BAD — 27 ClinVar variants
All ClinVar germline BAD variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 26 flagged for review →
2 Likely benign · 25 Uncertain significance
Full BAD gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 26
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BAD p.Ala100Thr Uncertain significance Single submitter
- BAD p.Ala106Val Uncertain significance Single submitter
- BAD p.Ala138Thr Uncertain significance Single submitter
- BAD p.Ala41Thr Uncertain significance Single submitter
- BAD p.Arg116Ser Uncertain significance Single submitter
- BAD p.Arg161Gly Uncertain significance Single submitter
- BAD p.Gln152Arg Uncertain significance Single submitter
- BAD p.Glu81Gln Uncertain significance Single submitter
- BAD p.Gly33Ser Uncertain significance Single submitter
- BAD p.Gly65Arg Uncertain significance Single submitter
- BAD p.Gly79Val Uncertain significance Single submitter
- BAD p.His50Gln Uncertain significance Single submitter
- BAD p.Met86Ile Uncertain significance Single submitter
- BAD p.Ser134Thr Uncertain significance Single submitter
- BAD p.Ser32Ala Uncertain significance Single submitter
- BAD p.Trp147Cys Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- BAD p.Asp82Asn Uncertain significance Single submitter
- BAD p.Gly160Arg Uncertain significance Single submitter
- BAD p.Gly160Val Uncertain significance Single submitter
- BAD p.Gly33Asp Likely benign Single submitter
- BAD p.Leu104His Uncertain significance Single submitter
- BAD p.Phe121Ser Uncertain significance Single submitter
- BAD p.Pro130Ser Uncertain significance Single submitter
- BAD p.Ser144Asn Uncertain significance Single submitter
- BAD p.Ser25Asn Uncertain significance Single submitter
- BAD p.Ser49Asn Uncertain significance Single submitter
All BAD variants
Likely benign 2
- p.Asp82Glu Single submitter
- p.Gly33Asp Single submitter ⚠
Uncertain significance 25
- p.Ala100Thr Single submitter ⚠
- p.Ala106Val Single submitter ⚠
- p.Ala138Thr Single submitter ⚠
- p.Ala41Thr Single submitter ⚠
- p.Arg116Ser Single submitter ⚠
- p.Arg161Gly Single submitter ⚠
- p.Asp82Asn Single submitter ⚠
- p.Gln152Arg Single submitter ⚠
- p.Glu81Gln Single submitter ⚠
- p.Gly160Arg Single submitter ⚠
- p.Gly160Val Single submitter ⚠
- p.Gly33Ser Single submitter ⚠
- p.Gly65Arg Single submitter ⚠
- p.Gly79Val Single submitter ⚠
- p.His50Gln Single submitter ⚠
- p.Leu104His Single submitter ⚠
- p.Met86Ile Single submitter ⚠
- p.Phe121Ser Single submitter ⚠
- p.Pro130Ser Single submitter ⚠
- p.Ser134Thr Single submitter ⚠
- p.Ser144Asn Single submitter ⚠
- p.Ser25Asn Single submitter ⚠
- p.Ser32Ala Single submitter ⚠
- p.Ser49Asn Single submitter ⚠
- p.Trp147Cys Single submitter ⚠