ATP5PB — 45 ClinVar variants
All ClinVar germline ATP5PB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 45 flagged for review →
45 Uncertain significance
Full ATP5PB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 45
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ATP5PB p.Ala177Thr Uncertain significance Single submitter
- ATP5PB p.Ala250Thr Uncertain significance Single submitter
- ATP5PB p.Ala97Thr Uncertain significance Single submitter
- ATP5PB p.Gln144Glu Uncertain significance Single submitter
- ATP5PB p.Gln251Glu Uncertain significance Single submitter
- ATP5PB p.Glu213Lys Uncertain significance Single submitter
- ATP5PB p.Gly26Arg Uncertain significance Single submitter
- ATP5PB p.Gly51Arg Uncertain significance Single submitter
- ATP5PB p.Ile201Val Uncertain significance Single submitter
- ATP5PB p.Lys210Gln Uncertain significance Single submitter
- ATP5PB p.Lys90Glu Uncertain significance Single submitter
- ATP5PB p.Met109Val Uncertain significance Single submitter
- ATP5PB p.Met256Thr Uncertain significance Single submitter
- ATP5PB p.Pro15Ser Uncertain significance Single submitter
- ATP5PB p.Tyr199Cys Uncertain significance Single submitter
- ATP5PB p.Tyr50Cys Uncertain significance Single submitter
- ATP5PB p.Val223Met Uncertain significance Single submitter
- ATP5PB p.Val27Leu Uncertain significance Single submitter
- ATP5PB p.Val42Ile Uncertain significance Single submitter
- ATP5PB p.Val78Ile Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- ATP5PB p.Ala121Thr Uncertain significance Single submitter
- ATP5PB p.Ala241Val Uncertain significance Single submitter
- ATP5PB p.Ala247Val Uncertain significance Single submitter
- ATP5PB p.Arg183Gln Uncertain significance Single submitter
- ATP5PB p.Arg196Cys Uncertain significance Single submitter
- ATP5PB p.Arg196His Uncertain significance Single submitter
- ATP5PB p.Arg208Cys Uncertain significance Single submitter
- ATP5PB p.Arg208Gly Uncertain significance Single submitter
- ATP5PB p.Arg209Gln Uncertain significance Single submitter
- ATP5PB p.Gln212Glu Uncertain significance Single submitter
- ATP5PB p.Gln225His Uncertain significance Single submitter
- ATP5PB p.Glu184Gln Uncertain significance Single submitter
- ATP5PB p.Glu49Asp Uncertain significance Single submitter
- ATP5PB p.His200Arg Uncertain significance Single submitter
- ATP5PB p.Leu127Arg Uncertain significance Single submitter
- ATP5PB p.Lys53Arg Uncertain significance Single submitter
- ATP5PB p.Lys53Glu Uncertain significance Single submitter
- ATP5PB p.Pro15Leu Uncertain significance Single submitter
- ATP5PB p.Pro45Thr Uncertain significance Single submitter
- ATP5PB p.Ser16Phe Uncertain significance Single submitter
- ATP5PB p.Thr235Arg Uncertain significance Single submitter
- ATP5PB p.Tyr116Cys Uncertain significance Single submitter
- ATP5PB p.Val189Leu Uncertain significance Single submitter
- ATP5PB p.Val193Ile Uncertain significance Single submitter
- ATP5PB p.Val6Ile Uncertain significance Single submitter
All ATP5PB variants
Uncertain significance 45
- p.Ala121Thr Single submitter ⚠
- p.Ala177Thr Single submitter ⚠
- p.Ala241Val Single submitter ⚠
- p.Ala247Val Single submitter ⚠
- p.Ala250Thr Single submitter ⚠
- p.Ala97Thr Single submitter ⚠
- p.Arg183Gln Single submitter ⚠
- p.Arg196Cys Single submitter ⚠
- p.Arg196His Single submitter ⚠
- p.Arg208Cys Single submitter ⚠
- p.Arg208Gly Single submitter ⚠
- p.Arg209Gln Single submitter ⚠
- p.Gln144Glu Single submitter ⚠
- p.Gln212Glu Single submitter ⚠
- p.Gln225His Single submitter ⚠
- p.Gln251Glu Single submitter ⚠
- p.Glu184Gln Single submitter ⚠
- p.Glu213Lys Single submitter ⚠
- p.Glu49Asp Single submitter ⚠
- p.Gly26Arg Single submitter ⚠
- p.Gly51Arg Single submitter ⚠
- p.His200Arg Single submitter ⚠
- p.Ile201Val Single submitter ⚠
- p.Leu127Arg Single submitter ⚠
- p.Lys210Gln Single submitter ⚠
- p.Lys53Arg Single submitter ⚠
- p.Lys53Glu Single submitter ⚠
- p.Lys90Glu Single submitter ⚠
- p.Met109Val Single submitter ⚠
- p.Met256Thr Single submitter ⚠
- p.Pro15Leu Single submitter ⚠
- p.Pro15Ser Single submitter ⚠
- p.Pro45Thr Single submitter ⚠
- p.Ser16Phe Single submitter ⚠
- p.Thr235Arg Single submitter ⚠
- p.Tyr116Cys Single submitter ⚠
- p.Tyr199Cys Single submitter ⚠
- p.Tyr50Cys Single submitter ⚠
- p.Val189Leu Single submitter ⚠
- p.Val193Ile Single submitter ⚠
- p.Val223Met Single submitter ⚠
- p.Val27Leu Single submitter ⚠
- p.Val42Ile Single submitter ⚠
- p.Val6Ile Single submitter ⚠
- p.Val78Ile Single submitter ⚠