AURKB — 34 ClinVar variants
All ClinVar germline AURKB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
1 Likely pathogenic · 1 Benign/Likely benign · 2 Likely benign · 30 Uncertain significance
Full AURKB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors vs ClinVar 1
ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.
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AURKB p.Arg283Cys
Likely pathogenic
No assertion criteria
NK-cell enteropathy
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AURKB p.Ala185Ser Uncertain significance Single submitter
- AURKB p.Arg44Cys Uncertain significance Single submitter
- AURKB p.Arg95Gly Uncertain significance Single submitter
- AURKB p.Asn279Lys Uncertain significance Single submitter
- AURKB p.Asn279Ser Uncertain significance Single submitter
- AURKB p.Asn46Asp Uncertain significance Single submitter
- AURKB p.Asp66Glu Uncertain significance Single submitter
- AURKB p.Gly63Glu Uncertain significance Single submitter
- AURKB p.Ile245Thr Uncertain significance Single submitter
- AURKB p.Leu105Pro Uncertain significance Single submitter
- AURKB p.Leu152Ser Uncertain significance Single submitter
- AURKB p.Lys194Arg Uncertain significance Single submitter
- AURKB p.Lys195Asn Uncertain significance Single submitter
- AURKB p.Lys98Arg Uncertain significance Single submitter
- AURKB p.Met42Ile Uncertain significance Single submitter
- AURKB p.Pro158Arg Uncertain significance Single submitter
- AURKB p.Pro25Leu Uncertain significance Single submitter
- AURKB p.Pro33Thr Uncertain significance Single submitter
- AURKB p.Val321Phe Uncertain significance Single submitter
- AURKB p.Val57Leu Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- AURKB p.Arg159Cys Uncertain significance Single submitter
- AURKB p.Arg248Cys Uncertain significance Single submitter
- AURKB p.Arg309Ser Uncertain significance Single submitter
- AURKB p.Gly160Arg Uncertain significance Single submitter
- AURKB p.Phe72Leu Uncertain significance Single submitter
- AURKB p.Pro325Arg Uncertain significance Single submitter
- AURKB p.Thr73Ile Uncertain significance Single submitter
- AURKB p.Val296Met Uncertain significance Single submitter
All AURKB variants
Likely pathogenic 1
- p.Arg283Cys No assertion criteria NK-cell enteropathy ⚠
Benign/Likely benign 1
- p.Gly212Arg Multiple submitters
Uncertain significance 30
- p.Ala185Ser Single submitter ⚠
- p.Arg159Cys Single submitter ⚠
- p.Arg176Leu Single submitter
- p.Arg248Cys Single submitter ⚠
- p.Arg309Ser Single submitter ⚠
- p.Arg44Cys Single submitter ⚠
- p.Arg95Gly Single submitter ⚠
- p.Asn279Lys Single submitter ⚠
- p.Asn279Ser Single submitter ⚠
- p.Asn46Asp Single submitter ⚠
- p.Asp66Glu Single submitter ⚠
- p.Glu165Ter Single submitter
- p.Gly160Arg Single submitter ⚠
- p.Gly63Glu Single submitter ⚠
- p.Ile245Thr Single submitter ⚠
- p.Leu105Pro Single submitter ⚠
- p.Leu152Ser Single submitter ⚠
- p.Lys194Arg Single submitter ⚠
- p.Lys195Asn Single submitter ⚠
- p.Lys98Arg Single submitter ⚠
- p.Met42Ile Single submitter ⚠
- p.Phe72Leu Single submitter ⚠
- p.Pro158Arg Single submitter ⚠
- p.Pro25Leu Single submitter ⚠
- p.Pro325Arg Single submitter ⚠
- p.Pro33Thr Single submitter ⚠
- p.Thr73Ile Single submitter ⚠
- p.Val296Met Single submitter ⚠
- p.Val321Phe Single submitter ⚠
- p.Val57Leu Single submitter ⚠