BABAM2 — 44 ClinVar variants
All ClinVar germline BABAM2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
1 Likely benign · 43 Uncertain significance
Full BABAM2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BABAM2 p.Arg133Gln Uncertain significance Single submitter
- BABAM2 p.Arg137Cys Uncertain significance Single submitter
- BABAM2 p.Asn109Asp Uncertain significance Single submitter
- BABAM2 p.Asn8Lys Uncertain significance Single submitter
- BABAM2 p.Asp290Glu Uncertain significance Single submitter
- BABAM2 p.Asp30Gly Uncertain significance Single submitter
- BABAM2 p.Gln266His Uncertain significance Single submitter
- BABAM2 p.Gly231Arg Uncertain significance Single submitter
- BABAM2 p.His227Gln Uncertain significance Single submitter
- BABAM2 p.Ile157Val Uncertain significance Single submitter
- BABAM2 p.Ile60Val Uncertain significance Single submitter
- BABAM2 p.Leu40Ser Uncertain significance Single submitter
- BABAM2 p.Lys162Arg Uncertain significance Single submitter
- BABAM2 p.Met139Leu Uncertain significance Single submitter
- BABAM2 p.Met13Val Uncertain significance Single submitter
- BABAM2 p.Pro107Leu Uncertain significance Single submitter
- BABAM2 p.Pro348Leu Uncertain significance Single submitter
- BABAM2 p.Ser206Thr Uncertain significance Single submitter
- BABAM2 p.Thr144Ala Uncertain significance Single submitter
- BABAM2 p.Thr186Ile Uncertain significance Single submitter
- BABAM2 p.Thr38Ile Uncertain significance Single submitter
- BABAM2 p.Tyr220Cys Uncertain significance Single submitter
- BABAM2 p.Tyr62Cys Uncertain significance Single submitter
- BABAM2 p.Val287Met Uncertain significance Single submitter
-
BABAM2 p.Asp209Gly
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 12
The independent predictors disagree with each other — read with care.
- BABAM2 p.Arg131Cys Uncertain significance Single submitter
- BABAM2 p.Arg172His Uncertain significance Single submitter
- BABAM2 p.Arg224Gln Uncertain significance Single submitter
- BABAM2 p.Asp95Val Uncertain significance Single submitter
- BABAM2 p.Gly50Arg Uncertain significance Single submitter
- BABAM2 p.Ile10Met Uncertain significance Single submitter
- BABAM2 p.Lys68Gln Uncertain significance Single submitter
- BABAM2 p.Pro241Ala Uncertain significance Single submitter
- BABAM2 p.Thr144Lys Uncertain significance Single submitter
- BABAM2 p.Val179Ile Uncertain significance Single submitter
- BABAM2 p.Val287Leu Uncertain significance Single submitter
- BABAM2 p.Val330Ile Uncertain significance Single submitter
All BABAM2 variants
Likely benign 1
- c.1088+11589A>C Single submitter
Uncertain significance 43
- c.1089-11028A>G Single submitter
- c.1089-11081G>A Single submitter
- c.1089-11108C>G Single submitter
- c.1089-11127G>A Single submitter
- c.1089-11144C>T Single submitter
- c.1089-11169C>G Single submitter
- p.Arg131Cys Single submitter ⚠
- p.Arg133Gln Single submitter ⚠
- p.Arg137Cys Single submitter ⚠
- p.Arg172His Single submitter ⚠
- p.Arg224Gln Single submitter ⚠
- p.Asn109Asp Single submitter ⚠
- p.Asn8Lys Single submitter ⚠
- p.Asp290Glu Single submitter ⚠
- p.Asp30Gly Single submitter ⚠
- p.Asp95Val Single submitter ⚠
- p.Gln266His Single submitter ⚠
- p.Gly231Arg Single submitter ⚠
- p.Gly50Arg Single submitter ⚠
- p.His227Gln Single submitter ⚠
- p.Ile10Met Single submitter ⚠
- p.Ile157Val Single submitter ⚠
- p.Ile60Val Single submitter ⚠
- p.Leu40Ser Single submitter ⚠
- p.Lys162Arg Single submitter ⚠
- p.Lys68Gln Single submitter ⚠
- p.Met139Leu Single submitter ⚠
- p.Met13Val Single submitter ⚠
- p.Pro107Leu Single submitter ⚠
- p.Pro241Ala Single submitter ⚠
- p.Pro348Leu Single submitter ⚠
- p.Ser206Thr Single submitter ⚠
- p.Thr144Ala Single submitter ⚠
- p.Thr144Lys Single submitter ⚠
- p.Thr186Ile Single submitter ⚠
- p.Thr38Ile Single submitter ⚠
- p.Tyr220Cys Single submitter ⚠
- p.Tyr62Cys Single submitter ⚠
- p.Val179Ile Single submitter ⚠
- p.Val287Leu Single submitter ⚠
- p.Val287Met Single submitter ⚠
- p.Val330Ile Single submitter ⚠
- p.Asp209Gly No assertion criteria prostate cancer ⚠