B3GNT3 — 59 ClinVar variants
All ClinVar germline B3GNT3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
2 Benign · 9 Likely benign · 48 Uncertain significance
Full B3GNT3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- B3GNT3 p.Ala104Thr Uncertain significance Single submitter
- B3GNT3 p.Ala16Val Uncertain significance Single submitter
- B3GNT3 p.Ala281Thr Uncertain significance Single submitter
- B3GNT3 p.Ala59Asp Uncertain significance Single submitter
- B3GNT3 p.Ala63Thr Uncertain significance Single submitter
- B3GNT3 p.Arg122Pro Uncertain significance Single submitter
- B3GNT3 p.Arg127Leu Uncertain significance Single submitter
- B3GNT3 p.Arg128Gly Uncertain significance Single submitter
- B3GNT3 p.Arg142His Uncertain significance Single submitter
- B3GNT3 p.Arg161Trp Uncertain significance Single submitter
- B3GNT3 p.Arg263Gln Uncertain significance Single submitter
- B3GNT3 p.Arg284Cys Uncertain significance Single submitter
- B3GNT3 p.Arg284His Uncertain significance Single submitter
- B3GNT3 p.Arg323Trp Uncertain significance Single submitter
- B3GNT3 p.Arg5Trp Uncertain significance Single submitter
- B3GNT3 p.Asp97Glu Uncertain significance Single submitter
- B3GNT3 p.Gln368His Uncertain significance Single submitter
- B3GNT3 p.Gln76Arg Uncertain significance Single submitter
- B3GNT3 p.Glu155Lys Uncertain significance Single submitter
- B3GNT3 p.Glu262Lys Uncertain significance Single submitter
- B3GNT3 p.Gly18Ser Uncertain significance Single submitter
- B3GNT3 p.His227Arg Uncertain significance Single submitter
- B3GNT3 p.Leu329Met Uncertain significance Single submitter
- B3GNT3 p.Lys2Asn Uncertain significance Single submitter
- B3GNT3 p.Pro100Arg Uncertain significance Single submitter
- B3GNT3 p.Pro100Leu Uncertain significance Single submitter
- B3GNT3 p.Pro100Ser Uncertain significance Single submitter
- B3GNT3 p.Pro266His Uncertain significance Single submitter
- B3GNT3 p.Pro41Leu Uncertain significance Single submitter
- B3GNT3 p.Pro41Ser Uncertain significance Single submitter
- B3GNT3 p.Pro58Leu Uncertain significance Single submitter
- B3GNT3 p.Pro60Gln Uncertain significance Single submitter
- B3GNT3 p.Pro99Ser Uncertain significance Single submitter
- B3GNT3 p.Ser315Asn Uncertain significance Single submitter
- B3GNT3 p.Thr198Lys Uncertain significance Single submitter
- B3GNT3 p.Thr21Ser Uncertain significance Single submitter
- B3GNT3 p.Thr279Met Uncertain significance Single submitter
- B3GNT3 p.Thr369Ser Uncertain significance Single submitter
- B3GNT3 p.Val206Met Uncertain significance Single submitter
- B3GNT3 p.Val221Ile Uncertain significance Single submitter
- B3GNT3 p.Val242Met Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All B3GNT3 variants
Benign 2
- p.Pro44= Multiple submitters
- p.Thr319Met Multiple submitters ⚠
Likely benign 9
- p.Ala150Asp Single submitter
- p.Arg137Gln Single submitter
- p.Arg231His Single submitter
- p.Arg323Gln Single submitter
- p.Asn362= Single submitter
- p.Gln81Arg Single submitter
- p.Gly366Ser Single submitter
- p.Phe248Leu Single submitter
- p.Val206Leu Single submitter
Uncertain significance 48
- p.Ala104Thr Single submitter ⚠
- p.Ala16Val Single submitter ⚠
- p.Ala281Thr Single submitter ⚠
- p.Ala59Asp Single submitter ⚠
- p.Ala63Thr Single submitter ⚠
- p.Arg122Cys Single submitter
- p.Arg122Pro Single submitter ⚠
- p.Arg127Leu Single submitter ⚠
- p.Arg128Gly Single submitter ⚠
- p.Arg142His Single submitter ⚠
- p.Arg161Trp Single submitter ⚠
- p.Arg263Gln Single submitter ⚠
- p.Arg284Cys Single submitter ⚠
- p.Arg284His Single submitter ⚠
- p.Arg323Trp Single submitter ⚠
- p.Arg345Cys Single submitter
- p.Arg345His Single submitter ⚠
- p.Arg5Trp Single submitter ⚠
- p.Asp97Glu Single submitter ⚠
- p.Gln368His Single submitter ⚠
- p.Gln76Arg Single submitter ⚠
- p.Glu155Lys Single submitter ⚠
- p.Glu262Lys Single submitter ⚠
- p.Gly138Val Single submitter
- p.Gly18Ser Single submitter ⚠
- p.Gly316Ser Single submitter ⚠
- p.His216Gln Single submitter ⚠
- p.His227Arg Single submitter ⚠
- p.Leu329Met Single submitter ⚠
- p.Lys2Asn Single submitter ⚠
- p.Pro100Arg Single submitter ⚠
- p.Pro100Leu Single submitter ⚠
- p.Pro100Ser Single submitter ⚠
- p.Pro266His Single submitter ⚠
- p.Pro41Leu Single submitter ⚠
- p.Pro41Ser Single submitter ⚠
- p.Pro58Leu Single submitter ⚠
- p.Pro60Gln Single submitter ⚠
- p.Pro99His Single submitter ⚠
- p.Pro99Ser Single submitter ⚠
- p.Ser315Asn Single submitter ⚠
- p.Thr198Lys Single submitter ⚠
- p.Thr21Ser Single submitter ⚠
- p.Thr279Met Single submitter ⚠
- p.Thr369Ser Single submitter ⚠
- p.Val206Met Single submitter ⚠
- p.Val221Ile Single submitter ⚠
- p.Val242Met Single submitter ⚠