AZI2 — 43 ClinVar variants
All ClinVar germline AZI2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
43 Uncertain significance
Full AZI2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AZI2 p.Asn114Ser Uncertain significance Single submitter
- AZI2 p.Asn157Asp Uncertain significance Single submitter
- AZI2 p.Asn322Ser Uncertain significance Single submitter
- AZI2 p.Asn385His Uncertain significance Single submitter
- AZI2 p.Asp104Asn Uncertain significance Single submitter
- AZI2 p.Asp197Glu Uncertain significance Single submitter
- AZI2 p.Asp269Ala Uncertain significance Single submitter
- AZI2 p.Cys296Tyr Uncertain significance Single submitter
- AZI2 p.Gly171Ser Uncertain significance Single submitter
- AZI2 p.Gly267Val Uncertain significance Single submitter
- AZI2 p.Gly340Ser Uncertain significance Single submitter
- AZI2 p.His170Arg Uncertain significance Single submitter
- AZI2 p.His234Tyr Uncertain significance Single submitter
- AZI2 p.His384Arg Uncertain significance Single submitter
- AZI2 p.Ile28Val Uncertain significance Single submitter
- AZI2 p.Ile74Arg Uncertain significance Single submitter
- AZI2 p.Leu266Pro Uncertain significance Single submitter
- AZI2 p.Leu375Val Uncertain significance Single submitter
- AZI2 p.Leu381Trp Uncertain significance Single submitter
- AZI2 p.Lys181Thr Uncertain significance Single submitter
- AZI2 p.Lys254Glu Uncertain significance Single submitter
- AZI2 p.Lys391Glu Uncertain significance Single submitter
- AZI2 p.Met230Val Uncertain significance Single submitter
- AZI2 p.Phe77Ser Uncertain significance Single submitter
- AZI2 p.Pro377Ser Uncertain significance Single submitter
- AZI2 p.Ser118Phe Uncertain significance Single submitter
- AZI2 p.Ser120Phe Uncertain significance Single submitter
- AZI2 p.Ser325Ala Uncertain significance Single submitter
- AZI2 p.Ser82Asn Uncertain significance Single submitter
- AZI2 p.Thr196Met Uncertain significance Single submitter
- AZI2 p.Thr283Ala Uncertain significance Single submitter
- AZI2 p.Thr299Ile Uncertain significance Single submitter
- AZI2 p.Thr365Ser Uncertain significance Single submitter
- AZI2 p.Val142Ala Uncertain significance Single submitter
- AZI2 p.Val142Leu Uncertain significance Single submitter
- AZI2 p.Val142Met Uncertain significance Single submitter
- AZI2 p.Val260Ala Uncertain significance Single submitter
- AZI2 p.Val309Phe Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All AZI2 variants
Uncertain significance 43
- p.Ala36Pro Single submitter ⚠
- p.Arg67Ile Single submitter ⚠
- p.Asn114Ser Single submitter ⚠
- p.Asn157Asp Single submitter ⚠
- p.Asn322Ser Single submitter ⚠
- p.Asn385His Single submitter ⚠
- p.Asn59Ser Single submitter ⚠
- p.Asp104Asn Single submitter ⚠
- p.Asp197Glu Single submitter ⚠
- p.Asp269Ala Single submitter ⚠
- p.Cys296Tyr Single submitter ⚠
- p.Gly171Ser Single submitter ⚠
- p.Gly267Val Single submitter ⚠
- p.Gly340Ser Single submitter ⚠
- p.His170Arg Single submitter ⚠
- p.His234Tyr Single submitter ⚠
- p.His384Arg Single submitter ⚠
- p.Ile28Val Single submitter ⚠
- p.Ile48Asn Single submitter ⚠
- p.Ile74Arg Single submitter ⚠
- p.Leu266Pro Single submitter ⚠
- p.Leu375Val Single submitter ⚠
- p.Leu381Trp Single submitter ⚠
- p.Lys181Thr Single submitter ⚠
- p.Lys254Glu Single submitter ⚠
- p.Lys391Glu Single submitter ⚠
- p.Met230Val Single submitter ⚠
- p.Phe77Ser Single submitter ⚠
- p.Pro377Ser Single submitter ⚠
- p.Ser118Phe Single submitter ⚠
- p.Ser120Phe Single submitter ⚠
- p.Ser325Ala Single submitter ⚠
- p.Ser82Asn Single submitter ⚠
- p.Thr196Met Single submitter ⚠
- p.Thr283Ala Single submitter ⚠
- p.Thr299Ile Single submitter ⚠
- p.Thr365Ser Single submitter ⚠
- p.Trp319Arg Single submitter ⚠
- p.Val142Ala Single submitter ⚠
- p.Val142Leu Single submitter ⚠
- p.Val142Met Single submitter ⚠
- p.Val260Ala Single submitter ⚠
- p.Val309Phe Single submitter ⚠