BAG1 — 49 ClinVar variants
All ClinVar germline BAG1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
1 Benign · 3 Likely benign · 45 Uncertain significance
Full BAG1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BAG1 p.Ala280Thr Uncertain significance Single submitter
- BAG1 p.Ala317Val Uncertain significance Single submitter
- BAG1 p.Ala49Gly Uncertain significance Single submitter
- BAG1 p.Arg11Gly Uncertain significance Single submitter
- BAG1 p.Arg16Leu Uncertain significance Single submitter
- BAG1 p.Arg4Pro Uncertain significance Single submitter
- BAG1 p.Asn300Ser Uncertain significance Single submitter
- BAG1 p.Asn340Asp Uncertain significance Single submitter
- BAG1 p.Asp57Ala Uncertain significance Single submitter
- BAG1 p.Gln185Arg Uncertain significance Single submitter
- BAG1 p.Glu137Asp Uncertain significance Single submitter
- BAG1 p.Glu321Lys Uncertain significance Single submitter
- BAG1 p.Gly45Val Uncertain significance Single submitter
- BAG1 p.Leu204Phe Uncertain significance Single submitter
- BAG1 p.Leu271Pro Uncertain significance Single submitter
- BAG1 p.Lys238Asn Uncertain significance Single submitter
- BAG1 p.Pro59Leu Uncertain significance Single submitter
- BAG1 p.Pro70Arg Uncertain significance Single submitter
- BAG1 p.Ser131Gly Uncertain significance Single submitter
- BAG1 p.Ser54Gly Uncertain significance Single submitter
- BAG1 p.Thr294Ala Uncertain significance Single submitter
- BAG1 p.Val183Ile Uncertain significance Single submitter
- BAG1 p.Val228Ile Uncertain significance Single submitter
Predictors split 24
The independent predictors disagree with each other — read with care.
- BAG1 p.Ala110Thr Uncertain significance Single submitter
- BAG1 p.Ala270Val Uncertain significance Single submitter
- BAG1 p.Ala49Val Likely benign Single submitter
- BAG1 p.Ala64Thr Uncertain significance Single submitter
- BAG1 p.Ala65Val Uncertain significance Single submitter
- BAG1 p.Arg16Trp Uncertain significance Single submitter
- BAG1 p.Arg214Gln Uncertain significance Single submitter
- BAG1 p.Arg25Trp Uncertain significance Single submitter
- BAG1 p.Arg79Cys Uncertain significance Single submitter
- BAG1 p.Arg82Trp Uncertain significance Single submitter
- BAG1 p.Asp265Tyr Uncertain significance Single submitter
- BAG1 p.Glu179Gly Uncertain significance Single submitter
- BAG1 p.Glu34Lys Uncertain significance Single submitter
- BAG1 p.Gly219Glu Uncertain significance Single submitter
- BAG1 p.Gly5Val Uncertain significance Single submitter
- BAG1 p.Ile292Thr Uncertain significance Single submitter
- BAG1 p.Lys74Glu Uncertain significance Single submitter
- BAG1 p.Met200Val Uncertain significance Single submitter
- BAG1 p.Pro203Leu Uncertain significance Single submitter
- BAG1 p.Ser119Gly Uncertain significance Single submitter
- BAG1 p.Ser44Phe Uncertain significance Single submitter
- BAG1 p.Ser83Ile Uncertain significance Single submitter
- BAG1 p.Thr129Ala Likely benign Single submitter
- BAG1 p.Val146Leu Uncertain significance Single submitter
All BAG1 variants
Benign 1
- p.Ser304Gly Multiple submitters
Likely benign 3
- p.Ala49Val Single submitter ⚠
- p.Met116Val Single submitter
- p.Thr129Ala Single submitter ⚠
Uncertain significance 45
- p.Ala110Thr Single submitter ⚠
- p.Ala270Val Single submitter ⚠
- p.Ala280Thr Single submitter ⚠
- p.Ala317Val Single submitter ⚠
- p.Ala49Gly Single submitter ⚠
- p.Ala64Thr Single submitter ⚠
- p.Ala65Val Single submitter ⚠
- p.Arg11Gly Single submitter ⚠
- p.Arg16Leu Single submitter ⚠
- p.Arg16Trp Single submitter ⚠
- p.Arg214Gln Single submitter ⚠
- p.Arg25Trp Single submitter ⚠
- p.Arg4Pro Single submitter ⚠
- p.Arg79Cys Single submitter ⚠
- p.Arg82Trp Single submitter ⚠
- p.Asn300Ser Single submitter ⚠
- p.Asn340Asp Single submitter ⚠
- p.Asp265Tyr Single submitter ⚠
- p.Asp57Ala Single submitter ⚠
- p.Gln185Arg Single submitter ⚠
- p.Glu137Asp Single submitter ⚠
- p.Glu179Gly Single submitter ⚠
- p.Glu321Lys Single submitter ⚠
- p.Glu34Lys Single submitter ⚠
- p.Gly219Glu Single submitter ⚠
- p.Gly45Val Single submitter ⚠
- p.Gly5Val Single submitter ⚠
- p.Ile292Thr Single submitter ⚠
- p.Leu204Phe Single submitter ⚠
- p.Leu271Pro Single submitter ⚠
- p.Lys238Asn Single submitter ⚠
- p.Lys74Glu Single submitter ⚠
- p.Met200Val Single submitter ⚠
- p.Pro203Leu Single submitter ⚠
- p.Pro59Leu Single submitter ⚠
- p.Pro70Arg Single submitter ⚠
- p.Ser119Gly Single submitter ⚠
- p.Ser131Gly Single submitter ⚠
- p.Ser44Phe Single submitter ⚠
- p.Ser54Gly Single submitter ⚠
- p.Ser83Ile Single submitter ⚠
- p.Thr294Ala Single submitter ⚠
- p.Val146Leu Single submitter ⚠
- p.Val183Ile Single submitter ⚠
- p.Val228Ile Single submitter ⚠