BAG2 — 15 ClinVar variants
All ClinVar germline BAG2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 11 flagged for review →
2 Likely benign · 13 Uncertain significance
Full BAG2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 11
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BAG2 p.Ala131Val Uncertain significance Single submitter
- BAG2 p.Arg115Ser Uncertain significance Single submitter
- BAG2 p.Asn122Asp Uncertain significance Single submitter
- BAG2 p.Glu99Gln Uncertain significance Single submitter
- BAG2 p.Ile160Val Uncertain significance Single submitter
- BAG2 p.Ser184Ala Uncertain significance Single submitter
- BAG2 p.Ser31Ile Uncertain significance Single submitter
- BAG2 p.Val146Met Uncertain significance Single submitter
- BAG2 p.Val98Ile Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All BAG2 variants
Likely benign 2
- c.*4959T>C Single submitter
- p.His148Pro Single submitter
Uncertain significance 13
- c.*5020C>T Single submitter
- p.Ala131Val Single submitter ⚠
- p.Arg115Ser Single submitter ⚠
- p.Asn122Asp Single submitter ⚠
- p.Asp126Gly Single submitter ⚠
- p.Asp74= Single submitter
- p.Glu99Gln Single submitter ⚠
- p.Ile160Val Single submitter ⚠
- p.Ile181Thr Single submitter ⚠
- p.Ser184Ala Single submitter ⚠
- p.Ser31Ile Single submitter ⚠
- p.Val146Met Single submitter ⚠
- p.Val98Ile Single submitter ⚠