ATP6V1G1 — 17 ClinVar variants
All ClinVar germline ATP6V1G1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 17 flagged for review →
17 Uncertain significance
Full ATP6V1G1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 17
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ATP6V1G1 p.Arg26Leu Uncertain significance Single submitter
- ATP6V1G1 p.Arg48Cys Uncertain significance Single submitter
- ATP6V1G1 p.Ile116Leu Uncertain significance Single submitter
- ATP6V1G1 p.Leu12Arg Uncertain significance Single submitter
- ATP6V1G1 p.Phe102Leu Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- ATP6V1G1 p.Ala19Val Uncertain significance Single submitter
- ATP6V1G1 p.Ala61Val Uncertain significance Single submitter
- ATP6V1G1 p.Arg107Trp Uncertain significance Single submitter
- ATP6V1G1 p.Arg115Cys Uncertain significance Single submitter
- ATP6V1G1 p.Arg115His Uncertain significance Single submitter
- ATP6V1G1 p.Gln78Arg Uncertain significance Single submitter
- ATP6V1G1 p.Gln78Leu Uncertain significance Single submitter
- ATP6V1G1 p.Gln90His Uncertain significance Single submitter
- ATP6V1G1 p.Glu79Ala Uncertain significance Single submitter
- ATP6V1G1 p.Lys16Arg Uncertain significance Single submitter
- ATP6V1G1 p.Lys27Asn Uncertain significance Single submitter
- ATP6V1G1 p.Ser70Arg Uncertain significance Single submitter
All ATP6V1G1 variants
Uncertain significance 17
- p.Ala19Val Single submitter ⚠
- p.Ala61Val Single submitter ⚠
- p.Arg107Trp Single submitter ⚠
- p.Arg115Cys Single submitter ⚠
- p.Arg115His Single submitter ⚠
- p.Arg26Leu Single submitter ⚠
- p.Arg48Cys Single submitter ⚠
- p.Gln78Arg Single submitter ⚠
- p.Gln78Leu Single submitter ⚠
- p.Gln90His Single submitter ⚠
- p.Glu79Ala Single submitter ⚠
- p.Ile116Leu Single submitter ⚠
- p.Leu12Arg Single submitter ⚠
- p.Lys16Arg Single submitter ⚠
- p.Lys27Asn Single submitter ⚠
- p.Phe102Leu Single submitter ⚠
- p.Ser70Arg Single submitter ⚠