IF1 p.Lys82Asn Uncertain significance Single submitter
- ATP5IF1 p.Lys82Gln Uncertain significance Single submitter
- ATP5IF1 p.Val3Met Uncertain significance Single submitter
- ATP5IF1 p.Val79Ile Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All ATP5IF1 variants
Uncertain significance 14
- p.Ala22Asp Single submitter ⚠
- p.Ala53Thr Single submitter ⚠
- p.Arg50Gly Single submitter ⚠
- p.Arg57Gln Single submitter ⚠
- p.Asp105Tyr Single submitter ⚠
- p.Asp28Gly Single submitter ⚠
- p.Gly16Val Single submitter ⚠
- p.Ile85Leu Single submitter ⚠
- p.Leu6Ser Single submitter ⚠
- p.Leu6Trp Single submitter ⚠
- p.Lys82Asn Single submitter ⚠
- p.Lys82Gln Single submitter ⚠
- p.Val3Met Single submitter ⚠
- p.Val79Ile Single submitter ⚠