B4GALT4 — 40 ClinVar variants
All ClinVar germline B4GALT4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
3 Likely benign · 37 Uncertain significance
Full B4GALT4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- B4GALT4 p.Ala125Thr Uncertain significance Single submitter
- B4GALT4 p.Ala67Val Uncertain significance Single submitter
- B4GALT4 p.Arg110Lys Uncertain significance Single submitter
- B4GALT4 p.Arg227Cys Uncertain significance Single submitter
- B4GALT4 p.Arg310Gln Uncertain significance Single submitter
- B4GALT4 p.Asn132Lys Uncertain significance Single submitter
- B4GALT4 p.Asn201Ser Uncertain significance Single submitter
- B4GALT4 p.Asn32Tyr Uncertain significance Single submitter
- B4GALT4 p.Asp188Asn Uncertain significance Single submitter
- B4GALT4 p.Asp194His Uncertain significance Single submitter
- B4GALT4 p.Asp75Gly Uncertain significance Single submitter
- B4GALT4 p.Glu259Ala Uncertain significance Single submitter
- B4GALT4 p.Lys213Arg Uncertain significance Single submitter
- B4GALT4 p.Lys283Arg Uncertain significance Single submitter
- B4GALT4 p.Lys293Asn Uncertain significance Single submitter
- B4GALT4 p.Phe34Leu Uncertain significance Single submitter
- B4GALT4 p.Pro129Thr Uncertain significance Single submitter
- B4GALT4 p.Pro199Leu Uncertain significance Single submitter
- B4GALT4 p.Pro42Arg Uncertain significance Single submitter
- B4GALT4 p.Ser109Tyr Uncertain significance Single submitter
- B4GALT4 p.Ser229Arg Uncertain significance Single submitter
- B4GALT4 p.Ser318Asn Uncertain significance Single submitter
- B4GALT4 p.Thr290Ala Uncertain significance Single submitter
- B4GALT4 p.Thr69Met Uncertain significance Single submitter
- B4GALT4 p.Tyr33Ser Uncertain significance Single submitter
- B4GALT4 p.Val159Ala Uncertain significance Single submitter
- B4GALT4 p.Val217Ala Uncertain significance Single submitter
- B4GALT4 p.Val308Ala Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- B4GALT4 p.Ala237Ser Uncertain significance Single submitter
- B4GALT4 p.Ala237Val Uncertain significance Single submitter
- B4GALT4 p.Arg227Leu Uncertain significance Single submitter
- B4GALT4 p.Arg276Gln Uncertain significance Single submitter
- B4GALT4 p.Asp261Asn Uncertain significance Single submitter
- B4GALT4 p.Phe288Val Uncertain significance Single submitter
- B4GALT4 p.Pro78Arg Uncertain significance Single submitter
- B4GALT4 p.Thr285Ala Uncertain significance Single submitter
- B4GALT4 p.Val216Met Uncertain significance Single submitter
All B4GALT4 variants
Likely benign 3
- p.Arg114His Single submitter
- p.Ile91Val Single submitter
- p.Phe47Leu Single submitter
Uncertain significance 37
- p.Ala125Thr Single submitter ⚠
- p.Ala237Ser Single submitter ⚠
- p.Ala237Val Single submitter ⚠
- p.Ala67Val Single submitter ⚠
- p.Arg110Lys Single submitter ⚠
- p.Arg227Cys Single submitter ⚠
- p.Arg227Leu Single submitter ⚠
- p.Arg276Gln Single submitter ⚠
- p.Arg310Gln Single submitter ⚠
- p.Asn132Lys Single submitter ⚠
- p.Asn201Ser Single submitter ⚠
- p.Asn32Tyr Single submitter ⚠
- p.Asp188Asn Single submitter ⚠
- p.Asp194His Single submitter ⚠
- p.Asp261Asn Single submitter ⚠
- p.Asp75Gly Single submitter ⚠
- p.Glu259Ala Single submitter ⚠
- p.Lys213Arg Single submitter ⚠
- p.Lys283Arg Single submitter ⚠
- p.Lys293Asn Single submitter ⚠
- p.Phe288Val Single submitter ⚠
- p.Phe34Leu Single submitter ⚠
- p.Pro129Thr Single submitter ⚠
- p.Pro199Leu Single submitter ⚠
- p.Pro42Arg Single submitter ⚠
- p.Pro78Arg Single submitter ⚠
- p.Ser109Tyr Single submitter ⚠
- p.Ser229Arg Single submitter ⚠
- p.Ser318Asn Single submitter ⚠
- p.Thr285Ala Single submitter ⚠
- p.Thr290Ala Single submitter ⚠
- p.Thr69Met Single submitter ⚠
- p.Tyr33Ser Single submitter ⚠
- p.Val159Ala Single submitter ⚠
- p.Val216Met Single submitter ⚠
- p.Val217Ala Single submitter ⚠
- p.Val308Ala Single submitter ⚠