AURKA — 36 ClinVar variants
All ClinVar germline AURKA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
1 Likely pathogenic · 4 Benign · 5 Likely benign · 26 Uncertain significance
Full AURKA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors vs ClinVar 1
ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.
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AURKA p.Phe346Leu
Likely pathogenic
No assertion criteria
plasma cell myeloma
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AURKA p.Ala105Val Uncertain significance Single submitter
- AURKA p.Arg3Leu Uncertain significance Single submitter
- AURKA p.Asn367Asp Uncertain significance Single submitter
- AURKA p.Asn386His Uncertain significance Single submitter
- AURKA p.Asp294Tyr Uncertain significance Single submitter
- AURKA p.Cys49Gly Uncertain significance Single submitter
- AURKA p.Gln62Arg Uncertain significance Single submitter
- AURKA p.Gln72Arg Uncertain significance Single submitter
- AURKA p.Gln74His Uncertain significance Single submitter
- AURKA p.Glu112Asp Uncertain significance Single submitter
- AURKA p.Gly216Glu Uncertain significance Single submitter
- AURKA p.Ile237Met Uncertain significance Single submitter
- AURKA p.Leu323Ser Uncertain significance Single submitter
- AURKA p.Leu378Val Uncertain significance Single submitter
- AURKA p.Lys401Glu Uncertain significance Single submitter
- AURKA p.Lys5Glu Uncertain significance Single submitter
- AURKA p.Lys63Asn Uncertain significance Single submitter
- AURKA p.Pro87Leu Uncertain significance Single submitter
- AURKA p.Ser391Pro Uncertain significance Single submitter
- AURKA p.Thr347Ile Uncertain significance Single submitter
- AURKA p.Val206Ile Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All AURKA variants
Likely pathogenic 1
- p.Phe346Leu No assertion criteria plasma cell myeloma ⚠
Benign 4
- p.Asn7= Multiple submitters
- p.Phe31Ile Multiple submitters
- c.*3A>C No assertion criteria AURKA-related disorder
- p.Ile57Val No assertion criteria AURKA-related disorder
Likely benign 5
- p.Ala399Thr Single submitter
- p.Asn93Ser Single submitter
- p.Pro70Leu Single submitter
- c.320-6A>G No assertion criteria AURKA-related disorder
- p.Ser104Leu No assertion criteria AURKA-related disorder
Uncertain significance 26
- c.-5-7T>G Single submitter colorectal cancer
- p.Ala105Val Single submitter ⚠
- p.Arg251Thr Single submitter ⚠
- p.Arg362Ile Single submitter colorectal cancer ⚠
- p.Arg3Leu Single submitter ⚠
- p.Asn367Asp Single submitter ⚠
- p.Asn386His Single submitter ⚠
- p.Asp294Tyr Single submitter ⚠
- p.Cys49Gly Single submitter ⚠
- p.Gln62Arg Single submitter ⚠
- p.Gln72Arg Single submitter ⚠
- p.Gln74His Single submitter ⚠
- p.Glu112Asp Single submitter ⚠
- p.Gly216Glu Single submitter ⚠
- p.Ile237Met Single submitter ⚠
- p.Leu215Pro Single submitter ⚠
- p.Leu323Ser Single submitter ⚠
- p.Leu378Val Single submitter ⚠
- p.Lys401Glu Single submitter ⚠
- p.Lys5Glu Single submitter ⚠
- p.Lys63Asn Single submitter ⚠
- p.Pro87Leu Single submitter ⚠
- p.Ser391Pro Single submitter ⚠
- p.Thr347Ile Single submitter ⚠
- p.Tyr197Cys Single submitter
- p.Val206Ile Single submitter ⚠