AVPR1B — 92 ClinVar variants
All ClinVar germline AVPR1B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 84 flagged for review →
9 Likely benign · 83 Uncertain significance
Full AVPR1B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 84
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AVPR1B p.Ala319Thr Uncertain significance Single submitter
- AVPR1B p.Arg141His Uncertain significance Single submitter
- AVPR1B p.Arg278Pro Uncertain significance Single submitter
- AVPR1B p.Arg29Gly Uncertain significance Single submitter
- AVPR1B p.Arg362Ser Uncertain significance Single submitter
- AVPR1B p.Arg375His Uncertain significance Single submitter
- AVPR1B p.Arg400Thr Uncertain significance Single submitter
- AVPR1B p.Arg408Ser Uncertain significance Single submitter
- AVPR1B p.Asp307Gly Uncertain significance Single submitter
- AVPR1B p.Asp312His Uncertain significance Single submitter
- AVPR1B p.Gln144Lys Uncertain significance Single submitter
- AVPR1B p.Gly240Val Uncertain significance Single submitter
- AVPR1B p.Gly327Asp Uncertain significance Single submitter
- AVPR1B p.Gly370Ser Uncertain significance Single submitter
- AVPR1B p.His138Arg Uncertain significance Single submitter
- AVPR1B p.Ile272Asn Uncertain significance Single submitter
- AVPR1B p.Ile277Thr Uncertain significance Single submitter
- AVPR1B p.Ile322Val Uncertain significance Single submitter
- AVPR1B p.Leu17Val Uncertain significance Single submitter
- AVPR1B p.Leu326Ser Uncertain significance Single submitter
- AVPR1B p.Leu379Arg Uncertain significance Single submitter
- AVPR1B p.Leu389Pro Uncertain significance Single submitter
- AVPR1B p.Met118Ile Uncertain significance Single submitter
- AVPR1B p.Met124Arg Uncertain significance Single submitter
- AVPR1B p.Met324Thr Uncertain significance Single submitter
- AVPR1B p.Phe424Ser Uncertain significance Single submitter
- AVPR1B p.Pro193Ser Uncertain significance Single submitter
- AVPR1B p.Pro335Ser Uncertain significance Single submitter
- AVPR1B p.Pro347Leu Uncertain significance Single submitter
- AVPR1B p.Pro386Leu Uncertain significance Single submitter
- AVPR1B p.Pro5Leu Uncertain significance Single submitter
- AVPR1B p.Ser373Leu Uncertain significance Single submitter
- AVPR1B p.Thr49Ile Uncertain significance Single submitter
- AVPR1B p.Trp158Cys Uncertain significance Single submitter
- AVPR1B p.Trp237Cys Uncertain significance Single submitter
- AVPR1B p.Val183Ala Uncertain significance Single submitter
- AVPR1B p.Val209Leu Uncertain significance Single submitter
Predictors split 47
The independent predictors disagree with each other — read with care.
- AVPR1B p.Leu113Val Uncertain significance Multiple submitters
- AVPR1B p.Ala34Thr Uncertain significance Single submitter
- AVPR1B p.Arg132Cys Uncertain significance Single submitter
- AVPR1B p.Arg175Trp Uncertain significance Single submitter
- AVPR1B p.Arg197Trp Uncertain significance Single submitter
- AVPR1B p.Arg238Pro Uncertain significance Single submitter
- AVPR1B p.Arg238Trp Uncertain significance Single submitter
- AVPR1B p.Arg260Trp Uncertain significance Single submitter
- AVPR1B p.Arg348Gln Uncertain significance Single submitter
- AVPR1B p.Arg348Trp Uncertain significance Single submitter
- AVPR1B p.Arg351His Uncertain significance Single submitter
- AVPR1B p.Arg365Gln Uncertain significance Single submitter
- AVPR1B p.Arg365Trp Uncertain significance Single submitter
- AVPR1B p.Arg366Gln Likely benign Single submitter
- AVPR1B p.Arg366Trp Uncertain significance Single submitter
- AVPR1B p.Arg375Cys Uncertain significance Single submitter
- AVPR1B p.Arg64Cys Uncertain significance Single submitter
- AVPR1B p.Arg66His Uncertain significance Single submitter
- AVPR1B p.Arg68Cys Uncertain significance Single submitter
- AVPR1B p.Arg99Cys Uncertain significance Single submitter
- AVPR1B p.Asn52Ser Uncertain significance Single submitter
- AVPR1B p.Asp104Asn Uncertain significance Single submitter
- AVPR1B p.Asp307Glu Uncertain significance Single submitter
- AVPR1B p.Cys223Phe Uncertain significance Single submitter
- AVPR1B p.Gly180Val Uncertain significance Single submitter
- AVPR1B p.Gly261Glu Uncertain significance Single submitter
- AVPR1B p.Ile269Asn Uncertain significance Single submitter
- AVPR1B p.Ile38Met Uncertain significance Single submitter
- AVPR1B p.Met324Ile Uncertain significance Single submitter
- AVPR1B p.Phe172Tyr Uncertain significance Single submitter
- AVPR1B p.Pro103Arg Uncertain significance Single submitter
- AVPR1B p.Ser268Asn Uncertain significance Single submitter
- AVPR1B p.Ser268Gly Uncertain significance Single submitter
- AVPR1B p.Ser373Trp Uncertain significance Single submitter
- AVPR1B p.Ser383Phe Uncertain significance Single submitter
- AVPR1B p.Ser390Asn Uncertain significance Single submitter
- AVPR1B p.Ser394Ile Uncertain significance Single submitter
- AVPR1B p.Thr216Arg Uncertain significance Single submitter
- AVPR1B p.Thr216Met Uncertain significance Single submitter
- AVPR1B p.Thr283Asn Uncertain significance Single submitter
- AVPR1B p.Thr378Met Uncertain significance Single submitter
- AVPR1B p.Thr58Ile Uncertain significance Single submitter
- AVPR1B p.Tyr133Cys Uncertain significance Single submitter
- AVPR1B p.Val110Leu Uncertain significance Single submitter
- AVPR1B p.Val115Ala Uncertain significance Single submitter
- AVPR1B p.Val318Glu Uncertain significance Single submitter
- AVPR1B p.Val73Ala Uncertain significance Single submitter
All AVPR1B variants
Likely benign 9
- p.Thr129= Multiple submitters
- p.Trp187Arg Multiple submitters
- p.Ala419Thr Single submitter
- p.Arg366Gln Single submitter ⚠
- p.Arg382His Single submitter
- p.Arg402Gly Single submitter
- p.Gly242Arg Single submitter
- p.Pro90= Single submitter
- p.Thr378= Single submitter
Uncertain significance 83
- p.Leu113Val Multiple submitters ⚠
- p.Ala319Thr Single submitter ⚠
- p.Ala34Thr Single submitter ⚠
- p.Arg132Cys Single submitter ⚠
- p.Arg141His Single submitter ⚠
- p.Arg175Trp Single submitter ⚠
- p.Arg197Trp Single submitter ⚠
- p.Arg238Pro Single submitter ⚠
- p.Arg238Trp Single submitter ⚠
- p.Arg260Trp Single submitter ⚠
- p.Arg278Pro Single submitter ⚠
- p.Arg29Gly Single submitter ⚠
- p.Arg348Gln Single submitter ⚠
- p.Arg348Trp Single submitter ⚠
- p.Arg351His Single submitter ⚠
- p.Arg362Ser Single submitter ⚠
- p.Arg365Gln Single submitter ⚠
- p.Arg365Trp Single submitter ⚠
- p.Arg366Trp Single submitter ⚠
- p.Arg375Cys Single submitter ⚠
- p.Arg375His Single submitter ⚠
- p.Arg400Thr Single submitter ⚠
- p.Arg408Ser Single submitter ⚠
- p.Arg64Cys Single submitter ⚠
- p.Arg66His Single submitter ⚠
- p.Arg68Cys Single submitter ⚠
- p.Arg99Cys Single submitter ⚠
- p.Asn52Ser Single submitter ⚠
- p.Asp104Asn Single submitter ⚠
- p.Asp307Glu Single submitter ⚠
- p.Asp307Gly Single submitter ⚠
- p.Asp312His Single submitter ⚠
- p.Cys223Phe Single submitter ⚠
- p.Gln144Lys Single submitter ⚠
- p.Gly180Val Single submitter ⚠
- p.Gly240Val Single submitter ⚠
- p.Gly261Glu Single submitter ⚠
- p.Gly327Asp Single submitter ⚠
- p.Gly370Ser Single submitter ⚠
- p.His138Arg Single submitter ⚠
- p.Ile269Asn Single submitter ⚠
- p.Ile272Asn Single submitter ⚠
- p.Ile277Thr Single submitter ⚠
- p.Ile322Val Single submitter ⚠
- p.Ile38Met Single submitter ⚠
- p.Leu17Val Single submitter ⚠
- p.Leu326Ser Single submitter ⚠
- p.Leu379Arg Single submitter ⚠
- p.Leu389Pro Single submitter ⚠
- p.Met118Ile Single submitter ⚠
- p.Met124Arg Single submitter ⚠
- p.Met324Ile Single submitter ⚠
- p.Met324Thr Single submitter ⚠
- p.Phe172Tyr Single submitter ⚠
- p.Phe424Ser Single submitter ⚠
- p.Pro103Arg Single submitter ⚠
- p.Pro193Ser Single submitter ⚠
- p.Pro335Ser Single submitter ⚠
- p.Pro347Leu Single submitter ⚠
- p.Pro386Leu Single submitter ⚠
- p.Pro5Leu Single submitter ⚠
- p.Ser268Asn Single submitter ⚠
- p.Ser268Gly Single submitter ⚠
- p.Ser373Leu Single submitter ⚠
- p.Ser373Trp Single submitter ⚠
- p.Ser383Phe Single submitter ⚠
- p.Ser390Asn Single submitter ⚠
- p.Ser394Ile Single submitter ⚠
- p.Thr216Arg Single submitter ⚠
- p.Thr216Met Single submitter ⚠
- p.Thr283Asn Single submitter ⚠
- p.Thr378Met Single submitter ⚠
- p.Thr49Ile Single submitter ⚠
- p.Thr58Ile Single submitter ⚠
- p.Trp158Cys Single submitter ⚠
- p.Trp237Cys Single submitter ⚠
- p.Tyr133Cys Single submitter ⚠
- p.Val110Leu Single submitter ⚠
- p.Val115Ala Single submitter ⚠
- p.Val183Ala Single submitter ⚠
- p.Val209Leu Single submitter ⚠
- p.Val318Glu Single submitter ⚠
- p.Val73Ala Single submitter ⚠