ATP5ME — 18 ClinVar variants
All ClinVar germline ATP5ME variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 18 flagged for review →
18 Uncertain significance
Full ATP5ME gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 18
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ATP5ME p.Ala44Val Uncertain significance Single submitter
- ATP5ME p.Arg36Gln Uncertain significance Single submitter
- ATP5ME p.Asp65Asn Uncertain significance Single submitter
- ATP5ME p.Leu21Phe Uncertain significance Single submitter
- ATP5ME p.Leu54Pro Uncertain significance Single submitter
- ATP5ME p.Leu68Phe Uncertain significance Single submitter
- ATP5ME p.Lys50Gln Uncertain significance Single submitter
- ATP5ME p.Phe20Leu Uncertain significance Single submitter
- ATP5ME p.Pro35Ser Uncertain significance Single submitter
- ATP5ME p.Ser66Asn Uncertain significance Single submitter
- ATP5ME p.Ser8Cys Uncertain significance Single submitter
- ATP5ME p.Thr28Arg Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- ATP5ME p.Ala37Thr Uncertain significance Single submitter
- ATP5ME p.Arg29Cys Uncertain significance Single submitter
- ATP5ME p.Arg41Ser Uncertain significance Single submitter
- ATP5ME p.Glu38Gly Uncertain significance Single submitter
- ATP5ME p.Pro9Arg Uncertain significance Single submitter
- ATP5ME p.Ser66Arg Uncertain significance Single submitter
All ATP5ME variants
Uncertain significance 18
- p.Ala37Thr Single submitter ⚠
- p.Ala44Val Single submitter ⚠
- p.Arg29Cys Single submitter ⚠
- p.Arg36Gln Single submitter ⚠
- p.Arg41Ser Single submitter ⚠
- p.Asp65Asn Single submitter ⚠
- p.Glu38Gly Single submitter ⚠
- p.Leu21Phe Single submitter ⚠
- p.Leu54Pro Single submitter ⚠
- p.Leu68Phe Single submitter ⚠
- p.Lys50Gln Single submitter ⚠
- p.Phe20Leu Single submitter ⚠
- p.Pro35Ser Single submitter ⚠
- p.Pro9Arg Single submitter ⚠
- p.Ser66Arg Single submitter ⚠
- p.Ser66Asn Single submitter ⚠
- p.Ser8Cys Single submitter ⚠
- p.Thr28Arg Single submitter ⚠